ID A0A9L0R7A3_HORSE Unreviewed; 138 AA.
AC A0A9L0R7A3;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 18-JUN-2025, entry version 11.
DE RecName: Full=Leptin receptor gene-related protein {ECO:0000256|ARBA:ARBA00040088};
DE AltName: Full=Endospanin-1 {ECO:0000256|ARBA:ARBA00042171};
DE AltName: Full=OB-R gene-related protein {ECO:0000256|ARBA:ARBA00042793};
GN Name=LEPROT {ECO:0000313|Ensembl:ENSECAP00000058345.1,
GN ECO:0000313|VGNC:VGNC:19634};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000058345.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000058345.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000058345.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000058345.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000058345.1};
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBUNIT: Interacts with LEPR. Interacts with RAB13.
CC {ECO:0000256|ARBA:ARBA00046770}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004608}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}.
CC -!- SIMILARITY: Belongs to the OB-RGRP/VPS55 family.
CC {ECO:0000256|ARBA:ARBA00005645}.
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DR Ensembl; ENSECAT00000118075.1; ENSECAP00000058345.1; ENSECAG00000016346.4.
DR VGNC; VGNC:19634; LEPROT.
DR GeneTree; ENSGT00390000006503; -.
DR Proteomes; UP000002281; Chromosome 5.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR007262; Vps55/LEPROT.
DR PANTHER; PTHR12050:SF3; LEPTIN RECEPTOR GENE-RELATED PROTEIN; 1.
DR PANTHER; PTHR12050; LEPTIN RECEPTOR-RELATED; 1.
DR Pfam; PF04133; Vps55; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 32..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 71..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 138 AA; 15095 MW; 54D3FA61A54D8877 CRC64;
MAGVKALVAL SFSGAIGLTF LMLGCALEDY GVYWPLFVLI FYVISPIPHF IAKRATDDSD
AASSACRELA YFFTTGIVVS AFGLPIILAR VAVEVEQTLP LLKRGLCIGS AFQRVRCGKR
EQGATLRWRN PTHRLSAR
//
