ID A0A9D3TDK9_MEGAT Unreviewed; 900 AA.
AC A0A9D3TDK9;
DT 03-MAY-2023, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2023, sequence version 1.
DT 18-JUN-2025, entry version 10.
DE RecName: Full=Exocyst complex component 1 {ECO:0000256|ARBA:ARBA00068988};
DE AltName: Full=Exocyst complex component Sec3 {ECO:0000256|ARBA:ARBA00079611};
GN ORFNames=MATL_G00038950 {ECO:0000313|EMBL:KAG7488858.1};
OS Megalops atlanticus (Tarpon) (Clupea gigantea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Elopiformes; Megalopidae; Megalops.
OX NCBI_TaxID=7932 {ECO:0000313|EMBL:KAG7488858.1, ECO:0000313|Proteomes:UP001046870};
RN [1] {ECO:0000313|EMBL:KAG7488858.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=YG-15Mar2019-1 {ECO:0000313|EMBL:KAG7488858.1};
RC TISSUE=Brain {ECO:0000313|EMBL:KAG7488858.1};
RA Zahm M., Roques C., Cabau C., Klopp C., Donnadieu C., Jouanno E.,
RA Lampietro C., Louis A., Herpin A., Echchiki A., Berthelot C., Parey E.,
RA Roest-Crollius H., Braasch I., Postlethwait J., Bobe J., Montfort J.,
RA Bouchez O., Begum T., Mejri S., Adams A., Chen W.-J., Guiguen Y.;
RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC exocytic vesicles with fusion sites on the plasma membrane.
CC {ECO:0000256|ARBA:ARBA00002660}.
CC -!- SUBUNIT: The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4,
CC EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with EEF1A1. Interacts with
CC SLC6A9; interaction increases the transporter capacity of SLC6A9
CC probably by promoting its insertion into the cell membrane.
CC {ECO:0000256|ARBA:ARBA00061758}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}. Midbody,
CC Midbody ring {ECO:0000256|ARBA:ARBA00004476}.
CC -!- SIMILARITY: Belongs to the SEC3 family.
CC {ECO:0000256|ARBA:ARBA00006518}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG7488858.1}.
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DR EMBL; JAFDVH010000002; KAG7488858.1; -; Genomic_DNA.
DR OrthoDB; 27109at2759; -.
DR Proteomes; UP001046870; Chromosome 2.
DR GO; GO:0000145; C:exocyst; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:TreeGrafter.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR GO; GO:0006893; P:Golgi to plasma membrane transport; IEA:TreeGrafter.
DR CDD; cd14683; PH-EXOC1; 1.
DR FunFam; 2.30.29.90:FF:000001; exocyst complex component 1 isoform X1; 1.
DR Gene3D; 2.30.29.90; -; 1.
DR InterPro; IPR028258; Sec3-PIP2_bind.
DR InterPro; IPR048628; Sec3_C.
DR InterPro; IPR019160; Sec3_CC.
DR PANTHER; PTHR16092:SF14; EXOCYST COMPLEX COMPONENT 1 ISOFORM X1; 1.
DR PANTHER; PTHR16092; SEC3/SYNTAXIN-RELATED; 1.
DR Pfam; PF15277; Sec3-PIP2_bind; 1.
DR Pfam; PF20654; Sec3_C-term; 1.
DR Pfam; PF09763; Sec3_CC; 1.
DR SMART; SM01313; Sec3-PIP2_bind; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP001046870};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 31..122
FT /note="Exocyst complex component Sec3 PIP2-binding N-
FT terminal"
FT /evidence="ECO:0000259|SMART:SM01313"
FT REGION 141..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 213..261
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 451..465
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..480
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..497
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 900 AA; 102832 MW; D79689A3C72FE94A CRC64;
MTAIKHALQR DIFTPNDERL LSIVNVCKAG KKKKNCFLCA TVTTERPVQV KVVKVKKSDK
GDFYKRQVAW ELRDLTEVDA KDANKENPEF DLHFEKVYKW VASSTAEKNS FISCIWKLNQ
RYLRKKVEFV NVSPQLLEEL PKAEESVPSG ENQSVAGGDE DALDDYQELN AREEQDIENM
MEVCEYAISN AEAFAEKLSR ELQVLDGANI QSIMASEKQV NILMQLLDEA LAEVDTIEGK
LSSYEEMLQS VKEQMDQISQ SNRLIQLSST NNLRLLDEIN FLVNYMDLSK GHIRALQEGD
LSSPKGIEAC INASEALLQC MNVALRPGHD KLLAVKQQQH LFNELRDSFS RRLTNHLNNV
FVHQGHDQSS SLSQHSAELM LPKHNVLHRD LLRYAKLMEW LKNTQREKYE GLTGTYVDYM
TRLYEREIKD FFEVAKMKIA GTSKEGKKFA TLPRKESALK QETESLHGSS GKLTGSTSSL
NKLTVQGSSS RRSQSSSLLD MGNMSASDLD VADRTKFDKI FEQVLSELEP LCLAEQDFIS
KFFKLQQHPS QGVPQGEMSE AEGTVHSRLS SAGEHRHSMS EKDMVRLMMN NIFHCIEVEL
NSLIALGDKM DSFHSLYMLV KMSHHVWTAE NVDPASYLST TLGNVLVTVK RNFDKCISSQ
IRQMEEVKIS KKSKVGILPF VTGFEEFAEL AETIFRNAER RGDLDKAYVK LIRAVYMNVE
KVASESLKTP RDVVLMENFH HIFSTLSRLK ISCLETERRE AKHKYTEHLQ AYVITSLGQP
LEKLNHFFEG VEARVAQGVR EEEVSYQLAF SKQELRKVIK EYPGKEVKKG LDNLYKKVDK
HLCEEENLLQ VVWHSMQDEF IRQYKHFVGL IGRCYPGSGI TMDFTIQDIL EYFSSIAQSH
//
