ID A0A9J6C1K6_POLVA Unreviewed; 551 AA.
AC A0A9J6C1K6;
DT 28-JUN-2023, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2023, sequence version 1.
DT 28-JAN-2026, entry version 13.
DE RecName: Full=Ras-related protein Rab-14 {ECO:0000256|ARBA:ARBA00014884};
DE EC=3.6.5.2 {ECO:0000256|ARBA:ARBA00011984};
GN ORFNames=PVAND_005906 {ECO:0000313|EMBL:KAG5676052.1};
OS Polypedilum vanderplanki (Sleeping chironomid midge).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Chironomoidea; Chironomidae;
OC Chironominae; Polypedilum; Polypedilum.
OX NCBI_TaxID=319348 {ECO:0000313|EMBL:KAG5676052.1, ECO:0000313|Proteomes:UP001107558};
RN [1] {ECO:0000313|EMBL:KAG5676052.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NIAS01 {ECO:0000313|EMBL:KAG5676052.1};
RC TISSUE=Whole body or cell culture {ECO:0000313|EMBL:KAG5676052.1};
RA Yoshida Y., Kikawada T., Gusev O.;
RT "Chromosome level genome of the anhydrobiotic midge Polypedilum
RT vanderplanki.";
RL Submitted (MAR-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + phosphate + H(+); Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC Evidence={ECO:0000256|ARBA:ARBA00047660};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00047660};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle
CC {ECO:0000256|ARBA:ARBA00004541}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004438}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004438}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004438}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000256|ARBA:ARBA00004387}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004387}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004387}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Recycling endosome
CC {ECO:0000256|ARBA:ARBA00004172}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000256|ARBA:ARBA00006270}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAG5676052.1}.
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DR EMBL; JADBJN010000002; KAG5676052.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A9J6C1K6; -.
DR OrthoDB; 6285520at2759; -.
DR Proteomes; UP001107558; Chromosome 2.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045335; C:phagocytic vesicle; IEA:InterPro.
DR GO; GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:InterPro.
DR GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0042742; P:defense response to bacterium; IEA:InterPro.
DR GO; GO:0032456; P:endocytic recycling; IEA:InterPro.
DR GO; GO:0006895; P:Golgi to endosome transport; IEA:InterPro.
DR GO; GO:0090382; P:phagosome maturation; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd10431; GHITM; 1.
DR CDD; cd04122; Rab14; 1.
DR FunFam; 3.40.50.300:FF:000344; Ras-related protein Rab-14; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR006214; Bax_inhibitor_1-related.
DR InterPro; IPR035871; GHITM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR030702; Rab14.
DR InterPro; IPR050209; Rab_GTPases_membrane_traffic.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR001806; Small_GTPase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR47979; DRAB11-RELATED; 1.
DR Pfam; PF01027; Bax1-I; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00177; ARF; 1.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00176; RAN; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
DR PROSITE; PS51420; RHO; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Prenylation {ECO:0000256|ARBA:ARBA00023289};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP001107558};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 116..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 521..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 551 AA; 59923 MW; 79BE7A1E024D7419 CRC64;
MLSRLACTRA VINPVLLKSA IQNVPKQRQV FRQFAEDVKF RTRSERINER MSLKERAMAP
AGPNAYAIGK GALAGGSLLG LGALCYYGLG LGSGTNALQN SMLWPQYVRD RIHDTYLYFG
GSILISAASA AAVFRTPALL RLVSGGGWLS IIGTFAVMIG SGMVAQSIPY SPGFGAKQLA
WMAHSAILGG VVAPLCFVGG PIMIRAAWYT AGIVAGLSTV AVCAPSEKFL NMAGPLSIGL
GVVFASSIGS MFLSPATALG ASLYSMSLYG GLLLFSGFLL YDTQKIIRRA ETHPPFGFAP
YDPINNSISI YLDTLNIFIR IVTLLAGGDV KKFSMMTSAP YSYSYIFKYI IIGDMGVGKS
CLLHQFTEKK FMASCPHTIG VEFGTRIIEV DKQKIKLQIW DTAGQERFRA VTRSYYRGAA
GCLMVYDITR RSTYNHLSSW LTDTKNLTNP STVIFLIGNK SDLESTREVT YEEAKKFADE
NGLMFAETSA MSGQNVEEAF LETARKIYQS VQDGRLDLNS AESGVQQKTQ QRPGRTSLTD
DTQTNKDNCS C
//
