ID   A0A9D3MRQ7_ANGAN        Unreviewed;       345 AA.
AC   A0A9D3MRQ7;
DT   03-MAY-2023, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2023, sequence version 1.
DT   28-JAN-2026, entry version 11.
DE   RecName: Full=Bardet-Biedl syndrome 5 protein homolog {ECO:0000256|PIRNR:PIRNR010072};
GN   ORFNames=ANANG_G00064820 {ECO:0000313|EMBL:KAG5852652.1};
OS   Anguilla anguilla (European freshwater eel) (Muraena anguilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Anguillidae;
OC   Anguilla.
OX   NCBI_TaxID=7936 {ECO:0000313|EMBL:KAG5852652.1, ECO:0000313|Proteomes:UP001044222};
RN   [1] {ECO:0000313|EMBL:KAG5852652.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tag_6206 {ECO:0000313|EMBL:KAG5852652.1};
RC   TISSUE=Liver {ECO:0000313|EMBL:KAG5852652.1};
RA   Henkel C., Jong-Raadsen S.A., Dufour S., Weltzien F.-A., Palstra A.P.,
RA   Pelster B., Spaink H.P., Van Den Thillart G.E., Jansen H., Zahm M.,
RA   Klopp C., Cedric C., Louis A., Berthelot C., Parey E., Roest Crollius H.,
RA   Montfort J., Robinson-Rechavi M., Bucao C., Bouchez O., Gislard M.,
RA   Lluch J., Milhes M., Lampietro C., Lopez Roques C., Donnadieu C.,
RA   Braasch I., Desvignes T., Postlethwait J., Bobe J., Guiguen Y., Dirks R.;
RT   "A chromosome-scale assembly of European eel, Anguilla anguilla.";
RL   Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for ciliogenesis. {ECO:0000256|PIRNR:PIRNR010072}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC       {ECO:0000256|ARBA:ARBA00004309, ECO:0000256|PIRNR:PIRNR010072}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,
CC       centriolar satellite {ECO:0000256|ARBA:ARBA00004607}.
CC   -!- SIMILARITY: Belongs to the BBS5 family. {ECO:0000256|ARBA:ARBA00005822,
CC       ECO:0000256|PIRNR:PIRNR010072}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAG5852652.1}.
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DR   EMBL; JAFIRN010000003; KAG5852652.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A9D3MRQ7; -.
DR   OMA; PNFGIQY; -.
DR   OrthoDB; 10261999at2759; -.
DR   Proteomes; UP001044222; Unassembled WGS sequence.
DR   GO; GO:0034464; C:BBSome; IEA:UniProtKB-UniRule.
DR   GO; GO:0034451; C:centriolar satellite; IEA:UniProtKB-SubCell.
DR   GO; GO:0036064; C:ciliary basal body; IEA:TreeGrafter.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:TreeGrafter.
DR   GO; GO:0060271; P:cilium assembly; IEA:TreeGrafter.
DR   FunFam; 2.30.29.30:FF:000232; Bardet-Biedl syndrome 5 isoform 1; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR006606; BBL5.
DR   InterPro; IPR030804; BBS5/fem-3.
DR   InterPro; IPR014003; BBS5_PH.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR21351:SF0; BARDET-BIEDL SYNDROME 5 PROTEIN; 1.
DR   PANTHER; PTHR21351; BARDET-BIEDL SYNDROME PROTEIN 5; 1.
DR   Pfam; PF07289; BBL5; 1.
DR   PIRSF; PIRSF010072; DUF1448; 1.
DR   SMART; SM00683; DM16; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|PIRNR:PIRNR010072};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273,
KW   ECO:0000256|PIRNR:PIRNR010072};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|PIRNR:PIRNR010072};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR010072};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW   ECO:0000256|PIRNR:PIRNR010072};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR010072};
KW   Reference proteome {ECO:0000313|Proteomes:UP001044222}.
FT   DOMAIN          31..85
FT                   /note="BBSome complex member BBS5 PH"
FT                   /evidence="ECO:0000259|SMART:SM00683"
FT   DOMAIN          161..215
FT                   /note="BBSome complex member BBS5 PH"
FT                   /evidence="ECO:0000259|SMART:SM00683"
SQ   SEQUENCE   345 AA;  39368 MW;  033FB0407C3E726E CRC64;
     MTMASVLDAL WEDRDVRFDI TPQQMKMRPG EVLIDCLDSI EDTKGNNGDR GRLLVTNLRI
     IWHSMALPRV NLSVGYNSII NITTRTANSK LRGQTEALYI LTKCLNTRFE FIFTNVVPGS
     PRLFTSVIAV HRAYETSKMY RDLKLRGALI QNKQLRLLPQ EQVYDKINGV WNLSSDQGNL
     GTFFITNVRI VWHANMNESF NVSIPYLQIR SIRIRDSKFG LALVIESSQQ TGGYVLGFKI
     DPMEKLQDAV KEINSLHKVY SASPIFGVDY EMEEKPQPLE ELTVEQLPDD MEIEPDEQTD
     AFTAYFADGN KQQDREPVFS EELGIAIEKL KDGFNLQGLW EVMGC
//