ID A0A9J8BIX3_CYPCA Unreviewed; 472 AA.
AC A0A9J8BIX3;
DT 28-JUN-2023, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2023, sequence version 1.
DT 28-JAN-2026, entry version 12.
DE RecName: Full=Suppressor of cytokine signaling 5-like {ECO:0008006|Google:ProtNLM};
OS Cyprinus carpio carpio.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Cyprininae; Cyprinus.
OX NCBI_TaxID=630221 {ECO:0000313|Ensembl:ENSCCRP00000157152.1, ECO:0000313|Proteomes:UP001108240};
RN [1] {ECO:0000313|Ensembl:ENSCCRP00000157152.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR AlphaFoldDB; A0A9J8BIX3; -.
DR Ensembl; ENSCCRT00000121295.1; ENSCCRP00000162457.1; ENSCCRG00000069953.1.
DR Ensembl; ENSCCRT00000129672.1; ENSCCRP00000099026.1; ENSCCRG00000069953.1.
DR Ensembl; ENSCCRT00000142812.1; ENSCCRP00000157152.1; ENSCCRG00000069953.1.
DR GeneTree; ENSGT00940000164285; -.
DR OMA; SYRIHTQ; -.
DR Proteomes; UP001108240; Unplaced.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF18; SUPPRESSOR OF CYTOKINE SIGNALING 9 ISOFORM X1; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP001108240};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 320..415
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 410..459
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 261..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..83
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 472 AA; 52803 MW; 1F4A85D8C45CB352 CRC64;
MSLPEEAGDR GKERERGARP KVRQSRSEER RDGGRRKKKS QASHDLTSER PLSDGFEYGD
LLSGLQEPSS SSQVLGSSGS LPSERVSTKL SLGCDTESRA SGSSRTLRQK IQDAVGQCFP
IKTHSQVLSP SPSSRRKILL SELMLDSCPF PAGSDLAQKW YLIKQHTAPI SQAPVPDSGC
TLAVEDEEDR LRERRRISIE QGVEPPPNAQ IHTFEVTAQI NPLYKLGPKL APGMNELAGD
ERATLLLQSC LDTLDEVTAS TSPSDFDSGA ASPSPRSLTA VTLAQPDSPK SQDGLHRIHT
QIDYIHCLVP DLLRITNLPC YWGVMDRYQA ETLLEGKPEG TFLLRDSAQE DYLFSVSFRR
YGRSLHARIE QWNHNFSFDV HDPSVFHAPS VTGLLEHYKD PSSCMFFEPL LSNPIHRTQP
FSLQRICRAV ISSATTYDGI SALPLPSALK EHLKEYHYKQ RVRIRRLDTW WE
//
