ID A0A9L0SV11_HORSE Unreviewed; 356 AA.
AC A0A9L0SV11;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 18-JUN-2025, entry version 11.
DE RecName: Full=HTH CENPB-type domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=LOC106782351 {ECO:0000313|Ensembl:ENSECAP00000077814.1};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000077814.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000077814.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000077814.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000077814.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000077814.1};
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00320}.
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DR RefSeq; XP_023481624.1; XM_023625856.2.
DR RefSeq; XP_023481625.1; XM_023625857.2.
DR RefSeq; XP_023481626.1; XM_023625858.2.
DR RefSeq; XP_070102152.1; XM_070246051.1.
DR Ensembl; ENSECAT00000093778.1; ENSECAP00000077814.1; ENSECAG00000045308.1.
DR Ensembl; ENSECAT00000100466.1; ENSECAP00000060721.1; ENSECAG00000045308.1.
DR Ensembl; ENSECAT00000105349.1; ENSECAP00000066451.1; ENSECAG00000045308.1.
DR Ensembl; ENSECAT00000107323.1; ENSECAP00000079210.1; ENSECAG00000045308.1.
DR Ensembl; ENSECAT00000134199.1; ENSECAP00000062875.1; ENSECAG00000045308.1.
DR Ensembl; ENSECAT00000137100.1; ENSECAP00000086251.1; ENSECAG00000045308.1.
DR Ensembl; ENSECAT00000148489.1; ENSECAP00000082636.1; ENSECAG00000045308.1.
DR GeneID; 106782351; -.
DR GeneTree; ENSGT00940000155163; -.
DR OrthoDB; 9802028at2759; -.
DR Proteomes; UP000002281; Chromosome 21.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR InterPro; IPR050863; CenT-Element_Derived.
DR InterPro; IPR009057; Homeodomain-like_sf.
DR InterPro; IPR006600; HTH_CenpB_DNA-bd_dom.
DR InterPro; IPR007889; HTH_Psq.
DR PANTHER; PTHR19303:SF26; TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 1; 1.
DR PANTHER; PTHR19303; TRANSPOSON; 1.
DR Pfam; PF04218; CENP-B_N; 1.
DR Pfam; PF03221; HTH_Tnp_Tc5; 1.
DR SMART; SM00674; CENPB; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS51253; HTH_CENPB; 1.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00320};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00320};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 43..94
FT /note="HTH psq-type"
FT /evidence="ECO:0000259|PROSITE:PS50960"
FT DOMAIN 107..186
FT /note="HTH CENPB-type"
FT /evidence="ECO:0000259|PROSITE:PS51253"
FT DNA_BIND 70..90
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00320"
FT REGION 324..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 356 AA; 39893 MW; 5A3F26EB61442CD7 CRC64;
MLCVLAAPLT VLLSLPLLGP PCFLSNSFEI RPINNPAMAS KCSSERKSRT SLTLNQKLEM
IKLSEEGMSK AEIGRRLGLL RQTVSQVVNA KEKFLKEIKS ATPVNTRMIR KRNSLIADME
KVLVVWIEDQ TSHNIPLSQS LIQSKALTLF NSMKAERGKE VAEQKFEASR GWFMRFKERS
RLRNMRVRGE AASADTEAAA SYPADVAGLL QSHDKTLADK ELLLVDEQRK WLLEMKSAPG
EDAVKIVEMT TKDLEYYINL VDKAAAGFER IDSDFERSSA VGKMLSNSIA CYRKIVSERK
NQSMRRQTSL LSYFKKLQQP PQLSAATTLI SQQPSTSRQD PPPAKRLRLA EGADDG
//
