ID A0A9D3T323_MEGAT Unreviewed; 1149 AA.
AC A0A9D3T323;
DT 03-MAY-2023, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2023, sequence version 1.
DT 10-JUN-2026, entry version 13.
DE RecName: Full=Rho GTPase-activating protein 20 {ECO:0000256|ARBA:ARBA00070254};
DE AltName: Full=Rho-type GTPase-activating protein 20 {ECO:0000256|ARBA:ARBA00083374};
GN ORFNames=MATL_G00151450 {ECO:0000313|EMBL:KAG7467253.1};
OS Megalops atlanticus (Tarpon) (Clupea gigantea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Elopiformes; Megalopidae; Megalops.
OX NCBI_TaxID=7932 {ECO:0000313|EMBL:KAG7467253.1, ECO:0000313|Proteomes:UP001046870};
RN [1] {ECO:0000313|EMBL:KAG7467253.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=YG-15Mar2019-1 {ECO:0000313|EMBL:KAG7467253.1};
RC TISSUE=Brain {ECO:0000313|EMBL:KAG7467253.1};
RA Zahm M., Roques C., Cabau C., Klopp C., Donnadieu C., Jouanno E.,
RA Lampietro C., Louis A., Herpin A., Echchiki A., Berthelot C., Parey E.,
RA Roest-Crollius H., Braasch I., Postlethwait J., Bobe J., Montfort J.,
RA Bouchez O., Begum T., Mejri S., Adams A., Chen W.-J., Guiguen Y.;
RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: GTPase activator for the Rho-type GTPases by converting them
CC to an inactive GDP-bound state. {ECO:0000256|ARBA:ARBA00055252}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG7467253.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JAFDVH010000012; KAG7467253.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A9D3T323; -.
DR OrthoDB; 9994905at2759; -.
DR Proteomes; UP001046870; Chromosome 12.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13319; PH_RARhoGAP; 1.
DR CDD; cd17115; RA_RHG20; 1.
DR CDD; cd04402; RhoGAP_ARHGAP20; 1.
DR FunFam; 2.30.29.30:FF:000217; Rho GTPase activating protein 20; 1.
DR FunFam; 1.10.555.10:FF:000025; Rho GTPase-activating protein 20; 1.
DR Gene3D; 3.10.20.90; Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR047886; ARHGAP20-like_RhoGAP.
DR InterPro; IPR047887; ARHGAP20_PH.
DR InterPro; IPR047888; ARHGAP20_RA.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23179:SF28; RHO GTPASE-ACTIVATING PROTEIN 20; 1.
DR PANTHER; PTHR23179; T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF22286; RHG20_PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00172}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP001046870}.
FT DOMAIN 195..277
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 364..553
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 868..926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1007..1083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..599
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..616
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..750
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..786
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 817..841
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 905..917
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1037..1050
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1061..1070
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1149 AA; 126798 MW; E89E3B5E35BA732F CRC64;
METMSPQQES TGQSRSASLT GETKICTLPE NKKKMKSLTQ RRQSAPSLVI SKALTKSRTL
SRENCLSPIS PETCPLVQSF LTPSRTFVTH GHAQLKTGLQ TQERHLFLFN DILLIAKAKS
STHFKLKAQV RVCEMWTASC MEDVCEGSTN PERSFVMGWP TFNCVATFSS VEQKERWLSF
IKSRIKEEKE KDDPKTILLK IFAKDIADCA HAKTLTVSHS DCASEVTRMT LQQFGISGSE
KDYQLWVSSR KDEPPYPLIG HEFPFSIRMS YIRERVSHAT GVKDPITPPD LQGALEQLPM
DTQCQFILKP SRMATGQSLM EPAQKPLRRK RSFMNWAFWR GSSSQLDGLP VSPTSPAPGR
LFGLPLSAVC EGGALPKPVM DMLTFLFREG PFTRGIFRRS ASAKACREMR DRLNSGTDSL
PLTCESIFVI AAVFKDFLRN IPGSLLSQDL YEHWVGVMDQ AGEGEEDRVQ AIQRLVQRLP
RENQLLLSHM LAVLHCIQRH SHHNQMNSFN LSVCIAPSML WAPAPCNPDM ESEGTKKVSE
VVRFMIENCC RVLGDSITSL FGGFPQNGSS IDHRSDASAV QLNDSSYDSL ENELNDDTES
PCQDLRGRKD KQENLSRDSV ITLSDCDLDQ PDPDPAPVQL QLPPLARPRR VTLAVHQPHP
HAHRDAPQRK SLCPLGARRL RRCSEPAIGH LPLCPAPPPG QHGAVARKTS YDAVTDHVED
EVFVERLQLD GRAGAGSGGG AEDRRDSRDA PRRRHKQPPP LQLDASCSSL SSPTTSPSGS
SMSSLDSAFS QFSTDYNVLA PSDGRGGTLR AQGSSTSRSQ ASPVSPASVS PCSLAPVPSL
STACPREASD WSHHRAADGL HPNTWLKKDH RLSLRQQDRG DWEDTGGSPE RPLISNGSTE
ALLNGERKAS ELEDLSKRRS SSPPSYPQAL LLQCSKSLFC KGKDKVLTVK ELRQLHDQAA
TRSSGSDAAP MITSAARSNL PQGVFYGHSS SCLTLQRQKS HSLITAGEVS GRNPAGGRRV
SEPLVDSCSM GRSSTSDLEK LHRQALDHRG KAPAGRTQQD SCRKGPDAEP LHGSTNQNPE
PRFCLSPSAT QTVKDYFSLT HTDPDTCLRR SQEVAIAIVQ GKRDWQSRRC SDPRIDDFDQ
MFFAEESYV
//
