ID   A0A9J7N8E0_BRAFL        Unreviewed;       286 AA.
AC   A0A9J7N8E0;
DT   28-JUN-2023, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2023, sequence version 1.
DT   18-JUN-2025, entry version 12.
DE   SubName: Full=Short stature homeobox protein 2-like isoform X1 {ECO:0000313|RefSeq:XP_035693605.1};
GN   Name=LOC118427783 {ECO:0000313|RefSeq:XP_035693605.1};
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomatidae; Branchiostoma.
OX   NCBI_TaxID=7739 {ECO:0000313|Proteomes:UP000001554, ECO:0000313|RefSeq:XP_035693605.1};
RN   [1] {ECO:0000313|Proteomes:UP000001554}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 {ECO:0000313|Proteomes:UP000001554};
RX   PubMed=32313176;
RA   Simakov O., Marletaz F., Yue J.X., O'Connell B., Jenkins J., Brandt A.,
RA   Calef R., Tung C.H., Huang T.K., Schmutz J., Satoh N., Yu J.K.,
RA   Putnam N.H., Green R.E., Rokhsar D.S.;
RT   "Deeply conserved synteny resolves early events in vertebrate evolution.";
RL   Nat. Ecol. Evol. 0:0-0(2020).
RN   [2] {ECO:0000313|RefSeq:XP_035693605.1}
RP   IDENTIFICATION.
RC   STRAIN=S238N-H82 {ECO:0000313|RefSeq:XP_035693605.1};
RC   TISSUE=Testes {ECO:0000313|RefSeq:XP_035693605.1};
RG   RefSeq;
RL   Submitted (MAR-2025) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR   RefSeq; XP_035693605.1; XM_035837712.1.
DR   GeneID; 118427783; -.
DR   KEGG; bfo:118427783; -.
DR   OMA; YDCKEKR; -.
DR   OrthoDB; 6159439at2759; -.
DR   Proteomes; UP000001554; Chromosome 12.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   FunFam; 1.10.10.60:FF:000057; Short stature homeobox 2; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR001356; HD.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR009057; Homeodomain-like_sf.
DR   InterPro; IPR000047; HTH_motif.
DR   InterPro; IPR003654; OAR_dom.
DR   InterPro; IPR052631; Paired_homeobox_Bicoid.
DR   PANTHER; PTHR46255:SF3; HOMEOBOX DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR46255; SHORT STATURE HOMEOBOX; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03826; OAR; 1.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS50803; OAR; 1.
PE   4: Predicted;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000001554}.
FT   DOMAIN          102..162
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DOMAIN          268..281
FT                   /note="OAR"
FT                   /evidence="ECO:0000259|PROSITE:PS50803"
FT   DNA_BIND        104..163
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   REGION          1..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..45
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        78..102
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   286 AA;  31552 MW;  2AF15944AA0C0AE7 CRC64;
     MEELTAFVSK SFDGKDKAEE IREERTYKEV LGDLKGDMDQ RHGDSGAESD VDGDDLCPVG
     SPGLPVGLGG GENSPGPENK DPSKPGEKKD DIESPNSKDG KLKQRRSRTN FTLEQLQELE
     RLFDETHYPD AFMREELSQR LGLSEARVQV WFQNRRAKCR KQENQLQKGG DMLCSALRGN
     LTTRVSAHTG MMMGSNLDTC RVAPYMNMGT VRMPFERVQA HLQFDAAAHA PHPSMMLYAP
     APYALPITSM AGSLAAGSLE VTKNSKNNSI ADLRLKARKH AEALGL
//