ID A0A9J7M1R0_BRAFL Unreviewed; 715 AA.
AC A0A9J7M1R0;
DT 28-JUN-2023, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2023, sequence version 1.
DT 18-JUN-2025, entry version 12.
DE SubName: Full=Fragile X mental retardation syndrome-related protein 1-like {ECO:0000313|RefSeq:XP_035692378.1};
GN Name=LOC118426892 {ECO:0000313|RefSeq:XP_035692378.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739 {ECO:0000313|Proteomes:UP000001554, ECO:0000313|RefSeq:XP_035692378.1};
RN [1] {ECO:0000313|RefSeq:XP_035692378.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27412606;
RA Yue J.X., Kozmikova I., Ono H., Nossa C.W., Kozmik Z., Putnam N.H.,
RA Yu J.K., Holland L.Z.;
RT "Conserved non-coding elements in the most distant genera of
RT cephalochordates: the Goldilocks principle.";
RL Genome Biol. Evol. 0:0-0(2016).
RN [2] {ECO:0000313|Proteomes:UP000001554}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|Proteomes:UP000001554};
RX PubMed=32313176;
RA Simakov O., Marletaz F., Yue J.X., O'Connell B., Jenkins J., Brandt A.,
RA Calef R., Tung C.H., Huang T.K., Schmutz J., Satoh N., Yu J.K.,
RA Putnam N.H., Green R.E., Rokhsar D.S.;
RT "Deeply conserved synteny resolves early events in vertebrate evolution.";
RL Nat. Ecol. Evol. 0:0-0(2020).
RN [3] {ECO:0000313|RefSeq:XP_035692378.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, filopodium tip
CC {ECO:0000256|ARBA:ARBA00004495}. Cell projection, neuron projection
CC {ECO:0000256|ARBA:ARBA00004487}. Cytoplasm, Stress granule
CC {ECO:0000256|ARBA:ARBA00004210}. Perikaryon
CC {ECO:0000256|ARBA:ARBA00004484}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the FMR1 family.
CC {ECO:0000256|ARBA:ARBA00006633}.
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DR RefSeq; XP_035692378.1; XM_035836485.1.
DR GeneID; 118426892; -.
DR KEGG; bfo:118426892; -.
DR OMA; DQQQRGY; -.
DR OrthoDB; 424249at2759; -.
DR Proteomes; UP000001554; Chromosome 12.
DR GO; GO:0010494; C:cytoplasmic stress granule; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR GO; GO:0045182; F:translation regulator activity; IBA:GO_Central.
DR GO; GO:0048513; P:animal organ development; IBA:GO_Central.
DR GO; GO:0051028; P:mRNA transport; IBA:GO_Central.
DR GO; GO:0048170; P:positive regulation of long-term neuronal synaptic plasticity; IBA:GO_Central.
DR GO; GO:0045727; P:positive regulation of translation; IBA:GO_Central.
DR GO; GO:0043488; P:regulation of mRNA stability; IBA:GO_Central.
DR GO; GO:0099577; P:regulation of translation at presynapse, modulating synaptic transmission; IBA:GO_Central.
DR CDD; cd22425; KH_I_FMR1_FXR_rpt1; 1.
DR CDD; cd22427; KH_I_FMR1_FXR_rpt3; 1.
DR CDD; cd20402; Tudor_Agenet_FMRP-like_rpt1; 1.
DR FunFam; 2.30.30.140:FF:000002; Fragile X mental retardation 1, isoform CRA_e; 1.
DR FunFam; 3.30.1370.10:FF:000004; Fragile X mental retardation 1, isoform CRA_e; 1.
DR FunFam; 3.30.1370.10:FF:000054; Fragile X mental retardation protein 1; 1.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR InterPro; IPR008395; Agenet-like_dom.
DR InterPro; IPR040148; FMR1.
DR InterPro; IPR022034; FMR1-like_C_core.
DR InterPro; IPR040472; FMRP_KH0.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR041560; Tudor_FRM1.
DR PANTHER; PTHR10603; FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN; 1.
DR PANTHER; PTHR10603:SF7; FRAGILE X MESSENGER RIBONUCLEOPROTEIN 1 HOMOLOG; 1.
DR Pfam; PF05641; Agenet; 1.
DR Pfam; PF12235; FXMRP1_C_core; 1.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF17904; KH_9; 1.
DR Pfam; PF18336; Tudor_FRX1; 1.
DR SMART; SM00322; KH; 2.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR PROSITE; PS51641; AGENET_LIKE; 2.
DR PROSITE; PS50084; KH_TYPE_1; 2.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000001554};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00117}; Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT DOMAIN 4..50
FT /note="Agenet-like"
FT /evidence="ECO:0000259|PROSITE:PS51641"
FT DOMAIN 63..117
FT /note="Agenet-like"
FT /evidence="ECO:0000259|PROSITE:PS51641"
FT REGION 324..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 199..226
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 411..426
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..496
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..556
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..572
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..593
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..605
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..617
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..651
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..670
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..685
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..715
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 715 AA; 80907 MW; AB05149132810A7E CRC64;
MEDLAVEVCG QNGAFYTACI RDIHEEEVTV AFENDWQPER KVPFQDVRLP SAPVEDYEPQ
EGDEVEVHAA LAETNDEPCG WWPCRVKRCK GAFCVVEYLD LEATFKDIID TGKIRPANKN
PPLTKDSFHK CTIDVPEDLR ECCRVESNHN EFKRALKLTA GSVVFNTDLN AIVVISNDEA
AVKRAQILSD MHFRSLRTKL MLEARKKEAQ QQLETTKAMQ RQCLEEFSVR EDLMGLAIGS
HGANIMQARR LEGVTAIELE EQTCTFKIYG ETKEAVQQAR RMLEYKQDVV QVPRNLIGRV
IGKNGRIIQE IVDKSGVVRV KIEGDNEKEH TVQREEDPSA KDSVPEHVPM IFIGTTEQNS
NAKMLLDYHL AHLKEVEQLR IENLQIAEEL RNAGGGGGTY FPPPRERRYS TDYTSDTTES
TSRGRGQMYG RGRGRGGSRG RGQGGRGRPR RYQGSRNAVS ENDRRHQDEL SDWSSAVTED
SMSEASGVRG SRYSGNRGRG GRRPRINTEP NFDREVRQGD NHNPFDVLNQ DENENGDVNG
RPNQRRNRDR RQNDRRRRND EEDSVLDTEG ETNTERGRGT NVTLYSYIQQ EEANNSRDGN
KDSAGKNRRR RNRRRRERQN TVIFNENAKK ESPEAATGDR AEETSGHETA KSTDTSKMIS
ENEEKPDAPK QQRPSRSKRG PRGNRQRGGS EKSAINGDGG PGIQEHSQQL VNGTA
//
