ID A0A9D3PG24_MEGAT Unreviewed; 726 AA.
AC A0A9D3PG24;
DT 03-MAY-2023, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2023, sequence version 1.
DT 05-FEB-2025, entry version 9.
DE RecName: Full=Phosphatidylinositol 3-kinase regulatory subunit beta {ECO:0008006|Google:ProtNLM};
GN ORFNames=MATL_G00237280 {ECO:0000313|EMBL:KAG7456578.1};
OS Megalops atlanticus (Tarpon) (Clupea gigantea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Elopiformes; Megalopidae; Megalops.
OX NCBI_TaxID=7932 {ECO:0000313|EMBL:KAG7456578.1, ECO:0000313|Proteomes:UP001046870};
RN [1] {ECO:0000313|EMBL:KAG7456578.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=YG-15Mar2019-1 {ECO:0000313|EMBL:KAG7456578.1};
RC TISSUE=Brain {ECO:0000313|EMBL:KAG7456578.1};
RA Zahm M., Roques C., Cabau C., Klopp C., Donnadieu C., Jouanno E.,
RA Lampietro C., Louis A., Herpin A., Echchiki A., Berthelot C., Parey E.,
RA Roest-Crollius H., Braasch I., Postlethwait J., Bobe J., Montfort J.,
RA Bouchez O., Begum T., Mejri S., Adams A., Chen W.-J., Guiguen Y.;
RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PI3K p85 subunit family.
CC {ECO:0000256|ARBA:ARBA00009442}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG7456578.1}.
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DR EMBL; JAFDVH010000022; KAG7456578.1; -; Genomic_DNA.
DR OrthoDB; 3175255at2759; -.
DR Proteomes; UP001046870; Chromosome 22.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:TreeGrafter.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR CDD; cd12926; iSH2_PIK3R2; 1.
DR CDD; cd09930; SH2_cSH2_p85_like; 1.
DR CDD; cd09942; SH2_nSH2_p85_like; 1.
DR CDD; cd11909; SH3_PI3K_p85beta; 1.
DR FunFam; 2.30.30.40:FF:000075; phosphatidylinositol 3-kinase regulatory subunit alpha; 1.
DR FunFam; 3.30.505.10:FF:000006; Phosphatidylinositol 3-kinase regulatory subunit alpha; 1.
DR FunFam; 3.30.505.10:FF:000014; Phosphatidylinositol 3-kinase regulatory subunit alpha; 1.
DR FunFam; 1.10.287.1490:FF:000001; Putative phosphatidylinositol 3-kinase regulatory subunit alpha; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR032498; PI3K_P85_iSH2.
DR InterPro; IPR035586; PI3K_p85beta_SH3.
DR InterPro; IPR035020; PI3kinase_P85_cSH2.
DR InterPro; IPR035022; PI3kinase_P85_nSH2.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF1; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA; 1.
DR Pfam; PF16454; PI3K_P85_iSH2; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00017; SH2; 2.
DR PRINTS; PR00678; PI3KINASEP85.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00252; SH2; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50001; SH2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP001046870};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 3..79
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 113..297
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 331..426
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 625..720
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 147..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 533..560
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 152..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 726 AA; 82212 MW; F67582D348710D97 CRC64;
MAAEGFQYRA LYAYSKDWEE DIDLQPGDAL MVTKASLLAL GVPEGDEQHP ERVGWITGVN
ERTKQRGDFP GTYVQYVGPV MMSPPSNQPR LQRPLPAVPR PAPPPAQQAI SVLDLTEQFA
PPECAPPVLV KLVEAIEKQG LDCETLYRTG AERQTPNSET ESLGAEKGSC DIQTLSEAVI
GYLQDLPSPV IPASVHQELQ AAVQQGADES VADCGSRLRC ALESPAVPPQ NLHTLQYLLK
HLAQVCQHSD RNGLDPRTLG RTFGPLLLRA SVSGAEAEPE LPALVVERLL LERVWEQEQT
PPALPPKPPK SKAVTPPVTN GNSGGLSEAE WYWGDISREE VNEKMRDTAD GTFLVRDASS
KVQGEYTLTL RKGGNNKLIK IFHRGGCYGF SEPLTFPSVV DLISHYRHES LAQYNAKLDT
RLLYPISRFQ QDQVVKEDSV EAVGEQLKVY HEQYQEKSRE YDTLYEEYTR SSQELQMKRT
AIEAFNETIK IFEEQCETQE RYSKEYIEKF RREGNDKEIQ RIQSNSEKLK SRVTEIHDSK
RKLEQDLQQQ AAENREIDKR MNSLKPDLMQ LRKIREQYLV WLTQKGTRQR KINKWLGINN
EAEDLYSLMD DEEEEDLPHH NELTWYVGNI KRAQAEELLR GKCDGTFLIR DSQTQKGSFA
CSVVVDGDVK HCVIYKTATG YGFAEPYNLY GSLKELVLHY RHASLVQHND SLNVTLASPV
LSQHHR
//
