ID A0A9D3MG75_ANGAN Unreviewed; 245 AA.
AC A0A9D3MG75;
DT 03-MAY-2023, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2023, sequence version 1.
DT 18-JUN-2025, entry version 12.
DE RecName: Full=Homeobox domain-containing protein {ECO:0000259|PROSITE:PS50071};
GN ORFNames=ANANG_G00120540 {ECO:0000313|EMBL:KAG5846963.1};
OS Anguilla anguilla (European freshwater eel) (Muraena anguilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Anguillidae;
OC Anguilla.
OX NCBI_TaxID=7936 {ECO:0000313|EMBL:KAG5846963.1, ECO:0000313|Proteomes:UP001044222};
RN [1] {ECO:0000313|EMBL:KAG5846963.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tag_6206 {ECO:0000313|EMBL:KAG5846963.1};
RC TISSUE=Liver {ECO:0000313|EMBL:KAG5846963.1};
RA Henkel C., Jong-Raadsen S.A., Dufour S., Weltzien F.-A., Palstra A.P.,
RA Pelster B., Spaink H.P., Van Den Thillart G.E., Jansen H., Zahm M.,
RA Klopp C., Cedric C., Louis A., Berthelot C., Parey E., Roest Crollius H.,
RA Montfort J., Robinson-Rechavi M., Bucao C., Bouchez O., Gislard M.,
RA Lluch J., Milhes M., Lampietro C., Lopez Roques C., Donnadieu C.,
RA Braasch I., Desvignes T., Postlethwait J., Bobe J., Guiguen Y., Dirks R.;
RT "A chromosome-scale assembly of European eel, Anguilla anguilla.";
RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the SIX/Sine oculis homeobox family.
CC {ECO:0000256|ARBA:ARBA00008161}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG5846963.1}.
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DR EMBL; JAFIRN010000006; KAG5846963.1; -; Genomic_DNA.
DR OMA; PAGICCV; -.
DR OrthoDB; 3501850at2759; -.
DR Proteomes; UP001044222; Chromosome 6.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:TreeGrafter.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR GO; GO:0001654; P:eye development; IEA:TreeGrafter.
DR CDD; cd00086; homeodomain; 1.
DR FunFam; 1.10.10.60:FF:000046; SIX homeobox 3; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR001356; HD.
DR InterPro; IPR009057; Homeodomain-like_sf.
DR InterPro; IPR031701; SIX1_SD.
DR PANTHER; PTHR10390; HOMEOBOX PROTEIN SIX; 1.
DR PANTHER; PTHR10390:SF74; HOMEOBOX PROTEIN SIX6; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF16878; SIX1_SD; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP001044222}.
FT DOMAIN 126..186
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 128..187
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 191..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 245 AA; 27916 MW; D17DBA4A80C308E1 CRC64;
MFQLPILNFS PQQVAGVCET LEESGDVERL GRFLWSLPVA PAACDVLNKN ESVLRARAIV
AFHTGNFREL YHILESHKFT KESHSKLQAL WLESHYQEAE KLRGRPLGPV DKYRVRKKFP
LPRTIWDGEQ KTHCFKERIR HLLREWYLQD PYPNPSKKRE LAQATGLTPT QVGNWFKNRR
QRDRAAAAKN RLQQQVLSHG SVRSIAEDDG TLDRLGTASS PETSLTRKAA PSAVSLTSSD
SECDI
//
