ID A0A9D3MEA4_ANGAN Unreviewed; 746 AA.
AC A0A9D3MEA4;
DT 03-MAY-2023, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2023, sequence version 1.
DT 18-JUN-2025, entry version 11.
DE RecName: Full=CKK domain-containing protein {ECO:0000259|PROSITE:PS51508};
GN ORFNames=ANANG_G00125760 {ECO:0000313|EMBL:KAG5847411.1};
OS Anguilla anguilla (European freshwater eel) (Muraena anguilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Anguillidae;
OC Anguilla.
OX NCBI_TaxID=7936 {ECO:0000313|EMBL:KAG5847411.1, ECO:0000313|Proteomes:UP001044222};
RN [1] {ECO:0000313|EMBL:KAG5847411.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tag_6206 {ECO:0000313|EMBL:KAG5847411.1};
RC TISSUE=Liver {ECO:0000313|EMBL:KAG5847411.1};
RA Henkel C., Jong-Raadsen S.A., Dufour S., Weltzien F.-A., Palstra A.P.,
RA Pelster B., Spaink H.P., Van Den Thillart G.E., Jansen H., Zahm M.,
RA Klopp C., Cedric C., Louis A., Berthelot C., Parey E., Roest Crollius H.,
RA Montfort J., Robinson-Rechavi M., Bucao C., Bouchez O., Gislard M.,
RA Lluch J., Milhes M., Lampietro C., Lopez Roques C., Donnadieu C.,
RA Braasch I., Desvignes T., Postlethwait J., Bobe J., Guiguen Y., Dirks R.;
RT "A chromosome-scale assembly of European eel, Anguilla anguilla.";
RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- DOMAIN: The CKK domain binds microtubules. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
CC -!- SIMILARITY: Belongs to the CAMSAP1 family. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG5847411.1}.
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DR EMBL; JAFIRN010000006; KAG5847411.1; -; Genomic_DNA.
DR Proteomes; UP001044222; Chromosome 6.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0036449; C:microtubule minus-end; IEA:TreeGrafter.
DR GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR GO; GO:0051011; F:microtubule minus-end binding; IEA:TreeGrafter.
DR GO; GO:0030507; F:spectrin binding; IEA:InterPro.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:TreeGrafter.
DR GO; GO:0007026; P:negative regulation of microtubule depolymerization; IEA:TreeGrafter.
DR GO; GO:0031175; P:neuron projection development; IEA:InterPro.
DR FunFam; 3.10.20.360:FF:000001; Calmodulin-regulated spectrin-associated protein 3 isoform 2; 1.
DR Gene3D; 3.10.20.360; CKK domain; 1.
DR InterPro; IPR032940; CAMSAP.
DR InterPro; IPR031372; CAMSAP_CC1.
DR InterPro; IPR038209; CKK_dom_sf.
DR InterPro; IPR014797; CKK_domain.
DR InterPro; IPR011033; PRC_barrel-like_sf.
DR PANTHER; PTHR21595:SF1; CALMODULIN-REGULATED SPECTRIN-ASSOCIATED PROTEIN 2; 1.
DR PANTHER; PTHR21595; PATRONIN; 1.
DR Pfam; PF17095; CAMSAP_CC1; 1.
DR Pfam; PF08683; CAMSAP_CKK; 1.
DR SMART; SM01051; CAMSAP_CKK; 1.
DR SUPFAM; SSF50346; PRC-barrel domain; 1.
DR PROSITE; PS51508; CKK; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|PROSITE-
KW ProRule:PRU00841}; Reference proteome {ECO:0000313|Proteomes:UP001044222}.
FT DOMAIN 606..740
FT /note="CKK"
FT /evidence="ECO:0000259|PROSITE:PS51508"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 86..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 585..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 50..77
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 133..160
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 406..464
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 90..102
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..200
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..269
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 746 AA; 82819 MW; 8FDCFDF519EAC753 CRC64;
MTSFAEQKFR KLNHHHHQLG EGRSSGSGYV KTTPESSEPG VPHSVAWAPM LQLKMKLEEK
RRAIEAQKKK VEAAFTRHRQ RMGRTAFLNV GGGGGRGGGG ERPPGKAPDG AEQGHGGWSR
SPGEEGGGGG ADLAEYTRSI ERLNTSLSFL QTEMQRLAQQ QEVIMQMREH QSWAASPPAG
PAPSPQRQRK SASFHSRTPR TPRPSELKIS PFSRMLNTPQ SVDSLPRLRR FSPSQTQLSS
FAYFGHDEPP SPSSSPAPTH TPPPDPAPSP RSKTAAPGNL NQSGPTTGCL RDRLLHTGGR
RRWRGTHVRR AQMNLKLPVS EVLTQPVAQV VRVTPVKHDH TLNTSSRNLI EVPLSVVKAP
EAQAVGNSGS SSGEAEPVSE LLSGDQKICC GFFFKDDLKG EEDIALKRAA LLEKRLRRER
EAQQKKLELE AELEQKKELA RLKAEEEREK KEDEKARREY IKQEYLRRKQ LKLMDDMDAV
IKPRPSSTKQ KKPRPKSMHR DSVESPRIPP RAGSRPRVFS VSSLSLASLN LGDNDSVNSD
RRTPRSSKLA SGNLYYFLNS PKVKKTRPDS ADGFLSPCLL GSGNGEKDWE NGSTTSSVAS
NTEYTGPKLY KEPSAKSNKH IIQNALAHCC LAGKVNEGQK NRILEEIDKS EANNFLILFR
DSGCQFRSLY MYYPESEEIT KLAGIGPKSI TRKMIENLYK YNSDRKQFSH IPAKTMSASV
DAITIYGHLW QIKKSATPKK ALTLKS
//
