ID A0A9D3Z5J6_DREPO Unreviewed; 396 AA.
AC A0A9D3Z5J6;
DT 03-MAY-2023, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2023, sequence version 1.
DT 27-NOV-2024, entry version 7.
DE RecName: Full=Protein CLP1 homolog {ECO:0000256|HAMAP-Rule:MF_03035};
GN ORFNames=DPMN_070509 {ECO:0000313|EMBL:KAH3711010.1};
OS Dreissena polymorpha (Zebra mussel) (Mytilus polymorpha).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Heteroconchia; Euheterodonta; Imparidentia; Neoheterodontei;
OC Myida; Dreissenoidea; Dreissenidae; Dreissena.
OX NCBI_TaxID=45954 {ECO:0000313|EMBL:KAH3711010.1, ECO:0000313|Proteomes:UP000828390};
RN [1] {ECO:0000313|EMBL:KAH3711010.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Duluth1 {ECO:0000313|EMBL:KAH3711010.1};
RC TISSUE=Whole animal {ECO:0000313|EMBL:KAH3711010.1};
RA McCartney M.A., Auch B., Kono T., Mallez S., Zhang Y., Obille A.,
RA Becker A., Abrahante J.E., Garbe J., Badalamenti J.P., Herman A.,
RA Mangelson H., Liachko I., Sullivan S., Sone E.D., Koren S.,
RA Silverstein K.A.T., Beckman K.B., Gohl D.M.;
RT "The Genome of the Zebra Mussel, Dreissena polymorpha: A Resource for
RT Invasive Species Research.";
RL bioRxiv 0:0-0(2019).
RN [2] {ECO:0000313|EMBL:KAH3711010.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Duluth1 {ECO:0000313|EMBL:KAH3711010.1};
RC TISSUE=Whole animal {ECO:0000313|EMBL:KAH3711010.1};
RA McCartney M.A., Auch B., Kono T., Mallez S., Becker A., Gohl D.M.,
RA Silverstein K.A.T., Koren S., Bechman K.B., Herman A., Abrahante J.E.,
RA Garbe J.;
RL Submitted (NOV-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for endonucleolytic cleavage during polyadenylation-
CC dependent pre-mRNA 3'-end formation. {ECO:0000256|HAMAP-Rule:MF_03035}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|HAMAP-Rule:MF_03035}.
CC -!- SIMILARITY: Belongs to the Clp1 family. Clp1 subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_03035}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_03035}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAH3711010.1}.
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DR EMBL; JAIWYP010000014; KAH3711010.1; -; Genomic_DNA.
DR Proteomes; UP000828390; Unassembled WGS sequence.
DR GO; GO:0005849; C:mRNA cleavage factor complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; IEA:InterPro.
DR GO; GO:0031124; P:mRNA 3'-end processing; IEA:UniProtKB-UniRule.
DR GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; IEA:TreeGrafter.
DR FunFam; 2.40.30.330:FF:000001; Protein CLP1 homolog; 1.
DR FunFam; 3.40.50.300:FF:000454; Protein CLP1 homolog; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.330; Pre-mRNA cleavage complex subunit Clp1, C-terminal domain; 1.
DR HAMAP; MF_03035; Clp1; 1.
DR InterPro; IPR028606; Clp1.
DR InterPro; IPR045116; Clp1/Grc3.
DR InterPro; IPR010655; Clp1_C.
DR InterPro; IPR038238; Clp1_C_sf.
DR InterPro; IPR032324; Clp1_N.
DR InterPro; IPR032319; CLP1_P.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12755; CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P; 1.
DR PANTHER; PTHR12755:SF6; POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1; 1.
DR Pfam; PF06807; Clp1; 1.
DR Pfam; PF16573; CLP1_N; 2.
DR Pfam; PF16575; CLP1_P; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_03035};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664, ECO:0000256|HAMAP-
KW Rule:MF_03035};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_03035};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|HAMAP-Rule:MF_03035};
KW Reference proteome {ECO:0000313|Proteomes:UP000828390}.
FT DOMAIN 13..49
FT /note="Clp1 N-terminal beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF16573"
FT DOMAIN 48..77
FT /note="Clp1 N-terminal beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF16573"
FT DOMAIN 92..278
FT /note="Polyribonucleotide 5'-hydroxyl-kinase Clp1 P-loop"
FT /evidence="ECO:0000259|Pfam:PF16575"
FT DOMAIN 283..394
FT /note="Pre-mRNA cleavage complex subunit Clp1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06807"
FT BINDING 18
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03035"
FT BINDING 95..100
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03035"
SQ SEQUENCE 396 AA; 43999 MW; 7BA6CB5F04D2728A CRC64;
MTEKEQGVED FQLVKESELR FEVESKSKVT LELVSGKAEI FGSELAIGKT EVAYISQETP
MVVYLNTHVA LEQMRMKSEE DTSRGPRIMI CGPTDVGKST LCNLLLNYGV RLGRAPMLVD
LDVGQGQVSI PCTMGAFTVE RPSDLEEGFS QSAPIVFHFG HTSPTKNLTL YNLLVARVAD
VINMKCDTFK KVNHSGVIIN TGGWVRGSGY DSLKHTAGSF EVDIIAILDQ ERLYTEMKRD
MPDFVQIILL PKSGGVVERS SNQRSDARDS AIRNYFYGPK NTLFPHTFEV KCSEIKIYKI
GAPSLPDSCL PLGMKPQDNK TKLVPLLPST SLLHHVYSVS SAESAEENVI EANVIGFVVF
TEYHQDRNSF TVLSPAPHPL PRPILLQTEL QFMDIH
//
