ID A0A9D3RV77_ANGAN Unreviewed; 772 AA.
AC A0A9D3RV77;
DT 03-MAY-2023, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2023, sequence version 1.
DT 18-JUN-2025, entry version 12.
DE RecName: Full=Anaphase-promoting complex subunit 5 {ECO:0000256|ARBA:ARBA00016066};
DE AltName: Full=Cyclosome subunit 5 {ECO:0000256|ARBA:ARBA00031069};
GN ORFNames=ANANG_G00191350 {ECO:0000313|EMBL:KAG5840687.1};
OS Anguilla anguilla (European freshwater eel) (Muraena anguilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Anguillidae;
OC Anguilla.
OX NCBI_TaxID=7936 {ECO:0000313|EMBL:KAG5840687.1, ECO:0000313|Proteomes:UP001044222};
RN [1] {ECO:0000313|EMBL:KAG5840687.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tag_6206 {ECO:0000313|EMBL:KAG5840687.1};
RC TISSUE=Liver {ECO:0000313|EMBL:KAG5840687.1};
RA Henkel C., Jong-Raadsen S.A., Dufour S., Weltzien F.-A., Palstra A.P.,
RA Pelster B., Spaink H.P., Van Den Thillart G.E., Jansen H., Zahm M.,
RA Klopp C., Cedric C., Louis A., Berthelot C., Parey E., Roest Crollius H.,
RA Montfort J., Robinson-Rechavi M., Bucao C., Bouchez O., Gislard M.,
RA Lluch J., Milhes M., Lampietro C., Lopez Roques C., Donnadieu C.,
RA Braasch I., Desvignes T., Postlethwait J., Bobe J., Guiguen Y., Dirks R.;
RT "A chromosome-scale assembly of European eel, Anguilla anguilla.";
RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC progression through mitosis and the G1 phase of the cell cycle. The
CC APC/C complex acts by mediating ubiquitination and subsequent
CC degradation of target proteins: it mainly mediates the formation of
CC 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the
CC formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The
CC APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked
CC branched ubiquitin chains on target proteins.
CC {ECO:0000256|ARBA:ARBA00045696}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the APC5 family.
CC {ECO:0000256|ARBA:ARBA00007450}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG5840687.1}.
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DR EMBL; JAFIRN010000010; KAG5840687.1; -; Genomic_DNA.
DR OMA; DANMGMA; -.
DR OrthoDB; 2504561at2759; -.
DR Proteomes; UP001044222; Chromosome 10.
DR GO; GO:0005680; C:anaphase-promoting complex; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IEA:TreeGrafter.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0045842; P:positive regulation of mitotic metaphase/anaphase transition; IEA:TreeGrafter.
DR GO; GO:0070979; P:protein K11-linked ubiquitination; IEA:TreeGrafter.
DR CDD; cd16270; Apc5_N; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR037679; Apc5.
DR InterPro; IPR026000; Apc5_dom.
DR InterPro; IPR048968; Apc5_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12830; ANAPHASE-PROMOTING COMPLEX SUBUNIT 5; 1.
DR PANTHER; PTHR12830:SF9; ANAPHASE-PROMOTING COMPLEX SUBUNIT 5; 1.
DR Pfam; PF12862; ANAPC5; 3.
DR Pfam; PF21371; Apc5_N; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP001044222};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 30..161
FT /note="Anaphase-promoting complex subunit 5 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21371"
FT DOMAIN 270..369
FT /note="Anaphase-promoting complex subunit 5"
FT /evidence="ECO:0000259|Pfam:PF12862"
FT DOMAIN 475..511
FT /note="Anaphase-promoting complex subunit 5"
FT /evidence="ECO:0000259|Pfam:PF12862"
FT DOMAIN 608..665
FT /note="Anaphase-promoting complex subunit 5"
FT /evidence="ECO:0000259|Pfam:PF12862"
SQ SEQUENCE 772 AA; 86728 MW; AB4BD3CBB86765BB CRC64;
MASVHESLYF NPMMTNGVVH ANVFGIKDWV TPYKISVLVL LDEMTMSKRM RLLERRRLNE
LILPLQQGPD LTLGQLLRTI DECCPKTAYA VKIRLHVMAG GELKDMESFF ATLPSPFSDL
DSEAYKTSVV GLFMRHMLLA YNKLSFSQVY KLYTALQRYY HGHYVPGLDS KANLSATATE
DTDMELTNTE DTMEGKMEKE ELDSEPLRDS ELLNVDTPSR GPLSQKQAEY FLARQAYLLK
NDENKALKPA ALQEELNNML KFNPDFAEAH YLSYLNSMRV QDIFISTHSL LHYFDRLILT
GAEGKSNGDE GYGRSLRYAA LNLAALHCRF GHYQQADLAL QEAIRIAQES NDHVCLQHCL
SWLYMLEQMK GSDSSVLTED SVKMAAHFCL PYLASLGIQS LVQQGAIGGK AANKLMDALK
DTDILHWKHS LSELIDISLA QTTSIWRMYG KSTMALQQAQ LLLNMNSLEP VNFGVQQNNT
EAFAVALCHL AELHAEQGLF GASAEILKHL KEQFPPHTKH AELWMLCDLK IQFERAMNDG
KYHLAEPHVK AIAALNQTEG LYRKALVLKA QNQTTEAYKV LQQLQQHCEK TKCTEMIIRV
MLATAELHWE SSGFATALPL LLQALALARQ HHLQSLASET ILHLAFSQLM LGVPEQALNI
LHEAMEPILA HGAVVHKGRA LLLVAKCQIA TAGAAPGEHR RAALEMAVQT LDEAAAYFSK
LDCKERLRDV HYLQARVHHS LGRVPERNKC AMLFRLLDQE LPASGAPLIT RL
//
