ID   A0A9D3TEG6_MEGAT        Unreviewed;       144 AA.
AC   A0A9D3TEG6;
DT   03-MAY-2023, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2023, sequence version 1.
DT   05-FEB-2025, entry version 11.
DE   RecName: Full=Adrenomedullin {ECO:0008006|Google:ProtNLM};
GN   ORFNames=MATL_G00011250 {ECO:0000313|EMBL:KAG7492132.1};
OS   Megalops atlanticus (Tarpon) (Clupea gigantea).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Elopiformes; Megalopidae; Megalops.
OX   NCBI_TaxID=7932 {ECO:0000313|EMBL:KAG7492132.1, ECO:0000313|Proteomes:UP001046870};
RN   [1] {ECO:0000313|EMBL:KAG7492132.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=YG-15Mar2019-1 {ECO:0000313|EMBL:KAG7492132.1};
RC   TISSUE=Brain {ECO:0000313|EMBL:KAG7492132.1};
RA   Zahm M., Roques C., Cabau C., Klopp C., Donnadieu C., Jouanno E.,
RA   Lampietro C., Louis A., Herpin A., Echchiki A., Berthelot C., Parey E.,
RA   Roest-Crollius H., Braasch I., Postlethwait J., Bobe J., Montfort J.,
RA   Bouchez O., Begum T., Mejri S., Adams A., Chen W.-J., Guiguen Y.;
RL   Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the adrenomedullin family.
CC       {ECO:0000256|ARBA:ARBA00010575}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAG7492132.1}.
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DR   EMBL; JAFDVH010000001; KAG7492132.1; -; Genomic_DNA.
DR   OrthoDB; 8854792at2759; -.
DR   Proteomes; UP001046870; Chromosome 1.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:TreeGrafter.
DR   GO; GO:0010460; P:positive regulation of heart rate; IEA:TreeGrafter.
DR   GO; GO:0003073; P:regulation of systemic arterial blood pressure; IEA:TreeGrafter.
DR   InterPro; IPR051665; Adrenomedullin-reg_peptide.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   PANTHER; PTHR23414; ADRENOMEDULLIN, ADM; 1.
DR   PANTHER; PTHR23414:SF6; ADRENOMEDULLIN-5-LIKE PROTEIN-RELATED; 1.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR621116-50};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP001046870};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          75..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          125..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        83..92
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        107..112
FT                   /evidence="ECO:0000256|PIRSR:PIRSR621116-50"
SQ   SEQUENCE   144 AA;  15905 MW;  CB151388F9962D09 CRC64;
     MKGAWEVKSD NSHTSLELTS MIIFLQLTAL LVTVLLTKAT PLRPSQHRSL QQATSSLERG
     IQRLQVEKLE DEQGGQILGS MALQDTTGQT DSAESRIRSR RAPQRGCQLG TCQLHNLANT
     LYRIGQTNGK DESKKANDPQ GYGR
//