ID A0A974BJJ3_SEDHY Unreviewed; 634 AA.
AC A0A974BJJ3;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 28-JAN-2026, entry version 15.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:NYB74036.1};
GN ORFNames=HZF24_07755 {ECO:0000313|EMBL:NYB74036.1};
OS Sedimentibacter hydroxybenzoicus DSM 7310.
OC Bacteria; Bacillati; Bacillota; Tissierellia; Sedimentibacter.
OX NCBI_TaxID=1123245 {ECO:0000313|EMBL:NYB74036.1, ECO:0000313|Proteomes:UP000611629};
RN [1] {ECO:0000313|EMBL:NYB74036.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DSM 7310 {ECO:0000313|EMBL:NYB74036.1};
RA Ma S.;
RT "Genomic analysis of a strain of Sedimentibacter Hydroxybenzoicus
RT DSM7310.";
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NYB74036.1}.
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DR EMBL; JACBNQ010000007; NYB74036.1; -; Genomic_DNA.
DR RefSeq; WP_179237731.1; NZ_JACBNQ010000007.1.
DR AlphaFoldDB; A0A974BJJ3; -.
DR Proteomes; UP000611629; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR PANTHER; PTHR43721:SF11; SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:NYB74036.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000611629}.
FT DOMAIN 1..173
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 634 AA; 72434 MW; 20DE21E41FE5C777 CRC64;
MKNIIIGTAG HIDHGKTTLI KALTGRETDR WEEEKRRGIT IDLGFTYFDL PNGNKAGIID
VPGHERFIKN MLAGVIGMDL VLLVVAADEG MMPQTTEHLN ILNMLGVKKG IVVITKYDLI
DSEWLELVKE DIKEELKDTF LENAPMIEVS SKTGYGLDKL IDAIVNKTET EIEERDINTI
PRLPIDRVFS ITGFGTVITG TLISGNLKKG DEVEIYPVNK ICKIRNIQVH SNDANEAYAG
QRTAINLSNV KKSEIYRGCV IAPKNSMKNT MMLDVKLSIL KSSRRIVENR SRLHLYTGTS
EILCRVVLLD RDELSPGESC YAQLRLEEEI AVRRKDKFIV RFYSPMETIG GGEIIEPVPL
KKKRFDDLLL EELKVKEKGS SSDVIEKIIT ENSKNVPSIS DIAKITALSE EEIRLSVEIL
EEEEKITVFN FKNEKYVWHK NYERSIEESI EKYLYKYHET KQYSKGTKKS EIKSRFLPAV
KQTVFDLIIQ SFESKGLIKT DGEYVSLGYF QIQYDEQYKN VEHNVIKILR EAKFELIKLE
ELAVMINSNK TEEIISLMLD DKKLVKIGES GITTSEIYND AKEKLVEFIK KNTKISAAQY
RDLLDTNRKI AIGLLEHFDS VKVTKRVEND RILF
//
