ID A0A9J7KW80_BRAFL Unreviewed; 2315 AA.
AC A0A9J7KW80;
DT 28-JUN-2023, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2023, sequence version 1.
DT 18-JUN-2025, entry version 12.
DE SubName: Full=Dynein heavy chain 6, axonemal-like {ECO:0000313|RefSeq:XP_035670913.1};
GN Name=LOC118412272 {ECO:0000313|RefSeq:XP_035670913.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739 {ECO:0000313|Proteomes:UP000001554, ECO:0000313|RefSeq:XP_035670913.1};
RN [1] {ECO:0000313|RefSeq:XP_035670913.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27412606;
RA Yue J.X., Kozmikova I., Ono H., Nossa C.W., Kozmik Z., Putnam N.H.,
RA Yu J.K., Holland L.Z.;
RT "Conserved non-coding elements in the most distant genera of
RT cephalochordates: the Goldilocks principle.";
RL Genome Biol. Evol. 0:0-0(2016).
RN [2] {ECO:0000313|Proteomes:UP000001554}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|Proteomes:UP000001554};
RX PubMed=32313176;
RA Simakov O., Marletaz F., Yue J.X., O'Connell B., Jenkins J., Brandt A.,
RA Calef R., Tung C.H., Huang T.K., Schmutz J., Satoh N., Yu J.K.,
RA Putnam N.H., Green R.E., Rokhsar D.S.;
RT "Deeply conserved synteny resolves early events in vertebrate evolution.";
RL Nat. Ecol. Evol. 0:0-0(2020).
RN [3] {ECO:0000313|RefSeq:XP_035670913.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000256|ARBA:ARBA00004430}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_035670913.1; XM_035815020.1.
DR GeneID; 118412272; -.
DR KEGG; bfo:118412272; -.
DR OMA; QHKLVYS; -.
DR OrthoDB; 5593012at2759; -.
DR Proteomes; UP000001554; Chromosome 3.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR FunFam; 1.10.8.1220:FF:000001; Dynein axonemal heavy chain 5; 1.
DR FunFam; 1.10.8.720:FF:000007; Dynein axonemal heavy chain 6; 1.
DR FunFam; 3.10.490.20:FF:000005; Dynein axonemal heavy chain 6; 1.
DR FunFam; 3.40.50.300:FF:002141; Dynein heavy chain; 1.
DR FunFam; 3.40.50.300:FF:000223; Dynein heavy chain 3, axonemal; 1.
DR FunFam; 1.10.472.130:FF:000015; Dynein heavy chain 7; 1.
DR FunFam; 1.20.920.30:FF:000005; Dynein, axonemal, heavy chain 2; 1.
DR FunFam; 1.20.1270.280:FF:000009; Dynein, axonemal, heavy chain 6; 1.
DR FunFam; 1.20.920.20:FF:000006; Dynein, axonemal, heavy chain 6; 1.
DR FunFam; 3.40.50.300:FF:000362; Dynein, axonemal, heavy chain 6; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22878:SF68; DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE; 1.
DR PANTHER; PTHR22878; DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0000256|ARBA:ARBA00047216};
KW Reference proteome {ECO:0000313|Proteomes:UP000001554}.
FT DOMAIN 81..203
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 422..511
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 569..828
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 842..1172
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 1201..1421
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 1695..1810
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 1842..1979
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 1986..2311
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 1613..1634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1057..1098
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2315 AA; 263953 MW; 9DBD6E18B25F9E0E CRC64;
MNTVLDDNKM LCLANSERIK LSPWIHMVFE VQDLAVASPA TVSRCGMVYV DPDELRWRPY
VQKWMAERGA KFKEETQAYI MDLFDQYVEK GLQFVNKKCV QAINQVDISK VNTLCCLLES
LLLVGKEVDL KQDPTKLHPL ICTVFVFCYL WSVGGNLLEQ YFDAFETFVR QQMEDNPDAK
LYAGGDLWSC FIDFDSKRMD IWEKRVPVFN YSAEVPFFDI LVPTIDTVRF GYLLEKLLDV
GRSVLYTGTT GVGKSVIARA ILNDLAEPKS YVPVTINFSA QTSSKRTQEI VEGKLEKKRK
NILGAPINKK VVIFIDDLNM PKLDTYGSQP PIELLRQYQD FGGFYDREKL FWKEIKDVTL
CAACAPPGGG RNPVTPRLIR HFSMLCLPSP SEHSLKHIFK AILSGFLKDF PAPVKQSVES
VVSAAVEIYE RLSTDLLPTP AKSHYVFNLR DLSKCIQGIL QSDASTIREQ LHIFRLFCHE
CQRVFHDRLI NEEDKLFFNT ILSEMSSKHF GQNVEPETFV NNPIIFGDFI KMGAPKNDRQ
YEELSDMKKL KNVLSDYLDD YNMSSSKEMK LVFFVDAIQH VSRIVRMIRQ ERGNALLVGV
GGTGKQSLTR LACHICGYNC FQIELSRGYN YDAFHEDLKK LYDMAGLKGE NTVFLFTDTQ
IVVEEFLEDI NNILNSGEVP NLFEADEYEK VMAGTRPKAK EAGIAEGDRD AIFNFFIGQV
RNNLHIVLCM SPVGDAFRSR CRMFPSLVNC CTIDWFVQWP REALLSVSQT FFEQVDLGSD
EMKEKISEMC MEIHVSVTDM SERFYAELRR RYYTTPTSYL ELINLYLSML GEKKKQLVSA
RDRVKNGLEK ILETNVLVAN MEQELTLLEP ELKQKSEDTD ALMEKLVVDQ EKADQVRRVV
QEDEAVARVK AEETQAIADD AQKDLDEALP ALDAAQKALD ALDKSDISEL KVFNKPPDMV
MTVMEAICIL LKSKTDWPSA KSLLGDPNFL KRLLDYDKDN IPNALLTKLK KYIDNPNFVP
EIVEKTSKAC RSMCMWVRAM DLYARIFRQV EPKKERLHAA QAELDATMAT LAEKQAKLKE
VEDQIAELQA LYDHSVAEKD RLVKQMSLTQ ARLKRAGKLT TALADEQDRW TVNVAEFERD
LGNVVGNVFV AAACVAYYGA FTSIYRLQLV DHWAQRCQEL EIPVSQNLSL SSVMADPYEI
RQWNVDGLPR DNVSIENAIM VTRGRRWPLM IDPQEQANRW VRNKEARNGL KVIKLTDKDF
LRTLENAIRL GMPVLLEELG EMLDPALEPI LLKQTFVQGG RLLIRLGDSD VDYDKNFKFY
MTTKMANPHY LPEVCIKVTI INFTVTKSGL EDQLLGDVTS LERPDLEEQR NQLIVRINAD
KNQLKAIEDR ILKLLFHSQG NILDDEELIN TLNESKVTSG VINTRLSEAE ETEAKITTAR
EKYRPVSARG STMYFVVASL AEIDPMYQFS LKYFKQLFNM TIEQSEKSDD LSVRLTTLLD
QTTIAIYTNV SRGLFEVHKL VFSFMLCAEI MRQEGTINDV EWNFFLRGAG SMDRQRPEKP
EADWLTSHVW NTCYDMHDLV PAFHGLTTDI MQTPIWVKIG RLEVRLNPNE WDGYGPEPPA
YTPPEEGQEA AKDDGKVKGH WNERLTSFQK VIMVKCFMEE KVVFAVTDFV TENLGKQFVE
SPPIDLATLY QDTTPSVPLI FILSTGSDPM SNFQRFARER GFLSRIQAIS LGQGQGPVAE
ALIAKGTEQG DWVFLQNCHL AQSWMLRMEE TIKDMQENVD KLHPDFRLYL SSMPAGHFPV
SVLQNSVKVT NEPPKGLRAN MRRAFTEITP SFFEENILGQ QWRKAIFGLC FFHATILERK
KFGPLGWNIK YEFSDSDREC ALLNLQMFCA EGSIPWDALF YITKEITYGG RVTDIWDQRC
LGTVLQRFFS AKTLDQDYKY STSGIYYAPE TETLASYRQY VEDLPILDDP EIFCMHDNAN
ISFQVQETTA LVSTVLEVQP RSTGGGGGKS DDDTVYELAE TILGKLPDSL DVENADSSMF
EPDSKGRLNS LTTVLVQEVD RFNSLLKVIK NSLKQLQKAI KGLVVMSEQL EMVYVAFLNN
QVPGLWANSA YPSLKPLASW VQDLIYRTSF IDNWIRQGLP KSYWLSGFFF PQGFLTGTLQ
NYARRYDYPI DALSFQFKVI PHYRAQADVY EAQKNLQFGE EMELDKEIDS PQDGVLVHGL
FFDCARWDDE NCVVGDALKG TMNAPLPIMH MEPRMNYSPD ATDYPCPLYK TSARAGVLST
TGHSTNFVVP VYLPSSQPAD YWVSMGTALL CQLNE
//
