ID A0A951UW70_9CYAN Unreviewed; 402 AA.
AC A0A951UW70;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 05-FEB-2025, entry version 10.
DE RecName: Full=Nucleoside permease {ECO:0000256|RuleBase:RU362018};
GN ORFNames=KME60_29775 {ECO:0000313|EMBL:MBW4671501.1};
OS Cyanomargarita calcarea GSE-NOS-MK-12-04C.
OC Bacteria; Bacillati; Cyanobacteriota; Cyanophyceae; Nostocales;
OC Cyanomargaritaceae; Cyanomargarita.
OX NCBI_TaxID=2839659 {ECO:0000313|EMBL:MBW4671501.1, ECO:0000313|Proteomes:UP000729701};
RN [1] {ECO:0000313|EMBL:MBW4671501.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GSE-NOS-MK-12-04C {ECO:0000313|EMBL:MBW4671501.1};
RA Pietrasiak N., Ward R., Stajich J.E., Kurbessoian T.;
RL Submitted (MAY-2021) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:MBW4671501.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GSE-NOS-MK-12-04C {ECO:0000313|EMBL:MBW4671501.1};
RX PubMed=34080906;
RA Ward R.D., Stajich J.E., Johansen J.R., Huntemann M., Clum A., Foster B.,
RA Foster B., Roux S., Palaniappan K., Varghese N., Mukherjee S.,
RA Reddy T.B.K., Daum C., Copeland A., Chen I.A., Ivanova N.N., Kyrpides N.C.,
RA Shapiro N., Eloe-Fadrosh E.A., Pietrasiak N.;
RT "Metagenome Sequencing to Explore Phylogenomics of Terrestrial
RT Cyanobacteria.";
RL Microbiol. Resour. Announc. 10:0-0(2022).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the concentrative nucleoside transporter (CNT)
CC (TC 2.A.41) family. {ECO:0000256|ARBA:ARBA00009033,
CC ECO:0000256|RuleBase:RU362018}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362018}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MBW4671501.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JAHHGZ010000046; MBW4671501.1; -; Genomic_DNA.
DR Proteomes; UP000729701; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005415; F:nucleoside:sodium symporter activity; IEA:TreeGrafter.
DR InterPro; IPR008276; C_nuclsd_transpt.
DR InterPro; IPR018270; C_nuclsd_transpt_met_bac.
DR InterPro; IPR011657; CNT_C_dom.
DR InterPro; IPR002668; CNT_N_dom.
DR InterPro; IPR011642; Gate_dom.
DR NCBIfam; TIGR00804; nupC; 1.
DR PANTHER; PTHR10590; SODIUM/NUCLEOSIDE COTRANSPORTER; 1.
DR PANTHER; PTHR10590:SF4; SOLUTE CARRIER FAMILY 28 MEMBER 3; 1.
DR Pfam; PF07670; Gate; 1.
DR Pfam; PF07662; Nucleos_tra2_C; 1.
DR Pfam; PF01773; Nucleos_tra2_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362018};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362018}; Transport {ECO:0000256|RuleBase:RU362018}.
FT TRANSMEM 29..47
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 86..108
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 163..185
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 254..277
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 344..369
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT DOMAIN 8..80
FT /note="Concentrative nucleoside transporter N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01773"
FT DOMAIN 88..185
FT /note="Nucleoside transporter/FeoB GTPase Gate"
FT /evidence="ECO:0000259|Pfam:PF07670"
FT DOMAIN 191..399
FT /note="Concentrative nucleoside transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07662"
SQ SEQUENCE 402 AA; 42881 MW; 0A999EE0132134E4 CRC64;
MERAISFLGI LVFIGISYGL SNNRRAIRWR TVVWGLGLEF AFALLILKAP GGLLLFKSLG
DVVSNFLSFS DEGAKFVFGS NFKDHLFAFQ VLPTIIFFSA FISVMYHYGI VQWVVNGLAW
VMMKTMKTSG AESLSTAGNI FLGPTESPLL VKPFVAMMTQ SELFTVMTGG FATVAGGVLG
AYLSFGLPPE HLIAAFFMTA PTALVVSKLL YPETEVSDTV GKVKMEMKSN YTNAIDAATT
GAIDGVQMAV NVGVMIIAFL GLLAAANALL GWLGAFVRLP QLSLEWVLSF VMAPVAWLMG
VPLADCGQVG ALLGKKTILN EFIAYADLGK LIQENKLSKR AVIIATYALC NFANIGSIGI
TIGGITGMAP NRQHDLARMG VKSMIGGLLA GFITACIAGI LI
//
