ID A0A9L0K303_EQUAS Unreviewed; 479 AA.
AC A0A9L0K303;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 18-JUN-2025, entry version 11.
DE RecName: Full=Sodium/nucleoside cotransporter {ECO:0000256|RuleBase:RU362018};
GN Name=LOC123283288 {ECO:0000313|Ensembl:ENSEASP00005056722.1};
OS Equus asinus (Donkey) (Equus africanus asinus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9793 {ECO:0000313|Ensembl:ENSEASP00005056722.1, ECO:0000313|Proteomes:UP000694387};
RN [1] {ECO:0000313|Ensembl:ENSEASP00005056722.1, ECO:0000313|Proteomes:UP000694387}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33293529;
RA Wang, C., Li, H., Guo, Y., Huang, J., Sun, Y., Min, J., Wang, J., Fang, X.,
RA Zhao, Z., Wang, S., Zhang, Y., Liu, Q., Jiang, Q., Wang, X., Guo, Y., Yang,
RA C., Wang, Y., Tian, F., Zhuang, G., Fan, Y., Gao, Q., Li, Y., Ju, Z., Li,
RA J., Li, R., Hou, M., Yang, G., Liu, G., Liu, W., Guo, J., Pan, S., Fan, G.,
RA Zhang, W., Zhang, R., Yu, J., Zhang, X., Yin, Q., Ji, C., Jin, Y., Yue, G.,
RA Liu, M., Xu, J., Liu, S., Jordana, J., Noce, A., Amills, M., Wu, D.D., Li,
RA S., Zhou, X. and Zhong, J.;
RT "Donkey genomes provide new insights into domestication and selection for
RT coat color.";
RL Nat. Commun. 11:6014-6014(2020).
RN [2] {ECO:0000313|Ensembl:ENSEASP00005056722.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the concentrative nucleoside transporter (CNT)
CC (TC 2.A.41) family. {ECO:0000256|ARBA:ARBA00009033,
CC ECO:0000256|RuleBase:RU362018}.
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DR Ensembl; ENSEAST00005067199.1; ENSEASP00005056722.1; ENSEASG00005017900.2.
DR GeneTree; ENSGT00390000016025; -.
DR Proteomes; UP000694387; Chromosome 2.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005415; F:nucleoside:sodium symporter activity; IEA:TreeGrafter.
DR GO; GO:0015211; F:purine nucleoside transmembrane transporter activity; IEA:TreeGrafter.
DR GO; GO:0001895; P:retina homeostasis; IEA:TreeGrafter.
DR InterPro; IPR008276; C_nuclsd_transpt.
DR InterPro; IPR018270; C_nuclsd_transpt_met_bac.
DR InterPro; IPR011657; CNT_C_dom.
DR InterPro; IPR002668; CNT_N_dom.
DR InterPro; IPR011642; Gate_dom.
DR NCBIfam; TIGR00804; nupC; 1.
DR PANTHER; PTHR10590; SODIUM/NUCLEOSIDE COTRANSPORTER; 1.
DR PANTHER; PTHR10590:SF11; SODIUM_NUCLEOSIDE COTRANSPORTER 2; 1.
DR Pfam; PF07670; Gate; 1.
DR Pfam; PF07662; Nucleos_tra2_C; 1.
DR Pfam; PF01773; Nucleos_tra2_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362018};
KW Reference proteome {ECO:0000313|Proteomes:UP000694387};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362018};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362018}; Transport {ECO:0000256|RuleBase:RU362018}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..479
FT /note="Sodium/nucleoside cotransporter"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040477006"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 64..81
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 194..211
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 223..247
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 253..271
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 306..327
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT DOMAIN 68..140
FT /note="Concentrative nucleoside transporter N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01773"
FT DOMAIN 149..246
FT /note="Nucleoside transporter/FeoB GTPase Gate"
FT /evidence="ECO:0000259|Pfam:PF07670"
FT DOMAIN 252..398
FT /note="Concentrative nucleoside transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07662"
SQ SEQUENCE 479 AA; 52836 MW; 3F052BCE4CC95047 CRC64;
LLLTLALALF VLTCLFFGEK LTACLKPFKS SCLKLWMKWV FAGVSLVGLI LWLALDTAQR
PEQLISFAGI CMFVLILFAC SKHHSAVSWR TVLWGLGLQF VFGILVIRTD PGFNAFQWLG
DQIQIFLNYT VAGSSFVYGD TLIKNVFAFQ SLPIILFFGC MMSILYYLGL VQWIVQKIAW
FLQVTMGTTP TETLAVAGNI FVGMTEAPLL IRPYLADMTL SEIHAVMTGG FATISGTVLG
SFISFGIDAS SLISASVMAA PSALALSKLV YPEVEESKFK NEEGVKLPRG KEKNILEAAS
SGATDAIGLA ANVAANLIAF LAVLAFINAA LSWLGELVDI QGLTFQVICS YILRPMVFMM
GVEWADCPIV AEMVGIKFFT NEFVAYQQLS QYKNKRLSGV EEWIGGEKQW ISVSDDSEEH
KYTCWVFTVG VVQDAHCFFF SNKVCFLVRK IGPELTSVAN LPLFKKIFLP KALVHSCIF
//
