ID A0A9J6GCR2_HAELO Unreviewed; 1214 AA.
AC A0A9J6GCR2;
DT 28-JUN-2023, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2023, sequence version 1.
DT 28-JAN-2026, entry version 13.
DE RecName: Full=YTH domain-containing protein {ECO:0000259|PROSITE:PS50882};
GN ORFNames=HPB48_005014 {ECO:0000313|EMBL:KAH9373269.1};
OS Haemaphysalis longicornis (Bush tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Haemaphysalinae;
OC Haemaphysalis.
OX NCBI_TaxID=44386 {ECO:0000313|EMBL:KAH9373269.1, ECO:0000313|Proteomes:UP000821853};
RN [1] {ECO:0000313|EMBL:KAH9373269.1, ECO:0000313|Proteomes:UP000821853}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HaeL-2018 {ECO:0000313|EMBL:KAH9373269.1};
RX PubMed=32814014;
RG Tick Genome and Microbiome Consortium (TIGMIC);
RA Jia N., Wang J., Shi W., Du L., Sun Y., Zhan W., Jiang J.F., Wang Q.,
RA Zhang B., Ji P., Bell-Sakyi L., Cui X.M., Yuan T.T., Jiang B.G., Yang W.F.,
RA Lam T.T., Chang Q.C., Ding S.J., Wang X.J., Zhu J.G., Ruan X.D., Zhao L.,
RA Wei J.T., Ye R.Z., Que T.C., Du C.H., Zhou Y.H., Cheng J.X., Dai P.F.,
RA Guo W.B., Han X.H., Huang E.J., Li L.F., Wei W., Gao Y.C., Liu J.Z.,
RA Shao H.Z., Wang X., Wang C.C., Yang T.C., Huo Q.B., Li W., Chen H.Y.,
RA Chen S.E., Zhou L.G., Ni X.B., Tian J.H., Sheng Y., Liu T., Pan Y.S.,
RA Xia L.Y., Li J., Zhao F., Cao W.C.;
RT "Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic
RT Diversity and Vector Capacities.";
RL Cell 182:1328-1340(2020).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. RNA-
CC metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
CC {ECO:0000256|ARBA:ARBA00006861}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAH9373269.1}.
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DR EMBL; JABSTR010000006; KAH9373269.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A9J6GCR2; -.
DR VEuPathDB; VectorBase:HLOH_052878; -.
DR OrthoDB; 5600060at2759; -.
DR Proteomes; UP000821853; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0032039; C:integrator complex; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0034472; P:snRNA 3'-end processing; IEA:TreeGrafter.
DR CDD; cd21134; YTH; 1.
DR FunFam; 3.10.590.10:FF:000001; YTH domain family 1, isoform CRA_a; 1.
DR Gene3D; 3.40.50.10890; -; 1.
DR Gene3D; 3.10.590.10; ph1033 like domains; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR022712; Beta_Casp.
DR InterPro; IPR027074; Integrator_9su.
DR InterPro; IPR048660; IntS9-like_C.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR InterPro; IPR007275; YTH_domain.
DR PANTHER; PTHR46094; INTEGRATOR COMPLEX SUBUNIT 9; 1.
DR PANTHER; PTHR46094:SF1; INTEGRATOR COMPLEX SUBUNIT 9; 1.
DR Pfam; PF21382; IntS9_C; 1.
DR Pfam; PF16661; Lactamase_B_6; 1.
DR Pfam; PF04146; YTH; 1.
DR SMART; SM01027; Beta-Casp; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
DR PROSITE; PS50882; YTH; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000821853};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 864..996
FT /note="YTH"
FT /evidence="ECO:0000259|PROSITE:PS50882"
FT REGION 577..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 780..840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1102..1122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..598
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 781..799
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1214 AA; 132549 MW; 821DE2BAA187E1CA CRC64;
MLSSRCSSTR LSNLPLWSPR EAGDAQLEGE FKEANGRVFV DSAPEFCLPE TGLVDFADVD
VILISNYQSM LALPYVTERT GFKGTVYMTE PTLLIGRQFM EELVTYIERT PKPRTATKWK
QQAFKFAQLP SLDFGKPRSW RQLYNMQDIN SSLSKVKVVG FAEKVDVFGM VQVSAVSSGY
CLGSCNWMVT ADHEKIVYMS GSSTLTTHPK PIEHSPLRNA DALILTSLTQ TPLANPDTML
GEFCITVAMT VKMGGNVLIP CYPSGVTYDL FECLSGHLET TGQVNVPMLS SAKQAKVYIP
EEPFPHAQLV RGGRLKPFSS IKAEGFAADF HTPCIVFAGH PSLRFGDVVH FMELWGPSPN
NVVIFTEPDF NLAEAIAPFQ PMAMKALCFP IDTSLSFVQA NKLIRDLKPT NLVLPLQYTL
PPLLQPHRTD LVIETECEVQ TYTRGSIVNI PVQRKYQRID MSAELAASMV PVEVKSGLGV
ATLTGILQVN NNRCTLKPVQ KDVSGNKKWN GQTPPKIYTW GSLDVTEFAR KLDKAGFTDV
KVENTASGMI VHLVSTAVSH YPVSNGPKDM VKDEEFDSWR NQNQQPQPAA QQQQQQQQTT
YQPHLSTSNL GEPYIPSYYA SMSFPYLNQG LGDGAWSNGG DPVGFFGSYG GQMGAAGEQP
PQHYVDGGAG MFSQNSFAGY GQGFGFFPGS GGDYSTWGTA ASSGQPAAAA AAAAANKGYP
EEYYRGDYDQ SGMDRGLKHL EQGLRSLALG GDKDFAAAKE PYAKDPKKLA GGDKKLSWAS
VASQPAKPKA VKSKSPLLPA ASKHPMDIGT WEGKNGAKPR GNAAPWASQA PPPPESGFSH
PVLEKLRLEN NYNPKEFDLE PKGARFFIIK SYSEDDIHRS IKYSIWCSTE HGNKRLDAAY
RDAQGPVLLF FSVNGSGHFC GMAEMVSPVD YAASSSVWAQ DKWKGQFRVR WVYVKDVPNS
QLRHIRLENN ENKPVTNSRD TQEVPPDKGR QVLKILHGFR HTTSIFDDFL HYEKRQEEDE
QREFPSVPAG PAEPGLLPNL EHLKAAEAMK DNKRACSVCL SHVADADADE QPPHAVQVPP
SAGVVSTASS LTYSGHANTL AVRPGGALPS PRRKTPVATE SPFDDWTALP RCSPAVRLGP
HRGGLCGSAV CVRVRMCAPC APRSGDKEHG HPTFSPVKPR AAFALPSTVA FPRSAAAAAA
QLPTNRRGDV SFVL
//
