ID A0A9L0I631_EQUAS Unreviewed; 240 AA.
AC A0A9L0I631;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 18-JUN-2025, entry version 10.
DE RecName: Full=Transmembrane protein 14A {ECO:0000256|ARBA:ARBA00067661};
GN Name=TMEM14A {ECO:0000313|Ensembl:ENSEASP00005035669.1};
OS Equus asinus (Donkey) (Equus africanus asinus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9793 {ECO:0000313|Ensembl:ENSEASP00005035669.1, ECO:0000313|Proteomes:UP000694387};
RN [1] {ECO:0000313|Ensembl:ENSEASP00005035669.1, ECO:0000313|Proteomes:UP000694387}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33293529;
RA Wang, C., Li, H., Guo, Y., Huang, J., Sun, Y., Min, J., Wang, J., Fang, X.,
RA Zhao, Z., Wang, S., Zhang, Y., Liu, Q., Jiang, Q., Wang, X., Guo, Y., Yang,
RA C., Wang, Y., Tian, F., Zhuang, G., Fan, Y., Gao, Q., Li, Y., Ju, Z., Li,
RA J., Li, R., Hou, M., Yang, G., Liu, G., Liu, W., Guo, J., Pan, S., Fan, G.,
RA Zhang, W., Zhang, R., Yu, J., Zhang, X., Yin, Q., Ji, C., Jin, Y., Yue, G.,
RA Liu, M., Xu, J., Liu, S., Jordana, J., Noce, A., Amills, M., Wu, D.D., Li,
RA S., Zhou, X. and Zhong, J.;
RT "Donkey genomes provide new insights into domestication and selection for
RT coat color.";
RL Nat. Commun. 11:6014-6014(2020).
RN [2] {ECO:0000313|Ensembl:ENSEASP00005035669.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- FUNCTION: Inhibits apoptosis via negative regulation of the
CC mitochondrial outer membrane permeabilization involved in apoptotic
CC signaling pathway. {ECO:0000256|ARBA:ARBA00055702}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004586}. Mitochondrion membrane
CC {ECO:0000256|ARBA:ARBA00004225}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004225}.
CC -!- SIMILARITY: Belongs to the TMEM14 family.
CC {ECO:0000256|ARBA:ARBA00007590}.
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DR Ensembl; ENSEAST00005044251.1; ENSEASP00005035669.1; ENSEASG00005028323.1.
DR GeneTree; ENSGT00940000158206; -.
DR Proteomes; UP000694387; Chromosome 8.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:TreeGrafter.
DR GO; GO:0070453; P:regulation of heme biosynthetic process; IEA:TreeGrafter.
DR FunFam; 1.10.10.1740:FF:000001; Transmembrane protein 14A; 1.
DR Gene3D; 6.10.250.1330; -; 1.
DR Gene3D; 1.10.10.1740; Transmembrane protein 14-like; 1.
DR InterPro; IPR005349; TMEM14.
DR InterPro; IPR044890; TMEM14_sf.
DR PANTHER; PTHR12668; TRANSMEMBRANE PROTEIN 14, 15; 1.
DR PANTHER; PTHR12668:SF11; TRANSMEMBRANE PROTEIN 14A; 1.
DR Pfam; PF03647; Tmemb_14; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000694387};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 137..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 14..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 64..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 240 AA; 24998 MW; 2A893CA3DE6E62DA CRC64;
TSSRLKLFRL LGSPLRRDPL PAKTCQSRSL RQEAVDLNPS SGPGPKGGRH SLLAAAGRLC
SAGRAGPSAG GREVAHARSG KGAAPSPGPR QALEGSAQGP KAPAASTGFR TPGTKFASSW
LPTVLFSASR RARGCSVAAL PMDLVGFGYA ALVTFGSILG YKRRGGVPSL IAGLFVGFLA
AYGAYRVSSD KRDVKLSLFT AFFLATIMGV RFKRSKKIMP AGLVAGLSLL MILRLVFLLL
//
