ID A0A9J7LT26_BRAFL Unreviewed; 1056 AA.
AC A0A9J7LT26;
DT 28-JUN-2023, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2023, sequence version 1.
DT 18-JUN-2025, entry version 12.
DE SubName: Full=Receptor-type tyrosine-protein phosphatase N2-like {ECO:0000313|RefSeq:XP_035688113.1};
GN Name=LOC118423909 {ECO:0000313|RefSeq:XP_035688113.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739 {ECO:0000313|Proteomes:UP000001554, ECO:0000313|RefSeq:XP_035688113.1};
RN [1] {ECO:0000313|RefSeq:XP_035688113.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27412606;
RA Yue J.X., Kozmikova I., Ono H., Nossa C.W., Kozmik Z., Putnam N.H.,
RA Yu J.K., Holland L.Z.;
RT "Conserved non-coding elements in the most distant genera of
RT cephalochordates: the Goldilocks principle.";
RL Genome Biol. Evol. 0:0-0(2016).
RN [2] {ECO:0000313|Proteomes:UP000001554}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|Proteomes:UP000001554};
RX PubMed=32313176;
RA Simakov O., Marletaz F., Yue J.X., O'Connell B., Jenkins J., Brandt A.,
RA Calef R., Tung C.H., Huang T.K., Schmutz J., Satoh N., Yu J.K.,
RA Putnam N.H., Green R.E., Rokhsar D.S.;
RT "Deeply conserved synteny resolves early events in vertebrate evolution.";
RL Nat. Ecol. Evol. 0:0-0(2020).
RN [3] {ECO:0000313|RefSeq:XP_035688113.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004212}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004212}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
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DR RefSeq; XP_035688113.1; XM_035832220.1.
DR GeneID; 118423909; -.
DR KEGG; bfo:118423909; -.
DR OrthoDB; 9880441at2759; -.
DR Proteomes; UP000001554; Chromosome 10.
DR GO; GO:0030141; C:secretory granule; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0051046; P:regulation of secretion; IBA:GO_Central.
DR FunFam; 3.90.190.10:FF:000017; receptor-type tyrosine-protein phosphatase-like N isoform X2; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.30.70.2470; Protein-tyrosine phosphatase receptor IA-2 ectodomain; 1.
DR InterPro; IPR033522; IA-2/IA-2_beta.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR021613; Receptor_IA-2_dom.
DR InterPro; IPR038112; Receptor_IA-2_ectodomain_sf.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46106; IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C; 1.
DR PANTHER; PTHR46106:SF4; IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C; 1.
DR Pfam; PF11548; Receptor_IA-2; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001554};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1056
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5039911613"
FT TRANSMEM 660..683
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 786..1046
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 965..1037
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 381..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..433
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..448
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..458
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..508
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..762
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1056 AA; 117820 MW; 1E7858D480122B72 CRC64;
MLLPRILAIL GVIVCVCGGG RAERGERVYG CLFQKDLCRR DEICVVDNLF GSCQEDPVEA
IYSYNPSSQQ LKDLRDDITE LVTDGYGWRE DITQATIGGH LNRIHQDYVA EPPGNQEGYD
SLGKADPYLG QLYPGAAQLS TGVEKRRQEM VDQLNKQYLD LMDRERALEQ QAVEERHMKE
ALQWQAGQQG ILGDDRSEEF VNSWLDDPEI RAKLKTLLNT IVQYYGNDID TPNDDYVKKG
GDGSYYDYEG VNSPNRGEGD GNRLVWGDFG GGGMDEDGVP DEKLVAVPKW QDYFSDADMT
TTATKPLTEA GMVFGGGGDE IESREDPVDD DIIPTPDADM LLSLVGKELN SLLDGTIRLE
DLTDEEYKLL AQAVRETISL LQDDKEQDGD SGGQEDAIDE ETRDSEGEIE DGTGEAPDGS
EEDTKENPEE TSDPEVTKKD PEEGAVEEKE AEDADSDGQE EKKDEETWIQ EDQGEQKKSP
ASQQSFFRNG PPSLKFKSEE EEKEEKPTID SKAWFIPIED NRGRQVGIFD LKDAMEASVE
RNHAFLVFDR KVTYDDGTKV RDALADIIGV PTEIFSDISV LDNHVSFLVR PNDKGLNAST
VAHLAENNKE ALQKAVGMEL VGTGIGSNEM SHHVEFLLKT KELPLTRIEI VENAEEGPHY
LVLTVIVVGC LAGVLVAVIA IYFMKRSAHR DAKLQGLTGG HPDMDATADY QELCRQRMAS
KATEKPEPMT SQSRFSSLSE ERVRSPSSRS STSSWSEEPV SSNMDISTGH IVLAYMEDHL
KNKDRLEKEW QQLQNYEPDI HSTVIGLSGG NAAKNRVSDA VPYDHSRVIL NDSLNIGTAD
YINASTITDH DPRNHAYIAT QGPLETSVCD FWQMVWEQGS VVIVMLCSLQ EGGSEQCCQY
WPEEGNSLYH IYEVHLVSEH IWCEDFLVRS FYLKNIQTGE TRTVTQFHFL SWPEGGIPAT
PKALLEFRRK VNKCYRGKSC PIVVHCSDGC GRTGTYCLVD MVLNRMTKGA KEIDIAATLE
HIRDQRPNMV KSKDQFEFAL TAVAEEVNAI LKALPQ
//
