ID   A0A9J7YYA2_CYPCA        Unreviewed;       432 AA.
AC   A0A9J7YYA2;
DT   28-JUN-2023, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2023, sequence version 1.
DT   28-JAN-2026, entry version 13.
DE   SubName: Full=Forkhead box P3b {ECO:0000313|Ensembl:ENSCCRP00000124031.1};
OS   Cyprinus carpio carpio.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=630221 {ECO:0000313|Ensembl:ENSCCRP00000124031.1, ECO:0000313|Proteomes:UP001108240};
RN   [1] {ECO:0000313|Ensembl:ENSCCRP00000124031.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSCCRP00000124031.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR   AlphaFoldDB; A0A9J7YYA2; -.
DR   Ensembl; ENSCCRT00000176332.1; ENSCCRP00000124031.1; ENSCCRG00000074175.1.
DR   GeneTree; ENSGT00940000165955; -.
DR   Proteomes; UP001108240; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   CDD; cd20066; FH_FOXP3; 1.
DR   FunFam; 1.10.10.10:FF:000010; Forkhead box P2 isoform B; 1.
DR   Gene3D; 1.20.5.340; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR047413; FH_FOXP3.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR050998; FOXP.
DR   InterPro; IPR032354; FOXP-CC.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR45796; FORKHEAD BOX P, ISOFORM C; 1.
DR   PANTHER; PTHR45796:SF2; FORKHEAD BOX P3; 1.
DR   Pfam; PF00250; Forkhead; 1.
DR   Pfam; PF16159; FOXP-CC; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00089}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP001108240};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          317..403
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000259|PROSITE:PS50039"
FT   DNA_BIND        317..403
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT   REGION          43..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          134..175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        48..73
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        161..175
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   432 AA;  50024 MW;  9ACD0538C888F0F9 CRC64;
     MVFSLKLSFL SYKDPFTLIF NQNSTGRQRL TTKAQVFFRL LTSGMPQSER ESDKRVSGRE
     NERQPPLKEE RDASPPLLNE SSSPQHVEHL SSGRAADEQR MQFLQVVFQN SPAGPIRPSV
     LRSTALLLQA NESHQTTMNR RKDTGPSEAV AGSSQHRKQF PSFQSHSPVE SETQRSSSLF
     VNGQCRWPSC DRVFEGYTHF LRHLNRDHST DEKTIAQWRV QQDLVRHMEN QLIQEKQKLH
     AMQLHLQLFE CVSTRTGAAT GWGRPLALNL PPLGEPDGRT ERASVAPVRQ EPCHIPPPHL
     LPDFVSSVEY YKYANLRPPY TYAFLIRWSI LEAPDKQRTL NEIYNWFTRM FFYFRHNSPT
     WKNAVRHNLS LHKCFVRVDG RTGAVWTVDE EEFQKRKGQK IHRDYTFKWL TPFSYCPSHE
     ASDVSIKATN SQ
//