ID A0A9D3SSP0_9TELE Unreviewed; 874 AA.
AC A0A9D3SSP0;
DT 03-MAY-2023, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2023, sequence version 1.
DT 28-JAN-2026, entry version 15.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
GN ORFNames=KOW79_006285 {ECO:0000313|EMBL:KAG7330063.1};
OS Hemibagrus wyckioides.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Bagridae; Hemibagrus.
OX NCBI_TaxID=337641 {ECO:0000313|EMBL:KAG7330063.1, ECO:0000313|Proteomes:UP000824219};
RN [1] {ECO:0000313|EMBL:KAG7330063.1, ECO:0000313|Proteomes:UP000824219}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EC202008001 {ECO:0000313|EMBL:KAG7330063.1};
RC TISSUE=Blood {ECO:0000313|EMBL:KAG7330063.1};
RA Shao F.;
RT "Chromosome-level genome assembly of the red-tail catfish (Hemibagrus
RT wyckioides).";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] +
CC ADP + H(+); Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:20101, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:61978, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00051243};
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004308}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG7330063.1}.
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DR EMBL; JAHKSW010000007; KAG7330063.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A9D3SSP0; -.
DR OrthoDB; 98077at2759; -.
DR Proteomes; UP000824219; Linkage Group LG07.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0043235; C:receptor complex; IEA:TreeGrafter.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016477; P:cell migration; IEA:TreeGrafter.
DR GO; GO:0007169; P:cell surface receptor protein tyrosine kinase signaling pathway; IEA:TreeGrafter.
DR GO; GO:0001779; P:natural killer cell differentiation; IEA:TreeGrafter.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:TreeGrafter.
DR GO; GO:0007399; P:nervous system development; IEA:TreeGrafter.
DR GO; GO:0006909; P:phagocytosis; IEA:TreeGrafter.
DR GO; GO:0030168; P:platelet activation; IEA:TreeGrafter.
DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:TreeGrafter.
DR CDD; cd00063; FN3; 1.
DR FunFam; 2.10.50.10:FF:000001; Ephrin type-A receptor 5; 1.
DR FunFam; 1.10.510.10:FF:000089; Tyrosine-protein kinase receptor TYRO3; 1.
DR Gene3D; 2.60.40.1770; ephrin a2 ectodomain; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.200.20; Phosphorylase Kinase, domain 1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR001090; Ephrin_rcpt_lig-bd_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR050122; RTK.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR PANTHER; PTHR24416:SF323; TYROSINE-PROTEIN KINASE RECEPTOR UFO; 1.
DR Pfam; PF25599; Ephrin_CRD; 1.
DR Pfam; PF01404; Ephrin_lbd; 1.
DR Pfam; PF07699; Ephrin_rec_like; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00615; EPH_lbd; 1.
DR SMART; SM01411; Ephrin_rec_like; 1.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51550; EPH_LBD; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000824219};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..874
FT /note="receptor protein-tyrosine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5038964058"
FT TRANSMEM 441..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..194
FT /note="Eph LBD"
FT /evidence="ECO:0000259|PROSITE:PS51550"
FT DOMAIN 311..421
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 528..799
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 824..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 560
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 874 AA; 97097 MW; 349C473C8D3DE36B CRC64;
MARALCLLLN YCLVSVTFLG TSAQLTPIEE VILDSTSDGN LQWIPEPPSA WQVIKLKLGL
PSAHSVFQGC EAKLNNTLKT LWINWIAKKD AHELRLDLLF AQNDKIPVRI HILESDIPVE
NLHTGPERDE TVAPQAFTKS SSPQDVETHL YNAQGLDLGK VTKNGFHLGF TYSGSCMFIS
SIRVFYMKCP ELTMNQTRFG AVSAGSGLIR GQCVDGAEEV STPKIVCKSN GEWSEMQRFC
VCGAGYQTEG NICKACGLGT YKAANDSGEC QLCPYNSRTS SEGASECECE KGYARLQDDP
PQLGCTRSPS APLNLTIHHF SNNALILNWA MPADLGGRPE VMYDVECRQK TKESHETWIP
CKNTLLIRPQ SRELTETMAN ITGLHSHMSY QVSVRAYNRI SQKLGTSGSS QFIIIGKTPV
VATSAVPVPT PAAQEQLKTP VIVSVLFVIL LALIPAAFFI YRGYNKFSRF RDEVEVVPLH
DVGTTYRHPE EPQTAPPQQT TSSVQILDSV NRNLLSGIRD VLVDRSRVTL GKELGRGEFG
AVYEGIFLSD DNENIQVAVK TMRVGIYSQD DLQSFLKEAE IMQHFDHDNI VKLLGVTLET
VQDSSIPVPR VILPFLKHGD LRRFLIATRY GDIPMFVPHQ SLLRFMIDIA SGMEYLSSKG
FLHRDLAARN CMLGDDLRVR VADFGLSKQI YSSNYYRQKV AIRMPIKWMA VESLSESIYT
SKSDVWSFGV TMWEIVSRGK TPYPGIPNHE LLELLESGHR LRQGDCDNKL YEVMLSCWHK
EPSKRPCFAK LARILKALLC ELPPLEPSKE NYYINQGLEA ANATQSSAAE PDPEGAAGNI
YLPSPVGKTT CPAEKEERKE TAEDGYLLCS TSGI
//
