ID A0A9J8AI02_CYPCA Unreviewed; 3710 AA.
AC A0A9J8AI02;
DT 28-JUN-2023, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2023, sequence version 1.
DT 08-OCT-2025, entry version 12.
DE SubName: Full=Lysosomal trafficking regulator {ECO:0000313|Ensembl:ENSCCRP00000142211.1};
OS Cyprinus carpio carpio.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Cyprininae; Cyprinus.
OX NCBI_TaxID=630221 {ECO:0000313|Ensembl:ENSCCRP00000142211.1, ECO:0000313|Proteomes:UP001108240};
RN [1] {ECO:0000313|Ensembl:ENSCCRP00000142211.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2025) to UniProtKB.
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DR Ensembl; ENSCCRT00000191520.1; ENSCCRP00000142211.1; ENSCCRG00000000945.2.
DR GeneTree; ENSGT00940000156359; -.
DR Proteomes; UP001108240; Unplaced.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR FunFam; 2.130.10.10:FF:000292; Lysosomal trafficking regulator; 1.
DR FunFam; 1.10.1540.10:FF:000001; neurobeachin isoform X1; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR050865; BEACH_Domain.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF86; LYSOSOMAL-TRAFFICKING REGULATOR; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP001108240};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 2918..3024
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 3029..3331
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3521..3555
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 112..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 921..946
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1015..1037
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1050..1076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1161..1223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2014..2077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2099..2138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2475..2494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2582..2606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1026..1037
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1059..1073
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1195..1208
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2015..2031
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2066..2077
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2122..2138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3710 AA; 414499 MW; 48E041E83CD29BFA CRC64;
MSGASNTLAR EFLTDVHQLC SAVAQRAEDE EESHMVALGE YLVRGRGFLL LSTLDFVIDQ
ELTCREELLT LLLSLLPLVW KIPVQEDKAP DFTLPSLLEV FLCQEGRTIP QKAGQDRCDV
QNSGKRLSGS SKSRRSRRTA QRYSVRDARK SQLSTSDSEA NSDDKTTNTG SKHRRFHSSA
VRVSCQLHQS NNPSQPASQH PTLDAMSTIE PSQPHRLFGS HTLDPNMLTD PTTLSIFNRM
ENSPFDLCHV LLSLLEKVCK FDMTINHNPG LAVSVVPTLT EILTEFGDCC GPGGGGRGGI
DELAGGWTEE PVALVQRMLL RTILHLMFVD VGQNETLPDN LRRSLTDLFR ATLKIRTCLE
RQADPFAPRP KKTLQEIQED FSFSKYRHRA LLLPELLEGV LQLLLGCLQA SAPNPFFFSQ
SLELVHEFVQ HRGLELFEAT ALRLEALAEA RDSEVGSDAS EHLRCLIAYV LKIISAVKRA
KSEQLHQSVC ARRRHRHCEY SYFLHHHRDL SGLPVSTFKQ AARRNPFEED SEGHDGEVRY
PERCCCLAAC VHQCLHLFQR LSPSGPAVLQ VLAGVQAVGI CCCMDPRSII GPMLQAFQAP
GLRSYQSHVL SVLSRLVLEQ LGGGQPSEKA KLSSCNICTL DSSQLPGLEE TLQGYGPKKE
SNLSTSHSPS YRSQGILPSR GAEDMLWKWD ALEAYQEIVF GEDWHLSQQI AGHVCQLTLR
GNAVVQWQLY THIFNPVLQR GVELTHHAQQ LGVSTTCSQV CSYHTNCLPV EVLLVYLQTL
PALLKSSRVV RDLFLSCNGL NQITELIYLD CTRLWALKVF ETLILNAWHH HVDSAVHEPE
RAEAQERESV LGLVEELSSR GAGEGPQSLT KFYEGLKEAC PHPKGKSAFS AVGRNRGEAH
LNTINFFLCV AFLCVSKEAD SDRDSANDSE DTSGYDSTAS EPLGGRLPCL SPDSVALPSK
EQIRRAADVW SVCRWVYMSS PVFQRQFFRL GGLDVCSRLM TMVIQKLTSK IKDSKFKKKR
ESKGKTSPSH VGSPTQALTG QFDNIASAAG TEETHQHDTL SPSQAESKSS DPTQRLEDEW
PLQSIRLLEA LLAICLHSAS SALQRFEPDL SFQLQSVEET LCEVRDQLSR SGVVNSELAV
PLFDSLLHVA LAEMFVSPDD IQEKPDKSAD VVAPPAGDLS EEVDEAQVSG ASPLGEEEGY
DADSESNPED STRQEEGVPQ GSGSGRLLFP EICLMELQLL ASGSPDLEVL CHVLQSLLDA
VKGHHNNAKL LYQQGGVKAI LTGFQNILSQ SDASYKGCQT ILMELLVAMV SDRITAEELA
LLTRLFLEKT PPTEILLRGL LQIVEANADI EPLCFMSFPM FPGAGVPGLS SSPGMRPHGT
AGGKGGVNTL LRGKLPLGRG EADLSRTGHL CTSPWHTAPF HLPLVGQNCW PHMASGFSAS
LWVRAGKDED GPYKNGMKKS IIFGALYKCI MQISIIYRCL HVLSMGSKAL MLQVWVNIST
GAFTFRICID PNDEVKAGLL AQAESGDGVL TSGRWQHVAL TYTQQPEGKK NIHGQLTLWV
GGIRKCDVSL DFTLPRKSSL SSDSNKTYCM LGHYQHSSEE QASPSARWDI GTLLLFNGMK
PAFYLYASGP DLTSIMPCKY GKPHGTLSKY VTQEGLQCEQ IRELLMRNTD VDIAPLIESL
AVVYAPSTPS LYTIYEPVIR LKGQAKSAMA SQRPFSAKEV QSSILEPPFL RTMMPCQALG
LHSVLHKIGG TGAFVFLFAR AVELSDCEET QALALQLLLS LVKNNQHRTH EMECYNGYSM
IHQVLIKPKC IVGYHVLKTL LDGCCSGSIL TIGEDGQFHL DAESTVVLQD LRLLSEILLD
WKIWAKAQCG VWETLLTALE ILIRVHHPQQ MFNIRQLLKA QVVHRFLLAC QVLQEHRDEY
LTSIPQEVCL SFVKIIQEVL GSPPDLDLLR LLYNFLLAVH PPTNTYVCHT PTSFYFSLHI
DGKLYQEKVQ SMMYLWQSSS SVLSLSPSVF TETPAEVRHA SSPEHGDEDL SLRPPSMGPS
LHSSPALTPR LTHGSVTGTA EPEEGTSWST QQDLGSTETL KRGGDELLSS CESAKTICDS
QNVGGDDEGS VHDGPAGSPP DSDDHFNWTS EEAPRRPDSL KGIQSFQRSH SNLASLGLAF
PAQNGSLTIA RWPTVADRAA PPDDWESYTY SPGYDRHSKT DSNCLVLICC GLYDLLRGVL
LLLPDLLLEE VMDKLIQPEA LLVLVNHSSP LIQQGVMKLL DAYFSRAQKE QKEKFLKNHG
FSLLANQLYL HQGSQGLLEC FLEMLLGRPV GIEEDLDLED MENISPFRKR CIIPVLGLLE
NSLYENSLVH NSLCLLLQLL NACPKLADIL LDHGLLYVLF NTLSTLNGLE NGIPPNDYKL
VVCDIQQLLV AVTIHSCSSS GSQYFRIIED LITLLGYMQT SKVRRTQEMA TALQFRVVQA
AIDFIKTTAN QDPQKSSSYV HVPTSPHHAL QPKRRSIAGR RRFTVAQSDS LMTRMRSVAS
DELNQMMQRR MSQENPIRAS ETELVQRLQR LVVLAVNRLI YQDIKYDFFD FLNFPESPDH
SMSVPLPGEH TTDENDSTPS TPIPPGNIKS FRKDILKLMM EGIKIGLGST GRGGAPRQQW
KRILWSCRDT FRVQIGRMLV HTLSPAVPLE DRKEALEFVH EQSYSEILRE SLSPSLEHGP
KLALYLYELL HDHRDALSKE EQAAANTFMT ALKLCGHRCI PPSAPAKPDL LKAIKEQLKY
ESEARTSKGA WEKKLANTEK SLLQRLDGKS KDISKIAADV TQNVSLRQGM ERKKVMQHIR
GLYKTDLSAS RHWQELVQQL THDRAVWYDQ SSYPTSWQLD PTEGPNRERR RLQRCYLTIP
NKYLLKDRHK LDDAIKAPLA FLFEDKTHSS SSIVKDKATS EPIRFTRKCV SVAPSRETAG
ELLLGKSGMY FVEDNVAETF DNQSPHGETE PASFSWTYEE IKEVHKRWWQ LRDNAMEIFL
TNGRTLLLAF DTTKFRDDVY HNILSSELPN LLEYGNISAL THLWSSGQIT NFEYLTHLNK
HAGRSFNDLM QYPVFPFILR DYTSETLDLQ DTSIYRILSK PIAVQSKEKE DRYVDNYRYL
EEEYKKGKVE DDPMPPVQPY HYGSHYSNSG TVLHFLVRLP PFTKMFLAYQ DQSFDIPDRT
FHSMNTTWRL SSYESMTDVK ELIPEFFYLP EFLVNREGFD FGVRQNSERV NHVNLPPWAR
NDPRLFILIH RQALESDQVS QTLCQWIDLV FGLKQKGKAA VHAINVFHPA TYFGMDVSAV
EDPVQRRALE TMIKTYGQTP RQLFSASHIS RAGTKLLSEA ELPAAMGLLV QLAFRESREQ
PKDTVYPSPL PWIKGLKWGE YVGSPSAPDP VVCFSQPHGE HFGSLLALPT RAICGLSRKF
CLMMIYSKEQ GVRSMHSTDI QWSAILSWGY TDNMLRLKSK QSEPPINFIQ CSPLHQVTSC
AWVPDSCQLF TGSKCGVITA YSNRFTTTMP TEMEVETQVH LYGHTAEVTG LFVCKPYSIL
ISVSRDGTCI LWDLNRLCYV QSLTGHKSPV NAVSASETTG DIATVCDSVG GGSDLRLWTI
NGDLIGHVHC REIICSVAFS NQPEGMSVNV IAGGLENGVV RLWSTWDLKP VREITFPKSN
RPIRSLTFSC DGHHLYTTNS EGTVIAWCRR DQQRMKLPMF YSFLSSYAAG
//
