ID A0A953N7Z6_9BURK Unreviewed; 651 AA.
AC A0A953N7Z6;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 28-JAN-2026, entry version 14.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:MBZ1349272.1};
GN ORFNames=KZZ10_01310 {ECO:0000313|EMBL:MBZ1349272.1};
OS Zwartia hollandica.
OC Bacteria; Pseudomonadati; Pseudomonadota; Betaproteobacteria;
OC Burkholderiales; Alcaligenaceae; Zwartia.
OX NCBI_TaxID=324606 {ECO:0000313|EMBL:MBZ1349272.1, ECO:0000313|Proteomes:UP000739565};
RN [1] {ECO:0000313|EMBL:MBZ1349272.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=LF4-65 {ECO:0000313|EMBL:MBZ1349272.1};
RA Hahn M.W.;
RT "New genus and species of the family Alcaligenaceae.";
RL Submitted (JUL-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MBZ1349272.1}.
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DR EMBL; JAHXRI010000001; MBZ1349272.1; -; Genomic_DNA.
DR RefSeq; WP_259659682.1; NZ_JAHXRI010000001.1.
DR AlphaFoldDB; A0A953N7Z6; -.
DR Proteomes; UP000739565; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd15491; selB_III; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR048931; WHD_2nd_SelB_bact.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF21214; WHD_2nd_SelB_bact; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:MBZ1349272.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000739565}.
FT DOMAIN 1..170
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 651 AA; 70846 MW; F50C74D20C35F0EC CRC64;
MIIGTAGHID HGKTSLVEAL TGVNADRLPE EKARGITIDL GFAYAPTASG SVVGFVDVPG
HEKFVHTMAA GAIGMDHGLL VVAADDGLMP QTREHLRILD LLGVPQLSVA ITKIDLVDAQ
RVQAVTREVL DHVGLTRFGE VEAYPVSVRT QAGVAALQAA LFALRLSQPS EAPSYFRLAI
DRVFVVKGMG VAVTGAVIAG RIAVGDRVRL AHAGLEARVR SIHAQNQSAQ QATVGERCGI
VLSGVDVEQV TRGDWLVGPE LDLQTVRVDC LLSVPHDAER VIKDGELVLL HHGCQQVSAR
LILLDRGQIG AGQEAWAQIV LDRPLALCWQ DRLVLRDASA RHTLAGAQVM DIAPPVRGRK
KPERFDVLAT LQQADPVTAL LGLMDRARGP LDLTHWAAAM NRSAELLLRA LEPRLALQLQ
DGAHQLILGM EAQSGLTERV RACLDAFHIS DPDEPGLAFE RLRRMAVPDL QASVFKVWLT
AQISAGTFAL TGSFVHAVGH KVELSGPERI LWERALPKLL DGEFDPPWVR DVALMVSASE
EEVRLLFKKQ ARTSALTQLV KDLFYPDATM SRMADMIRET VGEQGFVSVI NFRDKLGIGR
KRAIQILEAF DRVGLTRRLV SLGRTGRAVE KDHRILRNAA LFRGAQQDVQ P
//
