ID   A0A9D3MEY0_ANGAN        Unreviewed;       716 AA.
AC   A0A9D3MEY0;
DT   03-MAY-2023, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2023, sequence version 1.
DT   18-JUN-2025, entry version 11.
DE   RecName: Full=E3 UFM1-protein ligase 1 {ECO:0000256|ARBA:ARBA00019780};
DE   AltName: Full=E3 UFM1-protein transferase 1 {ECO:0000256|ARBA:ARBA00031516};
GN   ORFNames=ANANG_G00118020 {ECO:0000313|EMBL:KAG5846727.1};
OS   Anguilla anguilla (European freshwater eel) (Muraena anguilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Anguillidae;
OC   Anguilla.
OX   NCBI_TaxID=7936 {ECO:0000313|EMBL:KAG5846727.1, ECO:0000313|Proteomes:UP001044222};
RN   [1] {ECO:0000313|EMBL:KAG5846727.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tag_6206 {ECO:0000313|EMBL:KAG5846727.1};
RC   TISSUE=Liver {ECO:0000313|EMBL:KAG5846727.1};
RA   Henkel C., Jong-Raadsen S.A., Dufour S., Weltzien F.-A., Palstra A.P.,
RA   Pelster B., Spaink H.P., Van Den Thillart G.E., Jansen H., Zahm M.,
RA   Klopp C., Cedric C., Louis A., Berthelot C., Parey E., Roest Crollius H.,
RA   Montfort J., Robinson-Rechavi M., Bucao C., Bouchez O., Gislard M.,
RA   Lluch J., Milhes M., Lampietro C., Lopez Roques C., Donnadieu C.,
RA   Braasch I., Desvignes T., Postlethwait J., Bobe J., Guiguen Y., Dirks R.;
RT   "A chromosome-scale assembly of European eel, Anguilla anguilla.";
RL   Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the UFL1 family.
CC       {ECO:0000256|ARBA:ARBA00010789}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAG5846727.1}.
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DR   EMBL; JAFIRN010000006; KAG5846727.1; -; Genomic_DNA.
DR   Proteomes; UP001044222; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:TreeGrafter.
DR   GO; GO:0061666; F:UFM1 ligase activity; IEA:InterPro.
DR   GO; GO:1990592; P:protein K69-linked ufmylation; IEA:TreeGrafter.
DR   GO; GO:0032434; P:regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:TreeGrafter.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:TreeGrafter.
DR   InterPro; IPR018611; Ufl1.
DR   InterPro; IPR056761; Ufl1-like_C.
DR   InterPro; IPR056580; Ufl1_dom.
DR   InterPro; IPR056579; Ufl1_N.
DR   PANTHER; PTHR31057; E3 UFM1-PROTEIN LIGASE 1; 1.
DR   PANTHER; PTHR31057:SF0; E3 UFM1-PROTEIN LIGASE 1; 1.
DR   Pfam; PF09743; E3_UFM1_ligase; 1.
DR   Pfam; PF23659; UFL1; 1.
DR   Pfam; PF25041; UFL1_C; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP001044222};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          7..284
FT                   /note="E3 UFM1-protein ligase 1-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF09743"
FT   DOMAIN          542..659
FT                   /note="E3 UFM1-protein ligase 1-like"
FT                   /evidence="ECO:0000259|Pfam:PF23659"
FT   DOMAIN          665..710
FT                   /note="E3 UFM1-protein ligase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF25041"
FT   REGION          405..480
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        414..423
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        446..455
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   716 AA;  79898 MW;  D3C64684EB3B3468 CRC64;
     MAADWEEIRR LAADFQRAQF ADTVQRLSER NCIEIVAKLV GDKQLDVVHT LDGKEYITPT
     QISREIRDEL YVHGGRVNIV DLQQIINVDW VHVEARANDI AKSDKSVQLV LGQLIDDTYL
     DQLAEEVNDK LQAAGQVSIA ELCKSFDLPG DFLTEVLSQR LGKIINGQMD QYNRGVIFTQ
     AFLSRHKARV CGLFSAVTRP TPLINLIGLH GFHEHLLYSV LEELVNSGRL KGTVVGGRQD
     KAVYIPDIYS KTQNAWVDSF LKQNGYLEFD ALTRLGIPDP VNYIKKRFKT SKLLFLKAVC
     VGPAIVDQVE ASVEEAVNSG SWTDLQPMLP SCLSPEDISI LLNQVMRTAN VQSSARIVSG
     TVVVSEKFIG SCLSLFDESM QQRAVKEIKN NPVFLFTEED VKQGSALAEN AAPSKKEKRE
     EQRRKKATEG SGSVKGGGGG NAREIRIRKT KKKSRRGEED SDEENAAAPQ SRNKQAEVPF
     LSPEEVTAVL EKHVCDCPEE MLSELAEHLM RPLTKKYQEV VRTVFMSSTN SSTGASRKQN
     VKDLQEEINN LYHNIRLFEK GTKLFSDETQ ASISKHVLKT VCADVTNILV NFAAAELMTA
     AESPSSITNE VRVKILGKLP EETKAPLMKL HNSLNGKSIE DFLTNLEPSA EVCGFLLKKG
     DKKRERQALF QHRQALLEQL KVTEDPALVL HLASVLLFQL HTHCMLHARG DACRRS
//