ID A0A979FKP0_HYAAZ Unreviewed; 562 AA.
AC A0A979FKP0;
DT 22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 1.
DT 18-JUN-2025, entry version 13.
DE SubName: Full=Protein enabled isoform X2 {ECO:0000313|RefSeq:XP_047737102.1};
GN Name=LOC108668193 {ECO:0000313|RefSeq:XP_047737102.1};
OS Hyalella azteca (Amphipod).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Peracarida; Amphipoda; Senticaudata;
OC Talitrida; Talitroidea; Hyalellidae; Hyalella.
OX NCBI_TaxID=294128 {ECO:0000313|Proteomes:UP000694843, ECO:0000313|RefSeq:XP_047737102.1};
RN [1] {ECO:0000313|RefSeq:XP_047737102.1}
RP IDENTIFICATION.
RC TISSUE=Whole organism {ECO:0000313|RefSeq:XP_047737102.1};
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the Ena/VASP family.
CC {ECO:0000256|ARBA:ARBA00009785}.
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DR RefSeq; XP_047737102.1; XM_047881146.1.
DR GeneID; 108668193; -.
DR Proteomes; UP000694843; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR CDD; cd01207; EVH1_Ena_VASP-like; 1.
DR FunFam; 2.30.29.30:FF:000047; vasodilator-stimulated phosphoprotein isoform X2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR038023; VASP_sf.
DR InterPro; IPR014885; VASP_tetra.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR PANTHER; PTHR11202:SF22; PROTEIN ENABLED; 1.
DR PANTHER; PTHR11202; SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF08776; VASP_tetra; 1.
DR Pfam; PF00568; WH1; 1.
DR SMART; SM00461; WH1; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF118370; Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain; 1.
DR PROSITE; PS50229; WH1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000694843};
KW SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT DOMAIN 16..129
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT REGION 131..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..153
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..176
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..252
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..275
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..359
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..382
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..401
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..487
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 562 AA; 59728 MW; E8F8A2B229184463 CRC64;
MNRFQNSESS IEDAGELRNG EVSICQARAS VMLYDDGTKK WVPAGSSSGL SKVQIYHHTG
NTSFRVVGRK INDHEVVINC AIQKALKYNQ ATPTFHQWRD NRQVYGLNFS SKDDADAFAQ
AMLTQALEIL NNGPGAGRQM PPPPPPHQTP PGMPSQQQMH PPQPPPHQQS NPPLPPHQLQ
QYQSQPPPQP IYQQQPLPQV YDEDLAYRYG TSHSTSAPEH IYGGTPQQQQ YQQPQYQPAQ
YADQQPQYSD QQQVDRTYDN FSHYQDTRSL TRDESLMLSG GLRMAPQAPP PPPSSHHRNN
SAPTGPGVVP PAPPPAPPAP PAPPHAPPAP VLSSPAPAPP PPPPPPMGGG PPPPPPPPSH
HLAAAQDDGA GGTSLSAALA TAKLRKMRPP DSDSTSSSSS GGSSGGSIGK GPADRPPLMG
MSMMDEMAAT LARRKAKTQA NGNAAENTSG GGGGTLKGLG QKSPSSSKLS TNGITSNNNT
SSRSSTTSGG GGESPKPARK RFGSTCDDGG PTRLNGVSGN EGCVTSQDLD NLREDLMAHI
TKEVNKCKLE IIEAIKMELN RR
//
