ID A0A9L0JJ76_EQUAS Unreviewed; 490 AA.
AC A0A9L0JJ76;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 18-JUN-2025, entry version 11.
DE RecName: Full=HTH psq-type domain-containing protein {ECO:0000259|PROSITE:PS50960};
OS Equus asinus (Donkey) (Equus africanus asinus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9793 {ECO:0000313|Ensembl:ENSEASP00005053249.1, ECO:0000313|Proteomes:UP000694387};
RN [1] {ECO:0000313|Ensembl:ENSEASP00005053249.1, ECO:0000313|Proteomes:UP000694387}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33293529;
RA Wang, C., Li, H., Guo, Y., Huang, J., Sun, Y., Min, J., Wang, J., Fang, X.,
RA Zhao, Z., Wang, S., Zhang, Y., Liu, Q., Jiang, Q., Wang, X., Guo, Y., Yang,
RA C., Wang, Y., Tian, F., Zhuang, G., Fan, Y., Gao, Q., Li, Y., Ju, Z., Li,
RA J., Li, R., Hou, M., Yang, G., Liu, G., Liu, W., Guo, J., Pan, S., Fan, G.,
RA Zhang, W., Zhang, R., Yu, J., Zhang, X., Yin, Q., Ji, C., Jin, Y., Yue, G.,
RA Liu, M., Xu, J., Liu, S., Jordana, J., Noce, A., Amills, M., Wu, D.D., Li,
RA S., Zhou, X. and Zhong, J.;
RT "Donkey genomes provide new insights into domestication and selection for
RT coat color.";
RL Nat. Commun. 11:6014-6014(2020).
RN [2] {ECO:0000313|Ensembl:ENSEASP00005053249.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00320}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSEAST00005082145.1; ENSEASP00005053249.1; ENSEASG00005030813.1.
DR GeneTree; ENSGT00940000162414; -.
DR Proteomes; UP000694387; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:TreeGrafter.
DR FunFam; 1.10.10.60:FF:000019; Ligand-dependent corepressor isoform 1; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeodomain-like_sf.
DR InterPro; IPR007889; HTH_Psq.
DR PANTHER; PTHR21545:SF10; LIGAND-DEPENDENT NUCLEAR RECEPTOR COREPRESSOR-LIKE PROTEIN; 1.
DR PANTHER; PTHR21545; TRANSCRIPTION FACTOR MLR1/2; 1.
DR Pfam; PF05225; HTH_psq; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00320};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00320}; Reference proteome {ECO:0000313|Proteomes:UP000694387};
KW Transcription {ECO:0000256|ARBA:ARBA00023015};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 404..456
FT /note="HTH psq-type"
FT /evidence="ECO:0000259|PROSITE:PS50960"
FT DNA_BIND 432..452
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00320"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 383..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..490
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 490 AA; 54211 MW; 6B7D150EF6F205FE CRC64;
ALSELDCLPS LDSSQSTPTE ELSSQGQSNT EKTECQAENY LNALFRKKDL PQNCDPNIPL
VAQELMKKMI RQFAIEYISK SGKIQENRNG SIGPSLICKS IQMNQAENSL QEEQEGPLDL
TVNRMQEQNT QQGDGVLDLS TKKTSIKSEE SSICDPSENS MAGRLQRNRE DYVERSAEFA
DGLLSKALKD IQSGALDRNK AGIPQKTLLL HLEALPAGKP ASFKNKTRDF NDSYSYKDSE
ETCAVLQKVA LWARAQAERT EKSKLNLLET SGLRFPTASS YLHQLTLQKM VAQFKEKNES
LQYETSHPTV QLKIPQLRVS SVSKPQPDGP GLLDVMYQVS KTSPVLEGSK KIECSGPVTH
SSVDSYFLHG DLSPLCLNSK NGTVDGTSEN TEDGLDRKDN KQPRKNRGRY RQYDHEIMEE
AIAMVMSGKM SASKAQGIYG VPHGTLEYKV EERSGTLKTP PPKKLRVPDT GLYSMTDSGT
GSCKNSSKPV
//
