ID A0A9L0SYT0_HORSE Unreviewed; 1142 AA.
AC A0A9L0SYT0;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 18-JUN-2025, entry version 11.
DE SubName: Full=Integrin subunit alpha M {ECO:0000313|Ensembl:ENSECAP00000080114.1};
GN Name=ITGAM {ECO:0000313|Ensembl:ENSECAP00000080114.1,
GN ECO:0000313|VGNC:VGNC:19173};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000080114.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000080114.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000080114.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000080114.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000080114.1};
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR RefSeq; XP_005598797.2; XM_005598740.4.
DR SMR; A0A9L0SYT0; -.
DR Ensembl; ENSECAT00000083211.1; ENSECAP00000080114.1; ENSECAG00000017418.4.
DR GeneID; 100064803; -.
DR VGNC; VGNC:19173; ITGAM.
DR GeneTree; ENSGT00940000161282; -.
DR OMA; CQRIKCD; -.
DR Proteomes; UP000002281; Chromosome 13.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR FunFam; 2.130.10.130:FF:000005; Integrin alpha L; 1.
DR FunFam; 3.40.50.410:FF:000067; Integrin alpha M; 1.
DR FunFam; 1.20.5.930:FF:000004; Integrin subunit alpha M; 1.
DR FunFam; 2.60.40.1460:FF:000001; Integrin, alpha V; 1.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 2.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR048633; ITGAX-like_Ig_3.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF130; INTEGRIN ALPHA-M; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF00357; Integrin_alpha; 1.
DR Pfam; PF21520; ITGAX-like_Ig_3; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 5.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 17..1142
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5040539179"
FT TRANSMEM 1100..1122
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 18..75
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 150..328
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 443..503
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 506..564
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 569..629
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1142 AA; 126629 MW; ECD21F3CECCB7F56 CRC64;
MTHRVLLLTA LTLCHGFNLD TENAMIFQEN ARGFGHSVVQ LEGSRVVVGA PQEIKAANQT
GSLYQCDYST ASCEPIPMQV PLESVNMSLG LSLAFATNPF RLLACGPTVH QICKEHIYVN
GFCFLFGSNL RQQPQRFPEA LRECPQQESD IAFLIDGSGS IYENDFQKMK EFVTIVMNQF
KKSKTLFSLM QYSDTFQTHF TFKEFANNPN PGSLVRPINQ LGGRTHTATG IRKVVRELFH
SRNGARKNAL KILVVITDGE KFGDRLEYED VIPEADQEGI IRYVIGVGIA FSIEKSREEL
NTIASKPARD HVFRVNNFEA LKTIQNQLQE KIFAIEGTQT GSTSSFEHEM SQEGFSAAVT
SSGPLLGAVG SFDWAGGAFL HTSRDKFTFI NLTMVDPDMK DAYLGYAVEV VSRRQVQNFV
MGAPRYQHTG LVAMFRQNAG AWENNAYIKG SQIGSYFGAS LCSVDVDRDG SSDLVLIGAP
HYYEQTRGGQ VSVCPLPRGR AKWQCKSVLR GEQGHPWGGF GAALTVLGDV NGDKLMDVAI
GAPGEQENQG AVYLFHGTSG LGISPSHSQR IAGSQLLPRL QYFGQSLSGG RDLTMDGLVD
LAVGAQGHVL LLRSQPVLRV EVTMAFTPGE VARNIFDCRD QVVRNQTAGE VRVCLRVRKS
TPDRLREGEI QSIVTYDLAL DPNRLLRRAV FDETKNSTCR QIQNLGLNQE CKTLKLLLPK
CGQDSVAPIV LRLNFSLVGK PSSSFGNLRP VLAVDAQRLF TALFPFEKNC GSDGICEDDL
SITLSFMSLN TLVVGGPREF NVTVTVKNQG EDSYNTQVTF FYPPGLSYRM LSRDQEQYSQ
RCACNSTEEP GALKSCTCNI SRPIFPENSE VTFNITFVMN STASFGNRLL LKAKVTSENN
MPQTNKTQFQ LELPVKYAVY MVVTSGEAST KYLNFTASEK TSRIIKHEYQ FKNLGQRTPP
ISVVFWVPIR LNQSAVWDHP QVTFSQELSR TCHTKERVPP LSDFLVELKK TPVLNCSIAV
CQRIQCDIPS FGIQQEFNVA LEGNLSFGWY SKALQNYLQI VSTAEILFND SIFTLLPGQE
AFVRAQTDTK VELYEMHDPV PLIVGSSVGG LVLLALITAG LYKLGFFKRQ YKDMMNEAAP
PQ
//
