ID A0A9J7HNE0_BRAFL Unreviewed; 926 AA.
AC A0A9J7HNE0;
DT 28-JUN-2023, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2023, sequence version 1.
DT 18-JUN-2025, entry version 12.
DE SubName: Full=Dynein heavy chain 3, axonemal-like {ECO:0000313|RefSeq:XP_035662598.1};
GN Name=LOC118406583 {ECO:0000313|RefSeq:XP_035662598.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739 {ECO:0000313|Proteomes:UP000001554, ECO:0000313|RefSeq:XP_035662598.1};
RN [1] {ECO:0000313|RefSeq:XP_035662598.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27412606;
RA Yue J.X., Kozmikova I., Ono H., Nossa C.W., Kozmik Z., Putnam N.H.,
RA Yu J.K., Holland L.Z.;
RT "Conserved non-coding elements in the most distant genera of
RT cephalochordates: the Goldilocks principle.";
RL Genome Biol. Evol. 0:0-0(2016).
RN [2] {ECO:0000313|Proteomes:UP000001554}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|Proteomes:UP000001554};
RX PubMed=32313176;
RA Simakov O., Marletaz F., Yue J.X., O'Connell B., Jenkins J., Brandt A.,
RA Calef R., Tung C.H., Huang T.K., Schmutz J., Satoh N., Yu J.K.,
RA Putnam N.H., Green R.E., Rokhsar D.S.;
RT "Deeply conserved synteny resolves early events in vertebrate evolution.";
RL Nat. Ecol. Evol. 0:0-0(2020).
RN [3] {ECO:0000313|RefSeq:XP_035662598.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000256|ARBA:ARBA00004430}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_035662598.1; XM_035806705.1.
DR GeneID; 118406583; -.
DR KEGG; bfo:118406583; -.
DR OMA; ELFIHVR; -.
DR OrthoDB; 10251809at2759; -.
DR Proteomes; UP000001554; Chromosome 19.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR FunFam; 1.10.8.1220:FF:000001; Dynein axonemal heavy chain 5; 1.
DR FunFam; 1.10.8.720:FF:000001; dynein heavy chain 7, axonemal; 1.
DR FunFam; 1.20.1270.280:FF:000001; dynein heavy chain 7, axonemal; 1.
DR FunFam; 3.10.490.20:FF:000001; dynein heavy chain 7, axonemal; 1.
DR FunFam; 3.40.50.300:FF:000362; Dynein, axonemal, heavy chain 6; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22878; DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED; 1.
DR PANTHER; PTHR22878:SF71; DYNEIN, AXONEMAL, HEAVY CHAIN 3; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001554}.
FT DOMAIN 1..79
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 326..441
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 476..615
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 621..922
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
SQ SEQUENCE 926 AA; 104998 MW; 3F983207F72493FD CRC64;
MITPEGLEDQ LLGIVAAKEK PKLEEEKSEL ILEGARNKKL LKEIEDKILE VLATSQGNIL
EDETAIEILS SSKTLSQEIS EKQEVASRTE REIDDTRNGY KPVAKHSSVL FFAISDLANI
EPMYQYSLTW FINLYLQSII NSDPSPVLED RITNLNNHFT YSIYQNVCRS LFEKDKLLFS
FLLSIGLARM VEGAVDEDEW RFLLTGGVAL DNPYPNPAPD WLKDKSWNEI VRCSDLTAFQ
GFMQHFKSNL GSWKSIYDSN CPHEEELPEP WNSKLSFLEK AIVLRCIRPD KVVPVVQKFI
VTRMGQAYVE PPTFDLSLSY ADSSHFSPLI FVLSPGADPM AGLVKFAEEK GMGGSSLQTI
SLGQGQGPIA EKMIEKAVAE GTWVVLQNCH LAVSWLPELE RICEEVITDP EKTKPEFRLW
LTSYPSPAFP VSALQNGVKM TNEPPKGLKA NLLRSYLNDP ISDPDFFNGC NKPKHWQKLL
FGLCFFHALV QERRNFGPLG WNIPYEFNES DLRISVKQLQ MFLNDYDKVP LDALTYLTGE
CNYGGRVTDE RDRRLLTSIL AIFYCPQITQ DDEYKLSPSG LYYAPQQGSY DSFVEYVRAL
PWTPHPEVFG LHENADISKE QQETQQLLDG ILLTQPRQAA GGGKSAEDLI LELASDILSK
IPPNFNLEQV QTKYPVRYEE SMNTVLVQEL IRFNRLITVI RTSLQDIRKA TNGLVVMSSE
LEDVFDSMMV GKIPAMWAAK SYPSLKPLGS YIADLIARLQ FFQVWIDGGP PHVFWLSGFY
FTHSFMTGAI QNYARKYKIP IDHLAFEFFV QKEEKKMPGK PTDGVYVRGL FLEGARWDRQ
KGLLAESLPK ILYDTLPVIW LKPGKISEIT EKATYECPVY KTSARRGVLS TTGHSTNYVL
SIQLPTDQPQ DHWIIRGVAG LCQLND
//
