ID   A0A9J7Y4V2_CYPCA        Unreviewed;       526 AA.
AC   A0A9J7Y4V2;
DT   28-JUN-2023, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2023, sequence version 1.
DT   28-JAN-2026, entry version 13.
DE   SubName: Full=Suppressor of cytokine signaling 5a {ECO:0000313|Ensembl:ENSCCRP00000113798.1};
OS   Cyprinus carpio carpio.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=630221 {ECO:0000313|Ensembl:ENSCCRP00000113798.1, ECO:0000313|Proteomes:UP001108240};
RN   [1] {ECO:0000313|Ensembl:ENSCCRP00000113798.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2025) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
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DR   AlphaFoldDB; A0A9J7Y4V2; -.
DR   Ensembl; ENSCCRT00000125954.1; ENSCCRP00000113798.1; ENSCCRG00000061434.1.
DR   Ensembl; ENSCCRT00000143915.1; ENSCCRP00000166255.1; ENSCCRG00000061434.1.
DR   Ensembl; ENSCCRT00000161119.1; ENSCCRP00000149677.1; ENSCCRG00000061434.1.
DR   Ensembl; ENSCCRT00000164235.1; ENSCCRP00000155700.1; ENSCCRG00000061434.1.
DR   Ensembl; ENSCCRT00000202042.1; ENSCCRP00000169884.1; ENSCCRG00000061434.1.
DR   GeneTree; ENSGT00940000164285; -.
DR   Proteomes; UP001108240; Unplaced.
DR   GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR   GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR   FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR022252; SOCS4/SOCS5_dom.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF12610; SOCS; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF158235; SOCS box-like; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   4: Predicted;
KW   Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Reference proteome {ECO:0000313|Proteomes:UP001108240};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          371..466
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          461..510
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
FT   REGION          99..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          228..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..112
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        228..238
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   526 AA;  58361 MW;  90F63486598143A0 CRC64;
     MEKVGKVWSN LKKGCQSLLH TDGGSRIETP PQLQPQTDTV CQSVNKAQGD NTLEASSPSS
     SVATLPLVAW RTGGSVTRHN CVVDAPQILE ITVEQDTEDA RAPLGARRDS YSRHAPWSGK
     KRHSCSTKAQ SSLETTDRRS GRSRRRHGTG SSREELESGG TRSLRQQIHD TVGLCLPLRS
     SSRNSHLPPP KRKIQITELM LETCPFAPGS DLARKWHLIK QHTAPVTVTP VDSSSDASGA
     TCASPEDEEE RLRERRRLSI EEGVDPPPDA QIHTVEAITA PLASLYKLGP KLAPGMGEAQ
     GDSLGATAAN CDSEDDDTTT LCLQARRPKQ RHGSAEGHLS SKQQGPWKVH TQIDYIHCLV
     PDLLQITALS CYWGVMDRYE AEALLDGRPE GTFLLRDSAQ EDYLFSVSFR RYGRSLHARI
     EQWNHNFSFD AHDPCVFHAA TVTALLEHYK DPSACMFFEP LLTVPLHRTF PFGLQSLARS
     AICNGITYDG IGALPLPPAL QEHLREYHYK QRVRVRWLER EPVKAK
//