ID A0A9D4AZ35_9SAUR Unreviewed; 229 AA.
AC A0A9D4AZ35;
DT 03-MAY-2023, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2023, sequence version 1.
DT 18-JUN-2025, entry version 9.
DE RecName: Full=Bcl-2-like protein 1 {ECO:0000256|ARBA:ARBA00013629};
DE AltName: Full=Apoptosis regulator Bcl-X {ECO:0000256|ARBA:ARBA00030811};
GN ORFNames=KIL84_009626 {ECO:0000313|EMBL:KAH1181872.1};
OS Mauremys mutica (yellowpond turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Geoemydidae; Geoemydinae; Mauremys.
OX NCBI_TaxID=74926 {ECO:0000313|EMBL:KAH1181872.1, ECO:0000313|Proteomes:UP000827986};
RN [1] {ECO:0000313|EMBL:KAH1181872.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MM-2020 {ECO:0000313|EMBL:KAH1181872.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAH1181872.1};
RA Gong S., Gao Y.;
RT "The genome of Mauremys mutica provides insights into the evolution of
RT semi-aquatic lifestyle.";
RL Submitted (SEP-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, secretory
CC vesicle, synaptic vesicle membrane {ECO:0000256|ARBA:ARBA00004432}.
CC Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305}. Mitochondrion
CC membrane {ECO:0000256|ARBA:ARBA00004325}. Nucleus membrane
CC {ECO:0000256|ARBA:ARBA00004528}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004528}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004528}.
CC -!- SIMILARITY: Belongs to the Bcl-2 family.
CC {ECO:0000256|ARBA:ARBA00009458}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAH1181872.1}.
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DR EMBL; JAHDVG010000467; KAH1181872.1; -; Genomic_DNA.
DR OrthoDB; 6021377at2759; -.
DR Proteomes; UP000827986; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:TreeGrafter.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051400; F:BH domain binding; IEA:TreeGrafter.
DR GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:TreeGrafter.
DR GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IEA:TreeGrafter.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0001836; P:release of cytochrome c from mitochondria; IEA:TreeGrafter.
DR CDD; cd06845; Bcl-2_like; 1.
DR FunFam; 1.10.437.10:FF:000003; Bcl-2-like protein 1; 1.
DR Gene3D; 1.10.437.10; Blc2-like; 1.
DR InterPro; IPR013279; Apop_reg_BclX.
DR InterPro; IPR036834; Bcl-2-like_sf.
DR InterPro; IPR046371; Bcl-2_BH1-3.
DR InterPro; IPR026298; Bcl-2_fam.
DR InterPro; IPR002475; Bcl2-like.
DR InterPro; IPR004725; Bcl2/BclX.
DR InterPro; IPR020717; Bcl2_BH1_motif_CS.
DR InterPro; IPR020726; Bcl2_BH2_motif_CS.
DR InterPro; IPR020728; Bcl2_BH3_motif_CS.
DR InterPro; IPR003093; Bcl2_BH4.
DR NCBIfam; TIGR00865; bcl-2; 1.
DR PANTHER; PTHR11256; BCL-2 RELATED; 1.
DR PANTHER; PTHR11256:SF12; BCL-2-LIKE PROTEIN 1; 1.
DR Pfam; PF00452; Bcl-2; 1.
DR Pfam; PF02180; BH4; 1.
DR PRINTS; PR01864; APOPREGBCLX.
DR PRINTS; PR01862; BCL2FAMILY.
DR SMART; SM00337; BCL; 1.
DR SMART; SM00265; BH4; 1.
DR SUPFAM; SSF56854; Bcl-2 inhibitors of programmed cell death; 1.
DR PROSITE; PS50062; BCL2_FAMILY; 1.
DR PROSITE; PS01080; BH1; 1.
DR PROSITE; PS01258; BH2; 1.
DR PROSITE; PS01259; BH3; 1.
DR PROSITE; PS50063; BH4_2; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703, ECO:0000256|PROSITE-
KW ProRule:PRU00025}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000827986};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 209..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..24
FT /note="Apoptosis regulator Bcl-2 family BH4"
FT /evidence="ECO:0000259|PROSITE:PS50063"
FT REGION 35..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 5..24
FT /note="BH4"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00025"
SQ SEQUENCE 229 AA; 25606 MW; 1D337C355E4C2E55 CRC64;
MSNTNRELVI DFLSYKLSQR GYSWSRFEGE DEIRTDSAEE AEMASVPNGS PSWHPGASHI
VNGAAGHSNS LEAHERVPAT GVRDALREAG DEFELRYRRA FSDLTSQLHI TPGTAYQSFE
QVVNELFRDG VNWGRIVAFF SFGGALCVES VDKEMQVLVG RIVSWMTTYL TDHLDPWIQE
NGGWERFVDL YGNDAAAKSR KGQEQFNRWL LTGATLAGVL LLGSLLSRK
//
