ID A0A9J7L8A0_BRAFL Unreviewed; 619 AA.
AC A0A9J7L8A0;
DT 28-JUN-2023, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2023, sequence version 1.
DT 18-JUN-2025, entry version 12.
DE SubName: Full=Short transient receptor potential channel 4-like {ECO:0000313|RefSeq:XP_035677174.1};
GN Name=LOC118416200 {ECO:0000313|RefSeq:XP_035677174.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739 {ECO:0000313|Proteomes:UP000001554, ECO:0000313|RefSeq:XP_035677174.1};
RN [1] {ECO:0000313|Proteomes:UP000001554}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|Proteomes:UP000001554};
RX PubMed=32313176;
RA Simakov O., Marletaz F., Yue J.X., O'Connell B., Jenkins J., Brandt A.,
RA Calef R., Tung C.H., Huang T.K., Schmutz J., Satoh N., Yu J.K.,
RA Putnam N.H., Green R.E., Rokhsar D.S.;
RT "Deeply conserved synteny resolves early events in vertebrate evolution.";
RL Nat. Ecol. Evol. 0:0-0(2020).
RN [2] {ECO:0000313|RefSeq:XP_035677174.1}
RP IDENTIFICATION.
RC STRAIN=S238N-H82 {ECO:0000313|RefSeq:XP_035677174.1};
RC TISSUE=Testes {ECO:0000313|RefSeq:XP_035677174.1};
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) = Ca(2+)(out); Xref=Rhea:RHEA:29671,
CC ChEBI:CHEBI:29108; Evidence={ECO:0000256|ARBA:ARBA00036634};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_035677174.1; XM_035821281.1.
DR GeneID; 118416200; -.
DR KEGG; bfo:118416200; -.
DR OMA; VMESHIE; -.
DR OrthoDB; 301415at2759; -.
DR Proteomes; UP000001554; Chromosome 5.
DR GO; GO:0034703; C:cation channel complex; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IBA:GO_Central.
DR GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR GO; GO:0070588; P:calcium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR FunFam; 1.10.287.70:FF:000266; Transient receptor potential cation channel subfamily c member 1; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR002153; TRPC_channel.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR PANTHER; PTHR10117:SF54; TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR SMART; SM01420; TRP_2; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001554};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 177..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 222..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 344..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 387..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 489..509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 1..31
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 24..86
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
FT REGION 570..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 619 AA; 71234 MW; 639F7F0CCE72C61B CRC64;
MTPVMLAAMK NNYDILEMLL QAGFPTLETD AYQWTTSISQ AKAWLDAYRA VCSPSYILLT
SPDPFRTAFR TAKALRDVCW KREQYRPELE QLADQCETFA CELLEEVCTT EELDILGHTD
DPEGMSDESV GTLQLAVDLK QRQFSTQPLC VEYLALSRVK EAFEFHEVFG NWEKMPVVYA
ALWGIAIQLS YPLLCLAYII APDSRIGKFS RLHFIREHSW NMSWFMLMAL LLIETQYYQV
GRVEIDSIVR GTPLLVPYTE VSVAQTLIML WVAGILLEEL QEVQHEGLGR YFRQFWNILD
FTLVALYLAQ MALRLVAYVQ LGVYDQDTVA TQWMIKASPH TFEPVAVADV LFSLFTITVF
MRSLSIFSHY RYLGTLMISI GRMFADIVNF ISMDGVVTFA FACGLNQLYW YYGTVHEYLC
EEYSKGNLKT VDCQRSHGFS TILKTVESLF WATFGITDLS MLELDPDSST LEALRIMEQP
VLTETVGKLI FVLFHATVVL VLLNLLIAIM SDSYQRTQDE KRRDWTFSIV KDMLFYMRVD
LSLAPPFNLL LLVKTSVSRL LCAVCRQGNR RSPHSAIGQG SVHPSSPSKQ ERQEKYKMMI
DRLVNRYLLR KERETENQR
//
