ID A0A9J8BX57_CYPCA Unreviewed; 547 AA.
AC A0A9J8BX57;
DT 28-JUN-2023, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2023, sequence version 1.
DT 18-JUN-2025, entry version 9.
DE RecName: Full=Connector enhancer of kinase suppressor of ras 3-like {ECO:0008006|Google:ProtNLM};
OS Cyprinus carpio carpio.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Cyprininae; Cyprinus.
OX NCBI_TaxID=630221 {ECO:0000313|Ensembl:ENSCCRP00000162479.1, ECO:0000313|Proteomes:UP001108240};
RN [1] {ECO:0000313|Ensembl:ENSCCRP00000162479.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CNKSR family.
CC {ECO:0000256|ARBA:ARBA00009498}.
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DR Ensembl; ENSCCRT00000185087.1; ENSCCRP00000162479.1; ENSCCRG00000015664.2.
DR GeneTree; ENSGT00940000163429; -.
DR Proteomes; UP001108240; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR CDD; cd06748; PDZ_CNK1_2_3-like; 1.
DR FunFam; 2.30.42.10:FF:000060; Connector enhancer of kinase suppressor of Ras 2; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR010599; CNK2/3_dom.
DR InterPro; IPR051566; CNKSR.
DR InterPro; IPR017874; CRIC_domain.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12844; CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS; 1.
DR PANTHER; PTHR12844:SF17; CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 3; 1.
DR Pfam; PF06663; CNK2_3_dom; 1.
DR Pfam; PF10534; CRIC_ras_sig; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS51290; CRIC; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP001108240}.
FT DOMAIN 21..75
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 83..177
FT /note="CRIC"
FT /evidence="ECO:0000259|PROSITE:PS51290"
FT DOMAIN 214..296
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 301..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..424
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 547 AA; 61097 MW; 60D530B7D51F8CF2 CRC64;
MMDPRTEAQH RRRAAGLDER WLDDSLQQYV PHFERKKISG EQLLKISHQD LEELTMTRVG
HQELILEAVD LLCALNCGVE TDNLKTLVGQ MRAASNNLHN CASERRKNPT YDGGSPNKPP
NVFLTAVVEL IGAAKGMLAW LDRSPLTGIS DFTSIKNKII QLCLELTTTV QKDCTVFEME
EKILEVSSVL TGICDSTMRM TSDPLKSQMT CLEEVTITDI KAAEGMGIYI KSTYDGLHVI
TGTTENSPAD RTQRIHAGDE VIQVNRQTVV GWQLKNLVEK LREDPQNVTL MVKKRPSGTC
SFTPAPLKNM RWRPPVTQSP SYEPAAQSSR NPVQIKRPEK PAILDLYIPP PPSMPYSPRD
AETREYAAVK MRPKGSESPN SSLDLASRRR SNISDYNSKP SVNPAEVAAP KARLRQRTPS
RGKPRPMSMP VDTCLSVSDS PSRPWALGRK GDEILHRYLS NEQIPTISEE SPCYPLPYRP
TGERQLVRGV DHIRGSQCFI NADLHSSATI PYQEAVARKP AAKSSKRRPS EASVFSSWIA
RLKLLTH
//
