ID A0A9D3XJ94_9SAUR Unreviewed; 1063 AA.
AC A0A9D3XJ94;
DT 03-MAY-2023, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2023, sequence version 1.
DT 18-JUN-2025, entry version 10.
DE RecName: Full=Huntingtin-interacting protein 1-related protein {ECO:0000256|ARBA:ARBA00073599};
GN ORFNames=KIL84_009174 {ECO:0000313|EMBL:KAH1180338.1};
OS Mauremys mutica (yellowpond turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Geoemydidae; Geoemydinae; Mauremys.
OX NCBI_TaxID=74926 {ECO:0000313|EMBL:KAH1180338.1, ECO:0000313|Proteomes:UP000827986};
RN [1] {ECO:0000313|EMBL:KAH1180338.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MM-2020 {ECO:0000313|EMBL:KAH1180338.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAH1180338.1};
RA Gong S., Gao Y.;
RT "The genome of Mauremys mutica provides insights into the evolution of
RT semi-aquatic lifestyle.";
RL Submitted (SEP-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of clathrin-coated pits and vesicles, that may link
CC the endocytic machinery to the actin cytoskeleton. Binds 3-
CC phosphoinositides (via ENTH domain). May act through the ENTH domain to
CC promote cell survival by stabilizing receptor tyrosine kinases
CC following ligand-induced endocytosis. {ECO:0000256|ARBA:ARBA00059997}.
CC -!- SUBUNIT: Homodimer. Interacts with actin; homodimerization promotes
CC actin binding. Interacts with CLTB. Interacts with HIP1. Interacts (via
CC ENTH and I/LWEQ domains) with BCL2L10. {ECO:0000256|ARBA:ARBA00061714}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}. Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004156}.
CC -!- SIMILARITY: Belongs to the SLA2 family.
CC {ECO:0000256|ARBA:ARBA00010135}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAH1180338.1}.
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DR EMBL; JAHDVG010000470; KAH1180338.1; -; Genomic_DNA.
DR OrthoDB; 8178130at2759; -.
DR Proteomes; UP000827986; Unassembled WGS sequence.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:TreeGrafter.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IEA:TreeGrafter.
DR GO; GO:0051015; F:actin filament binding; IEA:TreeGrafter.
DR GO; GO:0035615; F:clathrin adaptor activity; IEA:TreeGrafter.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:TreeGrafter.
DR GO; GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IEA:TreeGrafter.
DR GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:TreeGrafter.
DR GO; GO:0007015; P:actin filament organization; IEA:TreeGrafter.
DR GO; GO:0048268; P:clathrin coat assembly; IEA:TreeGrafter.
DR GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR CDD; cd17014; ANTH_N_HIP1R; 1.
DR FunFam; 1.20.1410.10:FF:000002; Huntingtin interacting protein 1; 1.
DR FunFam; 1.20.5.1700:FF:000002; Huntingtin interacting protein 1; 1.
DR FunFam; 1.25.40.90:FF:000012; Huntingtin interacting protein 1-related; 1.
DR Gene3D; 1.20.5.1700; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 6.10.250.920; -; 1.
DR Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR InterPro; IPR011417; ANTH_dom.
DR InterPro; IPR013809; ENTH.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR032422; HIP1_clath-bd.
DR InterPro; IPR035964; I/LWEQ_dom_sf.
DR InterPro; IPR002558; ILWEQ_dom.
DR InterPro; IPR030224; Sla2_fam.
DR PANTHER; PTHR10407; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR10407:SF10; HUNTINGTIN-INTERACTING PROTEIN 1-RELATED PROTEIN; 1.
DR Pfam; PF07651; ANTH; 1.
DR Pfam; PF16515; HIP1_clath_bdg; 1.
DR Pfam; PF01608; I_LWEQ; 1.
DR SMART; SM00273; ENTH; 1.
DR SMART; SM00307; ILWEQ; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF109885; I/LWEQ domain; 1.
DR PROSITE; PS50942; ENTH; 1.
DR PROSITE; PS50945; I_LWEQ; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000827986}.
FT DOMAIN 23..151
FT /note="ENTH"
FT /evidence="ECO:0000259|PROSITE:PS50942"
FT DOMAIN 769..1010
FT /note="I/LWEQ"
FT /evidence="ECO:0000259|PROSITE:PS50945"
FT COILED 347..613
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 969..1005
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1063 AA; 120546 MW; C1209B605C70165A CRC64;
MNTIKNVPAR VLSRRPGHSL EAEREQFDKT QAMSISKAIN TQEAPVKEKH ARRIILGTHH
EKGAFTFWSY AIGLPLPSSS ILSWKFCHVL HKVLRDGHPN VLQDCQRYRS NIRETGDLWG
HLHDRYGQLV NIYTKLLLTK ISFHLKHPDF PPGLEVTDEV LEKAAGTDVN NIFQLTVEMF
DYMDCELKLT ESVLRQLNTA MAVSQMSSVQ CRLAPLIQVI QDCSHLYHYT VQLMFKLHAC
LPADTLQGHR DRFHEQFRSL KNFFKRASDM LYFKRLIQIP RLPESPPNFL RASALAEHVK
PVVVIPEEAP EDEEPENLIE ISTAPPVEQQ NVSDIFEQTF GPPNGVRDDR DLQIENLKKE
VDLLRAELEK IKLEAQRYIT QLKAQINSLE AELEEQRKQK QKALVDNEQL RDEVERLQRA
QLESSRTQGL YVEAEKKASA TEMRYAKLKE KHSELINTHA ELLRKNADTA KQLTVTQQSQ
EEVARVKEQL AFQMEQVKRE SEMKLEDQTL QMEQLKRELE AKKEELTQIQ SSLSHSKQAG
SELHSQVEAL HAEKDSLRKS VSEKECELLS VKGLIQEKEL LLNQEAERSA KEIRELQGKL
MEKKNQEQSL QQKLLDDQFG MLQGTVKEAE NIIQDAIAKL DDPLHVRCTS SPDYLISRAQ
AALESVHSLE NGHGQYVTNM TDATGLVAAL AQFAHLTADT IVNGSATSHM APTDHADKLI
ETCRACGHRS LGYLNELKDK QLLRQANPED VRRTLQGILQ LGQELRPKSL DIKQEELGDM
VDKEMSSTSA AIEDAVRRIE EMMNQARNKS SGVKLEVNER ILNSCTDLMK AIRLLVMTST
NLQKEIVESG RGAATTQEFY AKNSRWTEGL ISASKAVGWG ATQLVESADR VVLHTGKYEE
LIVCSHEIAA STAQLVAASK VKADKNSRNL GKLQECSRNV NEMAANVVAS TKSGQEQIED
KDTMDFSGMS LIKLKKEEME TQVKVLELEK KLENERIRLG ELRKKHYALA GVYEDPDEGK
LAVAPRRSIL KKPPLAQKPA YPLKQDCELE QHDGVFQARI VNF
//
