ID A0A942U768_9BACI Unreviewed; 378 AA.
AC A0A942U768;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 02-APR-2025, entry version 9.
DE SubName: Full=Conserved virulence factor C family protein {ECO:0000313|EMBL:MBS4215946.1};
GN ORFNames=KHA99_26335 {ECO:0000313|EMBL:MBS4215946.1};
OS Neobacillus rhizophilus.
OC Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Bacillaceae;
OC Neobacillus.
OX NCBI_TaxID=2833579 {ECO:0000313|EMBL:MBS4215946.1, ECO:0000313|Proteomes:UP000679749};
RN [1] {ECO:0000313|EMBL:MBS4215946.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FJAT-49825 {ECO:0000313|EMBL:MBS4215946.1};
RA Liu G.;
RT "Novel Bacillus species.";
RL Submitted (MAY-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-
CC lysine intermediate produced by deoxyhypusine synthase/DHPS on a
CC critical lysine of the eukaryotic translation initiation factor 5A/eIF-
CC 5A. This is the second step of the post-translational modification of
CC that lysine into an unusual amino acid residue named hypusine.
CC Hypusination is unique to mature eIF-5A factor and is essential for its
CC function. {ECO:0000256|ARBA:ARBA00045876}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MBS4215946.1}.
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DR EMBL; JAGYPF010000005; MBS4215946.1; -; Genomic_DNA.
DR RefSeq; WP_213120443.1; NZ_JAGYPF010000005.1.
DR Proteomes; UP000679749; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:TreeGrafter.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.30.1370.70; Scaffold protein Nfu/NifU, N-terminal domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR014824; Nfu/NifU_N.
DR InterPro; IPR036498; Nfu/NifU_N_sf.
DR InterPro; IPR004155; PBS_lyase_HEAT.
DR InterPro; IPR025989; Virulence_F_dom.
DR PANTHER; PTHR12697:SF37; CONSERVED VIRULENCE FACTOR C; 1.
DR PANTHER; PTHR12697; PBS LYASE HEAT-LIKE PROTEIN; 1.
DR Pfam; PF13646; HEAT_2; 1.
DR Pfam; PF08712; Nfu_N; 1.
DR Pfam; PF13769; Virulence_fact; 1.
DR SMART; SM00567; EZ_HEAT; 4.
DR SMART; SM00932; Nfu_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF110836; Hypothetical protein SAV1430; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000679749}.
FT DOMAIN 4..90
FT /note="Scaffold protein Nfu/NifU N-terminal"
FT /evidence="ECO:0000259|SMART:SM00932"
SQ SEQUENCE 378 AA; 43074 MW; 3A199E94516565CB CRC64;
MKIKSIEPTP SPNTMKILLD HELPMGKSHN YKKETALDAP PVIQAVLQID GIKGVYHVAD
FLAVERNAKY DWKELLPKVR HAFGEDTDQI ANTAKAINDH FGEIKVEVQM FKGIPLQVKL
TDGISEKRFG MPDYFLKARE NAQLPEDNYI LLRKWDNQGV RYGEMDQVGP EVVEELIAAY
PVQRLEELVQ KAQAAETQSE QKTKLKRRKV TADDMSNPDW RVRYQLLEQM DDPDLEDLPM
LEKALSDEKP SVRRLATVYL GMIKDQAVLP LLYRALKDKT VTVRRTAGDC LSDLGFPKAQ
DEMLEALKDP SKLIRWRAAM FLYEVGDEKA LSALKAAEND PEFEVSMQIK MAIERIEGGV
EAKGSVWKQM TEARKTEE
//
