ID A0A9J8B1R4_CYPCA Unreviewed; 893 AA.
AC A0A9J8B1R4;
DT 28-JUN-2023, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2023, sequence version 1.
DT 18-JUN-2025, entry version 12.
DE SubName: Full=Hyperpolarization activated cyclic nucleotide gated potassium channel 4 {ECO:0000313|Ensembl:ENSCCRP00000150807.1};
GN Name=HCN4 {ECO:0000313|Ensembl:ENSCCRP00000150807.1};
OS Cyprinus carpio carpio.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Cyprininae; Cyprinus.
OX NCBI_TaxID=630221 {ECO:0000313|Ensembl:ENSCCRP00000150807.1, ECO:0000313|Proteomes:UP001108240};
RN [1] {ECO:0000313|Ensembl:ENSCCRP00000150807.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=K(+)(in) = K(+)(out); Xref=Rhea:RHEA:29463, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034430};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Na(+)(in) = Na(+)(out); Xref=Rhea:RHEA:34963,
CC ChEBI:CHEBI:29101; Evidence={ECO:0000256|ARBA:ARBA00036239};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the potassium channel HCN family.
CC {ECO:0000256|ARBA:ARBA00006305}.
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DR Ensembl; ENSCCRT00000201401.1; ENSCCRP00000150807.1; ENSCCRG00000065953.1.
DR GeneTree; ENSGT00940000154743; -.
DR OMA; RISTAEW; -.
DR Proteomes; UP001108240; Unplaced.
DR GO; GO:0030424; C:axon; IEA:TreeGrafter.
DR GO; GO:0030425; C:dendrite; IEA:TreeGrafter.
DR GO; GO:0098855; C:HCN channel complex; IEA:TreeGrafter.
DR GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR GO; GO:0003254; P:regulation of membrane depolarization; IEA:TreeGrafter.
DR CDD; cd00038; CAP_ED; 1.
DR FunFam; 1.10.287.70:FF:000031; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, putative; 1.
DR FunFam; 1.10.287.630:FF:000002; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4; 1.
DR FunFam; 2.60.120.10:FF:000007; Putative potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013621; Ion_trans_N.
DR InterPro; IPR051413; K/Na_HCN_channel.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR PANTHER; PTHR45689:SF4; POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 4; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08412; Ion_trans_N; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 3: Inferred from homology;
KW cAMP {ECO:0000256|ARBA:ARBA00023149};
KW cAMP-binding {ECO:0000256|ARBA:ARBA00022566};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP001108240};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 195..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..449
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 854..887
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 527..642
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 750..790
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..116
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..781
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 893 AA; 100600 MW; BDCBE12AFBF183E2 CRC64;
MGDAEDTDKD TRRKSIRMKP LPAPTSAGET RSGESVIMET DIGRPVKTSS NGDCRRFRGS
LSSITSRHVH DSDVAEQRRL ITEGEVTPSE ESPPGAAGGG GGCEDAGASQ QQQIPGVPEQ
QAGFIKLEGI EQILPDDERF YQAGFMHRQF GAMLQPGVNK FSLRMFGSEK AVEREQERVK
SAGFWIIHPY SDFRFYWDLT MLLLMVGNLI IIPVGITFFK DEHTPPWIVF NVVSDTFFLM
DLVLNFRTGI VKEDNAEIIL DPQRIKIKYL RSWFVVDFIS SIPVDYIFLI VETRIDSDFY
KTARALRIVR FAKILSLLRL LRLSRLIRYI HQWEEIFHMT YDLASAMVRI VNLIGMMLLL
CHWDGCLQFL VPMLQDFPAD CWVSKNKMVN DTWGQQYSYA LFKAMSHMLC IGYGMYPPVG
MTDVWLTILS MIVGATCYAM FVGHATALIQ SLDSSRRQYQ EKYKQVEQYM SFHKLPADMR
QRIHDYYEHR YQGKMFDEES ILGELSEPLR EEIINFNCRK LVASMPLFAN ADPSFVTSTL
TKLRFEVFQP GDYIIREGTI GKKMYFIQHG VVSVLTKGNN ETKLSDGSYF GEICLLTRGR
RTASVRADTY CRLYSLSVDN FNDVLEEYPM MRRAFETVAL DRLDRIGKKN SILQHKVQHD
LNSGVLNYQE SEIIQQIVQH DRDMALCANL MQSPSPPAPL SPTPVIWAPL IQAPLQAAAA
TTSVAIALTH HPHLPATLFR PPVSILGSRN EPPSQLKRFQ TFAPNSGDPG SAGDSPSGSP
SKIRPGVDAS PKKTKKMIYL RSLQHFLFSF SHTVVISAGT EHWASGERVR VTVHLCLPGS
YYSVACRLCV CVCVCVCVCV CVCVCVCVCV CVCVCVCVCV CVCVCVCSSD ERA
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