ID   A0A9D5DDS0_9LILI        Unreviewed;       129 AA.
AC   A0A9D5DDS0;
DT   03-MAY-2023, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2023, sequence version 1.
DT   05-FEB-2025, entry version 7.
DE   RecName: Full=cysteine dioxygenase {ECO:0000256|ARBA:ARBA00013133};
DE            EC=1.13.11.20 {ECO:0000256|ARBA:ARBA00013133};
GN   ORFNames=J5N97_008010 {ECO:0000313|EMBL:KAJ0989654.1};
OS   Dioscorea zingiberensis.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Dioscoreales; Dioscoreaceae;
OC   Dioscorea.
OX   NCBI_TaxID=325984 {ECO:0000313|EMBL:KAJ0989654.1, ECO:0000313|Proteomes:UP001085076};
RN   [1] {ECO:0000313|EMBL:KAJ0989654.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Dzin_1.0 {ECO:0000313|EMBL:KAJ0989654.1};
RC   TISSUE=Leaf {ECO:0000313|EMBL:KAJ0989654.1};
RA   Li Z., Yang C.;
RL   Submitted (MAR-2021) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KAJ0989654.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Dzin_1.0 {ECO:0000313|EMBL:KAJ0989654.1};
RX   PubMed=36204203;
RA   Li Y., Tan C., Li Z., Guo J., Li S., Chen X., Wang C., Dai X., Yang H.,
RA   Song W., Hou L., Xu J., Tong Z., Xu A., Yuan X., Wang W., Yang Q., Chen L.,
RA   Sun Z., Wang K., Pan B., Chen J., Bao Y., Liu F., Qi X., Gang D.R., Wen J.,
RA   Li J.;
RT   "The genome of Dioscorea zingiberensis sheds light on the biosynthesis,
RT   origin and evolution of the medicinally important diosgenin saponins.";
RL   Hortic Res 9:0-0(2022).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-cysteine + O2 = 3-sulfino-L-alanine + H(+);
CC         Xref=Rhea:RHEA:20441, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:35235, ChEBI:CHEBI:61085; EC=1.13.11.20;
CC         Evidence={ECO:0000256|ARBA:ARBA00024284};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20442;
CC         Evidence={ECO:0000256|ARBA:ARBA00024284};
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|ARBA:ARBA00001954};
CC   -!- SIMILARITY: Belongs to the cysteine dioxygenase family.
CC       {ECO:0000256|ARBA:ARBA00006622}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAJ0989654.1}.
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DR   EMBL; JAGGNH010000001; KAJ0989654.1; -; Genomic_DNA.
DR   OrthoDB; 271433at2759; -.
DR   Proteomes; UP001085076; Miscellaneous, Linkage group lg01.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR   GO; GO:0070483; P:detection of hypoxia; IEA:UniProtKB-ARBA.
DR   InterPro; IPR012864; PCO/ADO.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   PANTHER; PTHR22966; 2-AMINOETHANETHIOL DIOXYGENASE; 1.
DR   PANTHER; PTHR22966:SF29; PLANT CYSTEINE OXIDASE 3; 1.
DR   Pfam; PF07847; PCO_ADO; 1.
DR   SUPFAM; SSF51182; RmlC-like cupins; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP001085076}.
SQ   SEQUENCE   129 AA;  14482 MW;  824FF868F41C5428 CRC64;
     MYVCTLNDRG LCVRLAKLHT DTVLSAPCPT TVLYPKTGGN LHCFTAVTPC AVLDVLAPPY
     SEAAGRICTY YHDYPYSTFS TEKRPDVDEN EDDYAWLQAI ESPDDLYMRR ANAPVLLYRK
     SIAFQAHAQ
//