ID A0A976FJB0_BRELC Unreviewed; 1113 AA.
AC A0A976FJB0;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 08-OCT-2025, entry version 13.
DE RecName: Full=Protein FAN {ECO:0008006|Google:ProtNLM};
GN ORFNames=CCR75_001882 {ECO:0000313|EMBL:TDH67584.1};
OS Bremia lactucae (Lettuce downy mildew).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Bremia.
OX NCBI_TaxID=4779 {ECO:0000313|EMBL:TDH67584.1, ECO:0000313|Proteomes:UP000294530};
RN [1] {ECO:0000313|EMBL:TDH67584.1, ECO:0000313|Proteomes:UP000294530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SF5 {ECO:0000313|EMBL:TDH67584.1,
RC ECO:0000313|Proteomes:UP000294530};
RX PubMed=33883006; DOI=10.1186/s13059-021-02326-x;
RA Fletcher K., Zhang L., Gil J., Han R., Cavanaugh K., Michelmore R.;
RT "AFLAP: assembly-free linkage analysis pipeline using k-mers from genome
RT sequencing data.";
RL Genome Biol. 22:115-115(2021).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDH67584.1}.
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DR EMBL; SHOA02000014; TDH67584.1; -; Genomic_DNA.
DR RefSeq; XP_067817083.1; XM_067959983.1.
DR GeneID; 94345654; -.
DR OrthoDB; 26681at2759; -.
DR Proteomes; UP000294530; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR050865; BEACH_Domain.
DR InterPro; IPR057496; FAN-like_PH.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF123; PROTEIN FAN; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF25400; PH_FAN; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000294530};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 240..336
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 341..643
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 863..892
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1038..1079
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 1113 AA; 128513 MW; D9EDF27BA146CDDF CRC64;
MHGRRRSNKN IPTTRFSLLL LENGEFFLDV SILLIFFYSL KVRLLKLNSK DHNACRYLEP
NTLTHRKVPG RIKVCTRGLF FVPQDLQLPI LRFPFRCMTT EPMAECFQEF PENSKASSSK
PNDVALVYVM FQTKQVIEMR ERGMDLPYVV KDTVKRTDGY GSNTQSRSMY SFEGEVPAKY
MFTLQHVTYE AFLASIHILF EVSHLPRHLM IKIDEEALLA PVLVPRLTDK FDPSLLIDFR
ERLLMKTGCV VNRIEPLLKF PGCLMLTTQR LYFQPAPLNN VWDPVLNWEY TAIDQVYKRR
YLLQQIGLEI YLQSGDSFFF SFQSRNTRND LYALLVGQPE LQRCQRKDLL SMMRKWQRRE
LSNLEYLQFL NNASGRTRND LTQYPVFPWI LQDFTSLKLD LNDPSVYRDL SKPIGALNQE
RLDYFKARYE EMPCGDEAEG MPPPFLYGTH YSTPGYVLYF LVRKVPEYML CLQNGKFDAP
DRLFRSIKGT WEGCVSNPTD VKELIPEFYD CALSPTEWLN NTKHLDLGFT QSFERIDDVE
LPPWAHDNAE EFVTINRAAL ESDYVSEHLH DWIDLIFGYK QQGDEAINAN NCTFKKVFYY
LSYEGSVDLD TINDSVLKRS LESQIQEFGQ TPKLLFSTPH PSRNEKEGTI QIASPDLLLS
PRVLIPHIRK ISQTYAMMLE TQPYNRNHAT PSTFKDYAES DDDMELEKPT NDWESNSLNH
FECFQTCWNF DLLLPLKEVS RQLWFHKMSR KPFKQWKWRS RLPTMYDFSP SWSWKQRSTY
QLHQSEVTSA ILTHENSYLF TTSKDQSLKL SSVENVTQKR IVSSKFALSC CDVSFDERVV
FVGSWDNSVS MYSTSSGLVL DTIVAHSDGI SAIRVLPGRI LTSSWDSSIK LWRFTPFCIV
KTPLRAFFEC EESVLCLDVS RNGQYGAAGT RNGFVYLFNL QKLIFHNRRQ VNVLHNGGVS
SVVFAQDNRS YFCVNIQSEV SQFNLLGIKL WSMDIRTAGQ IRCFDSDGEY AVGGTTAGTI
LMWRLHEPAG MNTVYEIPQA HAASISALTI SSSGSILVSG AIDGSVNIWS LEKKQPLRRT
SRSIVSKDLY YSTRIVLFNP IVQLAEADCC LEF
//
