ID   A0A9J8CFN6_CYPCA        Unreviewed;       140 AA.
AC   A0A9J8CFN6;
DT   28-JUN-2023, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2023, sequence version 1.
DT   28-JAN-2026, entry version 12.
DE   RecName: Full=Receptor activity-modifying protein 1 {ECO:0000256|ARBA:ARBA00041071};
OS   Cyprinus carpio carpio.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=630221 {ECO:0000313|Ensembl:ENSCCRP00000168719.1, ECO:0000313|Proteomes:UP001108240};
RN   [1] {ECO:0000313|Ensembl:ENSCCRP00000168719.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSCCRP00000168719.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- FUNCTION: Accessory protein that interacts with and modulates the
CC       function of G-protein coupled receptors including calcitonin gene-
CC       related peptide type 1 receptor (CALCRL) and calcitonin receptor
CC       (CALCR). Required for the transport of CALCRL to the plasma membrane.
CC       Together with CALCRL, form the receptor complex for the calcitonin
CC       gene-related peptides CGRP1/CALCA and CGRP2/CALCB. Together with CALCR,
CC       form the AMYR1 receptor complex for amylin/IAPP and CGRP1/CALCA.
CC       {ECO:0000256|ARBA:ARBA00049570}.
CC   -!- SUBUNIT: Heterodimer of CALCRL and RAMP1; the interaction induces
CC       allosteric modulation of CALCRL function and CGRP1/CALCA and
CC       CGRP2/CALCB ligand specificity. Heterodimer of CALCR and RAMP1;
CC       interaction forms the AMYR1 receptor complex for amylin/IAPP and
CC       CGRP1/CALCA ligands. {ECO:0000256|ARBA:ARBA00049674}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC   -!- SIMILARITY: Belongs to the RAMP family.
CC       {ECO:0000256|ARBA:ARBA00007087}.
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DR   AlphaFoldDB; A0A9J8CFN6; -.
DR   Ensembl; ENSCCRT00000184559.1; ENSCCRP00000168719.1; ENSCCRG00000069316.1.
DR   GeneTree; ENSGT00940000159224; -.
DR   Proteomes; UP001108240; Unplaced.
DR   GO; GO:0009986; C:cell surface; IEA:TreeGrafter.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043235; C:receptor complex; IEA:TreeGrafter.
DR   GO; GO:0015026; F:coreceptor activity; IEA:InterPro.
DR   GO; GO:0006816; P:calcium ion transport; IEA:TreeGrafter.
DR   GO; GO:0032870; P:cellular response to hormone stimulus; IEA:TreeGrafter.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:TreeGrafter.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0072659; P:protein localization to plasma membrane; IEA:TreeGrafter.
DR   GO; GO:0031623; P:receptor internalization; IEA:TreeGrafter.
DR   GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   FunFam; 1.10.150.510:FF:000002; Receptor activity-modifying protein 1; 1.
DR   Gene3D; 1.10.150.510; Receptor activity modifying family; 1.
DR   InterPro; IPR006985; RAMP.
DR   InterPro; IPR038126; RAMP_sf.
DR   PANTHER; PTHR14076; RECEPTOR ACTIVITY MODIFYING PROTEIN RAMP; 1.
DR   PANTHER; PTHR14076:SF3; RECEPTOR ACTIVITY-MODIFYING PROTEIN 1; 1.
DR   Pfam; PF04901; RAMP; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP001108240};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        110..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   140 AA;  16418 MW;  287A2F6C5DAA0CE9 CRC64;
     MTVNCWRREN VNLSVLTTAC SSHYGNVIEE FCLAKFKLDM EVLDQRQWCS WEDTVESYGE
     LTNCTFLVAL KMNCFWPNRM VDEFFIRVHR HYFHDCSMSG RLLHDPPNRI LGPFIVVPIL
     VTLLMTALVV WRSKRSEGIV
//