ID A0A9L0IBA9_EQUAS Unreviewed; 1109 AA.
AC A0A9L0IBA9;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 28-JAN-2026, entry version 13.
DE SubName: Full=Collagen type XVIII alpha 1 chain {ECO:0000313|Ensembl:ENSEASP00005037491.1};
GN Name=COL18A1 {ECO:0000313|Ensembl:ENSEASP00005037491.1};
OS Equus asinus (Donkey) (Equus africanus asinus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9793 {ECO:0000313|Ensembl:ENSEASP00005037491.1, ECO:0000313|Proteomes:UP000694387};
RN [1] {ECO:0000313|Ensembl:ENSEASP00005037491.1, ECO:0000313|Proteomes:UP000694387}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33293529;
RA Wang, C., Li, H., Guo, Y., Huang, J., Sun, Y., Min, J., Wang, J., Fang, X.,
RA Zhao, Z., Wang, S., Zhang, Y., Liu, Q., Jiang, Q., Wang, X., Guo, Y., Yang,
RA C., Wang, Y., Tian, F., Zhuang, G., Fan, Y., Gao, Q., Li, Y., Ju, Z., Li,
RA J., Li, R., Hou, M., Yang, G., Liu, G., Liu, W., Guo, J., Pan, S., Fan, G.,
RA Zhang, W., Zhang, R., Yu, J., Zhang, X., Yin, Q., Ji, C., Jin, Y., Yue, G.,
RA Liu, M., Xu, J., Liu, S., Jordana, J., Noce, A., Amills, M., Wu, D.D., Li,
RA S., Zhou, X. and Zhong, J.;
RT "Donkey genomes provide new insights into domestication and selection for
RT coat color.";
RL Nat. Commun. 11:6014-6014(2020).
RN [2] {ECO:0000313|Ensembl:ENSEASP00005037491.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSEASP00005037491.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
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DR AlphaFoldDB; A0A9L0IBA9; -.
DR Ensembl; ENSEAST00005075548.1; ENSEASP00005037491.1; ENSEASG00005038430.1.
DR GeneTree; ENSGT00940000158212; -.
DR Proteomes; UP000694387; Chromosome 18.
DR GO; GO:0005594; C:collagen type IX trimer; IEA:TreeGrafter.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0030020; F:extracellular matrix structural constituent conferring tensile strength; IEA:TreeGrafter.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:TreeGrafter.
DR CDD; cd00247; Endostatin-like; 1.
DR FunFam; 3.10.100.10:FF:000008; collagen alpha-1(XVIII) chain isoform X1; 1.
DR FunFam; 3.40.1620.70:FF:000003; Collagen type XVIII alpha 1; 1.
DR Gene3D; 3.40.1620.70; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR050149; Collagen_superfamily.
DR InterPro; IPR010515; Collagenase_NC10/endostatin.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR045463; XV/XVIII_trimerization_dom.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24023:SF372; COLLAGEN ALPHA-1(XVI) CHAIN; 1.
DR Pfam; PF01391; Collagen; 3.
DR Pfam; PF20010; Collagen_trimer; 1.
DR Pfam; PF06482; Endostatin; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
PE 4: Predicted;
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Reference proteome {ECO:0000313|Proteomes:UP000694387}.
FT DOMAIN 799..847
FT /note="Collagen type XV/XVIII trimerization"
FT /evidence="ECO:0000259|Pfam:PF20010"
FT DOMAIN 935..1104
FT /note="Collagenase NC10/endostatin"
FT /evidence="ECO:0000259|Pfam:PF06482"
FT REGION 1..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..11
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..29
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..164
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..229
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..268
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..296
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..312
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..354
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..377
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..438
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..466
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..483
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..510
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..530
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 611..623
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..698
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 710..722
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..768
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 778..790
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1109 AA; 111349 MW; 3C9EDDEA5A354EA2 CRC64;
MIAELRVRAD PHVSPVHCLE DDDDDDDGAS GDFGSGLEEP RERLGEEPGT SLTLGLPDAP
PVTSPPLAGS SDVEDSRTEE IEEETTVSSI GAHTLPGSDP AATWDGSAWS PGGSLREGGL
KGQKGEPGLP GPVGPQGPAG PAMHSPDAQP IPGPQGPPGP PGPPGKDGAP GRDGEPGDPG
EDGKPGDTGP QGFPGTPGDV GPKGEKGDPG VGPRGPPGPQ GPPGPPGPSF RPDKLTFIDM
EGSGFGGDLE TLRGPRGFPG PPGPPGVPGL PGEPGRFGMN SSDVPGPAGL PGVPGRQGPP
GLPGPPGPPG PPGRDGRPGG TGQKGSLGEA GPPGPKGSKG DPGPIGAPGE NGLAGPPGPA
GPPGPPGPPG LPGPPGPGLA AGFDDMEGSG GPFWSTARGA DGPQGLPGLP GVKGDPGPAG
PPGTKGEVGA DGGPGFPGLP GREGAAGAQG PKGEKGTQGE KGDPGKDGVG QPGLPGPPGP
PGPVVYVSEQ DRAVASVPGP EGRPGFAGFP GPAGPKGDLG SKGQQGLPGP KGEKGEPGAV
FGPDGGVLTA SQKGAKGEPG FRGPPGPYGR PGHKGEIGFP GRPGRPGMNG LKGEKGEPGD
ASVRFGMRGL PGPPGPPGPP GLPGTPVYDT NAFLESGRPG PPGLPGHQGP SGPKGDKGEV
GPPGPPGQFP LDLLQLEAEM KGEKGDRGPA GQKGERGEPG AGGFFGSSVP GPPGPPGYPG
IPGPKGESIR GQPGPPGPQG PPGIGYEGRQ GPPGPPGPPG PPGPPSFPGP YRQTISVPGP
PGPPGPPGPP GTMGTSSGVR IWATYQTMLD KVPEVPEGWL IFVAEREELY VRVRNGFRRV
LLDARMPLPH GTDNEVAALQ PPVVQLHEGN PYPRREVPHS TARPWRADDI LASPPRLPDP
QPYPGAPHHG SYVHLRPARP TSSLTHTHQD FQPVLHLIAL NSPQSGGLRG IRGADFQCFQ
QARAVGLAGT FRAFLSSRLQ DLYSIVRRAD RASVPIVNLR DEVLFPNWEA LFTGSEGRLK
PGARIFSFDG RDVLQHPAWP QKSVWHGSDP SGRRLTESYC ETWRTEATAA TGQASSLLAG
RLLEQKSASC HNAFIVLCIE NSFMTSSSK
//
