ID   A0A9D3XF77_9SAUR        Unreviewed;       275 AA.
AC   A0A9D3XF77;
DT   03-MAY-2023, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2023, sequence version 1.
DT   02-APR-2025, entry version 9.
DE   RecName: Full=Insulin-induced gene protein {ECO:0000256|RuleBase:RU241113};
GN   ORFNames=KIL84_012258 {ECO:0000313|EMBL:KAH1178556.1};
OS   Mauremys mutica (yellowpond turtle).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC   Testudinoidea; Geoemydidae; Geoemydinae; Mauremys.
OX   NCBI_TaxID=74926 {ECO:0000313|EMBL:KAH1178556.1, ECO:0000313|Proteomes:UP000827986};
RN   [1] {ECO:0000313|EMBL:KAH1178556.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=MM-2020 {ECO:0000313|EMBL:KAH1178556.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:KAH1178556.1};
RA   Gong S., Gao Y.;
RT   "The genome of Mauremys mutica provides insights into the evolution of
RT   semi-aquatic lifestyle.";
RL   Submitted (SEP-2021) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates feedback control of cholesterol synthesis.
CC       {ECO:0000256|RuleBase:RU241113}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU241113}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC       ECO:0000256|RuleBase:RU241113}.
CC   -!- SIMILARITY: Belongs to the INSIG family.
CC       {ECO:0000256|ARBA:ARBA00007475, ECO:0000256|RuleBase:RU241113}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAH1178556.1}.
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DR   EMBL; JAHDVG010000474; KAH1178556.1; -; Genomic_DNA.
DR   OrthoDB; 205546at2759; -.
DR   Proteomes; UP000827986; Unassembled WGS sequence.
DR   GO; GO:0032937; C:SREBP-SCAP-Insig complex; IEA:TreeGrafter.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0032869; P:cellular response to insulin stimulus; IEA:TreeGrafter.
DR   GO; GO:0006695; P:cholesterol biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0032933; P:SREBP signaling pathway; IEA:TreeGrafter.
DR   GO; GO:0036316; P:SREBP-SCAP complex retention in endoplasmic reticulum; IEA:TreeGrafter.
DR   InterPro; IPR025929; INSIG_fam.
DR   PANTHER; PTHR15301; INSULIN-INDUCED GENE 1; 1.
DR   PANTHER; PTHR15301:SF11; INSULIN-INDUCED GENE 1 PROTEIN; 1.
DR   Pfam; PF07281; INSIG; 1.
PE   3: Inferred from homology;
KW   Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548,
KW   ECO:0000256|RuleBase:RU241113};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW   ECO:0000256|RuleBase:RU241113};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW   ECO:0000256|RuleBase:RU241113};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU241113};
KW   Reference proteome {ECO:0000313|Proteomes:UP000827986};
KW   Steroid metabolism {ECO:0000256|ARBA:ARBA00023221,
KW   ECO:0000256|RuleBase:RU241113};
KW   Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU241113};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU241113}.
FT   TRANSMEM        87..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU241113"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU241113"
FT   TRANSMEM        181..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU241113"
FT   TRANSMEM        209..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU241113"
FT   TRANSMEM        240..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU241113"
FT   REGION          48..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..73
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   275 AA;  29836 MW;  C06019B62D3FE5FD CRC64;
     MVKPMPRLEN CTWSCSCAAR GRHKNQLGKT AVGLAAKVGE MLSSSVSSSP LTLVDHGTRT
     PSASSLRSSS SSTSSLNLNQ HLVQRSLVLF AVGAFMALVL NLLQIQRNVT LFPEEVIATI
     FSSAWWVPPC CGTAAAVVGL LYPCIDSHLG EPHKFKREWA SVMRCIAVFV GINHASAKLD
     FANNIQLSLT LAALSLGLWW TFDRSRSGLG LGITIAFLAT LITQFLVYNG VYQYTSPDFL
     YIRSWLPCIF FSGGVTVGNI GRQLAMGIPE KPHTD
//