ID A0A9J7HLN0_BRAFL Unreviewed; 336 AA.
AC A0A9J7HLN0;
DT 28-JUN-2023, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2023, sequence version 1.
DT 18-JUN-2025, entry version 12.
DE RecName: Full=E3 ubiquitin-protein ligase NRDP1 {ECO:0000256|ARBA:ARBA00015711};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
DE AltName: Full=RING finger protein 41 {ECO:0000256|ARBA:ARBA00030556};
DE AltName: Full=RING-type E3 ubiquitin transferase NRDP1 {ECO:0000256|ARBA:ARBA00031762};
GN Name=LOC118405251 {ECO:0000313|RefSeq:XP_035660540.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739 {ECO:0000313|Proteomes:UP000001554, ECO:0000313|RefSeq:XP_035660540.1};
RN [1] {ECO:0000313|Proteomes:UP000001554}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|Proteomes:UP000001554};
RX PubMed=32313176;
RA Simakov O., Marletaz F., Yue J.X., O'Connell B., Jenkins J., Brandt A.,
RA Calef R., Tung C.H., Huang T.K., Schmutz J., Satoh N., Yu J.K.,
RA Putnam N.H., Green R.E., Rokhsar D.S.;
RT "Deeply conserved synteny resolves early events in vertebrate evolution.";
RL Nat. Ecol. Evol. 0:0-0(2020).
RN [2] {ECO:0000313|RefSeq:XP_035660540.1}
RP IDENTIFICATION.
RC STRAIN=S238N-H82 {ECO:0000313|RefSeq:XP_035660540.1};
RC TISSUE=Testes {ECO:0000313|RefSeq:XP_035660540.1};
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_035660540.1; XM_035804647.1.
DR GeneID; 118405251; -.
DR KEGG; bfo:118405251; -.
DR OMA; QYENYVC; -.
DR OrthoDB; 1630758at2759; -.
DR Proteomes; UP000001554; Chromosome 18.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0035591; F:signaling adaptor activity; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR GO; GO:0043122; P:regulation of canonical NF-kappaB signal transduction; IBA:GO_Central.
DR CDD; cd16634; mRING-HC-C3HC3D_Nrdp1; 1.
DR FunFam; 3.30.40.10:FF:000268; E3 ubiquitin-protein ligase NRDP1; 1.
DR FunFam; 3.30.40.10:FF:000302; E3 ubiquitin-protein ligase NRDP1; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR015036; NRDP1.
DR InterPro; IPR037255; NRDP1_C.
DR InterPro; IPR003613; Ubox_domain.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR10131:SF157; RECEPTOR-ASSOCIATED FACTOR, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR Pfam; PF08941; USP8_interact; 1.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00504; Ubox; 1.
DR SUPFAM; SSF160088; NRDP1 C-terminal domain-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001554};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 18..57
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT COILED 142..176
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 336 AA; 38164 MW; 9B3DD2300FB62E65 CRC64;
MGYDVNRFEG NVDEELLCPI CGGVLEEPVQ APQCEHAFCT ACIQEWLSRQ HTCPVDRQTI
TPSQLKPVPR ILRNLLSRLY IKCDNANFGC SQVIKLDQLA SHLDECEHNP KRPVSCEQGC
GLVIPKDELK DHNCVRELRT VVSQQQVKLS EFQSELAEQK RMIQDQKREI QMLKEYMRAI
RASNQPLTRA IEDQMESDEV GAVPPLVGRR CLSQEVLRWV RSLQTARVTR WGGMISTPDA
VLQAVIKRSL LDSGCPAGIV DVLMENAHER NWPRGLSTLE TRQMNRRCYE NYVTKRIPGK
QAVVVMACEN QHMGPDMVLE PGLVMIFAHG IDVTDY
//
