ID A0A9L0R041_HORSE Unreviewed; 1013 AA.
AC A0A9L0R041;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 18-JUN-2025, entry version 11.
DE RecName: Full=Brother of CDO {ECO:0000256|ARBA:ARBA00067175};
GN Name=BOC {ECO:0000313|VGNC:VGNC:15860};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000057383.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000057383.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000057383.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000057383.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000057383.1};
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR Ensembl; ENSECAT00000133865.1; ENSECAP00000057383.1; ENSECAG00000022602.4.
DR VGNC; VGNC:15860; BOC.
DR GeneTree; ENSGT00940000158810; -.
DR Proteomes; UP000002281; Chromosome 19.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 3.
DR CDD; cd00096; Ig; 1.
DR FunFam; 2.60.40.10:FF:000655; brother of CDO isoform X1; 1.
DR FunFam; 2.60.40.10:FF:000852; brother of CDO isoform X1; 1.
DR FunFam; 2.60.40.10:FF:001263; brother of CDO isoform X1; 1.
DR FunFam; 2.60.40.10:FF:000205; Cell adhesion associated, oncogene regulated; 1.
DR FunFam; 2.60.40.10:FF:000327; Cell adhesion associated, oncogene regulated; 1.
DR FunFam; 2.60.40.10:FF:000352; Cell adhesion molecule-related/down-regulated by oncogenes; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170:SF3; BROTHER OF CDO; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF16625; ISET-FN3_linker; 1.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 753..776
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..110
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 132..201
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 220..306
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 371..469
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 506..601
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 610..710
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 310..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 874..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 923..942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 994..1013
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..360
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..733
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 923..937
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1013 AA; 110779 MW; 3B61EAFFAF6F2E54 CRC64;
MTHEVLSTLT PSEGGSNGVE EADLQDFKLD VQHVIEVDEG NTAVIACHLP ESHPKAQVRY
SVKQEWLEAS RDNYLIMPSG NLQIVNASQE DEGMYKCAAY NPVTQEVKTS GSSDRLRVRR
STAEAARIIY PPEAQSIIVT KGQSLILECV ASGIPPPRVT WAKDGSSVAG YNKTRFLLSN
LLIDTTSEED SGTYRCMADN GVGEPGAAVI LYNVQVFEPP EVTMELSQLV IPWGQSAKLT
CEVRGNPPPS VLWLRNAVPL TSSQRLRLSR RALRVVSVGP EDEGVYQCMA ENEVGSAHAV
VQLRTARPDT TLRPWRDAKP DTATPPMLPS RPGSPDQMLR GRQGLPRPPT AAQPASPPCP
GEKGQVAPAE APVILSSPRT SKTDSYELVW RPRHEGSSRA PILYYVVKHR KQVTNSSDDW
TISGIPANQH RLTLTRLDPG SLYEVEMAAY NCAGEGQTAM VTFRTGRRPK PEIMASKEQQ
IQRDDPGASP QSSSQPDHGR LSPPEAPDRP TISMASETSV YVTWIPRGNG GFPIQSFRVE
YKKLKKVGDW ILATSAIPPS RLSVEITGLE KGTSYKFRVR ALNMLGESEP SAPSRPYMVS
GYSGRVYERP VAGPYITFTD AINETTIMLK WMYIPASNNN TPIHGFYIYY RPTDSDNDSD
YKKDMVEGDR YWHSISHLQP ETSYDIKMQC FNEGGESEFS NVMICETKAR KSSGQPGRLP
PPTLALPQPP PPGTIERPVG TGTMVARSSD LPYLVVGVVL GSIVLIIVAF IPFCLWRAWS
KQKHTTDLGF PRSALLSSSC QYTMVPLGGL PGHRTNGQPY LSGTNGRACA NGLHVNRGCP
AAAMGYPGLK PQQHCPGELP QQDDTSSLLR QTILGNGYDP HSHQVPRGPK SNPDEGPFLY
TLPDDSTRQL LQTHQDCLQI QEQPAATGQS GRRSVPQNPG LEATWDPLFH PGPPCCLGLV
PVEEVDSPDS CQVGGGDWCP QHPTGAYRGQ ELGMRLPSSP PVHVSFETPP PTI
//
