ID A0A9D3X593_9SAUR Unreviewed; 521 AA.
AC A0A9D3X593;
DT 03-MAY-2023, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2023, sequence version 1.
DT 02-APR-2025, entry version 10.
DE RecName: Full=ERBB receptor feedback inhibitor 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=KIL84_022154 {ECO:0000313|EMBL:KAH1175629.1};
OS Mauremys mutica (yellowpond turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Geoemydidae; Geoemydinae; Mauremys.
OX NCBI_TaxID=74926 {ECO:0000313|EMBL:KAH1175629.1, ECO:0000313|Proteomes:UP000827986};
RN [1] {ECO:0000313|EMBL:KAH1175629.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MM-2020 {ECO:0000313|EMBL:KAH1175629.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAH1175629.1};
RA Gong S., Gao Y.;
RT "The genome of Mauremys mutica provides insights into the evolution of
RT semi-aquatic lifestyle.";
RL Submitted (SEP-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Endomembrane system
CC {ECO:0000256|ARBA:ARBA00029433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00029433}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00029433}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAH1175629.1}.
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DR EMBL; JAHDVG010000476; KAH1175629.1; -; Genomic_DNA.
DR OrthoDB; 9931672at2759; -.
DR Proteomes; UP000827986; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; IEA:TreeGrafter.
DR GO; GO:0045616; P:regulation of keratinocyte differentiation; IEA:TreeGrafter.
DR InterPro; IPR015116; Cdc42-bd-like.
DR InterPro; IPR052112; EGFR_SigReg_Kinase.
DR InterPro; IPR021619; Mig-6.
DR PANTHER; PTHR14254:SF5; ERBB RECEPTOR FEEDBACK INHIBITOR 1; 1.
DR PANTHER; PTHR14254; GENE 33 POLYPEPTIDE; 1.
DR Pfam; PF09027; GTPase_binding; 1.
DR Pfam; PF11555; Inhibitor_Mig-6; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000827986}.
FT DOMAIN 63..113
FT /note="Cdc42 binding"
FT /evidence="ECO:0000259|Pfam:PF09027"
FT DOMAIN 374..429
FT /note="Mig-6"
FT /evidence="ECO:0000259|Pfam:PF11555"
FT REGION 145..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..155
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..167
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..352
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..384
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 521 AA; 57151 MW; 983198DFEBF90DFA CRC64;
MYWDRASGAG VWRMRSVPQG GQGYAEPGRC LGNESCRVPG ENCGFLKFGD IAEQGTMSTA
GVAAQEMRGP LKTGFLHNGQ GIGSLKTCWS SHNGFEKTFF NVEPIAMPYN LNPSAQQNCT
CVGHISNPVP TNGYCFTESC VRVSPQKSSP SPLSPKSEKL SSKHEDHLVP SFSKLSVTVG
CVSEEMLPHT PTKSGPPQFS SASSNDRSSR PLPPLPIFED FSPDDVDREV EFLTSSDTDF
LLDDYGLPPF KSSAPSRRSF RGCGQINYAY FDAPAGPKSE DANSTTNLNG CTQTPCPPPQ
QQHRRLRRSH SGPAGSFNKP VVRLSSHLNR ASPNSDEDKP EVPPRVPIPP RVLKPDYRRW
SAEVASSAYS DEDRPPKVPP REPLSRSNSR TPSPKSLPLY LNGVMPPTQS FAPDPKYVSS
KALQRQNSDG SANRVPCILP IIENGKKASS THYYLLPERP SYLDKYEKFF REAEEISTST
EMKSWSGDCT TAAATAKEDS KARMDMVGHV KRKHLSYVVS P
//
