ID A0A9J5YXS4_SOLCO Unreviewed; 686 AA.
AC A0A9J5YXS4;
DT 28-JUN-2023, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2023, sequence version 1.
DT 18-JUN-2025, entry version 10.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN ORFNames=H5410_026893 {ECO:0000313|EMBL:KAG5605401.1};
OS Solanum commersonii (Commerson's wild potato) (Commerson's nightshade).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4109 {ECO:0000313|EMBL:KAG5605401.1, ECO:0000313|Proteomes:UP000824120};
RN [1] {ECO:0000313|EMBL:KAG5605401.1, ECO:0000313|Proteomes:UP000824120}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LZ3.2 {ECO:0000313|EMBL:KAG5605401.1};
RC TISSUE=Leaf {ECO:0000313|EMBL:KAG5605401.1};
RA Cho K.;
RT "De no assembly of potato wild relative species, Solanum commersonii.";
RL Submitted (SEP-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00358}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG5605401.1}.
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DR EMBL; JACXVP010000005; KAG5605401.1; -; Genomic_DNA.
DR OrthoDB; 2270193at2759; -.
DR Proteomes; UP000824120; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0044027; P:negative regulation of gene expression via chromosomal CpG island methylation; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:TreeGrafter.
DR CDD; cd23138; RING-HC_ORTHRUS_rpt1; 1.
DR FunFam; 2.30.280.10:FF:000002; E3 ubiquitin-protein ligase ORTHRUS 2; 1.
DR FunFam; 3.30.40.10:FF:000472; E3 ubiquitin-protein ligase ORTHRUS 2; 1.
DR Gene3D; 2.30.280.10; SRA-YDG; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 3.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR047498; RING-HC_ORTHRUS_rpt1.
DR InterPro; IPR036987; SRA-YDG_sf.
DR InterPro; IPR003105; SRA_YDG.
DR InterPro; IPR045134; UHRF1/2-like.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR14140; E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED; 1.
DR PANTHER; PTHR14140:SF27; OS04G0289800 PROTEIN; 1.
DR Pfam; PF02182; SAD_SRA; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00184; RING; 3.
DR SMART; SM00466; SRA; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF88697; PUA domain-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR PROSITE; PS51015; YDG; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 2.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00358}; Reference proteome {ECO:0000313|Proteomes:UP000824120};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 12..63
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 143..182
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 271..419
FT /note="YDG"
FT /evidence="ECO:0000259|PROSITE:PS51015"
FT DOMAIN 514..571
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 101..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 624..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..686
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 686 AA; 76039 MW; 641AE51D8C84864B CRC64;
MAHDSDLPCD GDGVCMACKV KPSENESLTC KTCATPWHVS CLSAPPDSMG DAVNWECPDC
SMPPAADVVP VKHNAAASSS SGGRGDLIAA IRVIESDSTL TEQEKAQKRQ DLMSGNSKDE
DATVEGVNQD KDVLNILDAS LNCSMCMQLP ERPVTTPCGH NFCLKCFQKW VGQRKSTCAN
CRTPIPAKMA SQPRINSALV IAIRMARMMR SGASSGSSKV SHFVHNQNRP DKAFTTERAK
KTGKANACSG KIFVTIPGDH FGPISADNDP ERNVGVMVGE TWEDRFECRQ WGAHFPHVAG
IAGQSDYGAQ SVALSGGYED DEDHGEWFLY TGSGGRDLSG NKRTNKLQSF DQKFEKLNEA
LRVSCLKGYP VRVVRSHKEK RSSYAPDKGV RYDGVYRIEK CWRKPGKQGF KVCRYLFVRC
DNDPAPWTSD EHGDRPRALP AIKELEGATD MTERKGAPAW DYDEEKSCWM WKKAPPPSRK
PVQCENEDGT KVRQVRPKRS TMSVKQRLLK EFTCHLCREV MNHPLTTPCA HNFCKACLDG
AFAGQSFTRQ RTCEGRRTLR AQKNIMKCPS CPTDISDFLQ NPQINRELMN VIESLKRQIE
EENAALSVDV DDGSLDGNNE IIADEAVETD KSVEDDKEGA QPVNEAETKQ THKRKRSSSI
DNVSPKKPVD KSDVVHNLEE VDTAHT
//
