ID A0A9L0SZ16_HORSE Unreviewed; 841 AA.
AC A0A9L0SZ16;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 18-JUN-2025, entry version 11.
DE SubName: Full=Synaptonemal complex protein 2 like {ECO:0000313|Ensembl:ENSECAP00000079230.1};
GN Name=SYCP2L {ECO:0000313|VGNC:VGNC:56696};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000079230.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000079230.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000079230.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000079230.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000079230.1};
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SYCP2 family.
CC {ECO:0000256|ARBA:ARBA00007960}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSECAT00000072447.2; ENSECAP00000079230.1; ENSECAG00000018652.4.
DR VGNC; VGNC:56696; SYCP2L.
DR GeneTree; ENSGT00530000063859; -.
DR Proteomes; UP000002281; Chromosome 20.
DR GO; GO:0000779; C:condensed chromosome, centromeric region; IBA:GO_Central.
DR GO; GO:0001674; C:female germ cell nucleus; IEA:Ensembl.
DR GO; GO:0000800; C:lateral element; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0043069; P:negative regulation of programmed cell death; IEA:Ensembl.
DR InterPro; IPR024835; SYCP2-like.
DR InterPro; IPR041322; SYCP2_ARLD.
DR InterPro; IPR040560; SYCP2_SLD.
DR PANTHER; PTHR15607:SF14; SYNAPTONEMAL COMPLEX PROTEIN 2-LIKE; 1.
DR PANTHER; PTHR15607; SYNAPTONEMAL COMPLEX PROTEIN-RELATED; 1.
DR Pfam; PF18581; SYCP2_ARLD; 1.
DR Pfam; PF18584; SYCP2_SLD; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 27..200
FT /note="Synaptonemal complex protein 2 armadillo-repeat-
FT like"
FT /evidence="ECO:0000259|Pfam:PF18581"
FT DOMAIN 292..402
FT /note="Synaptonemal complex protein 2 Spt16M-like"
FT /evidence="ECO:0000259|Pfam:PF18584"
FT REGION 463..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 789..819
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 463..473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..489
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..539
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..552
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..579
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..600
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 841 AA; 96512 MW; 506B788FDA8EC3E7 CRC64;
MQAEKEGPLQ SAKEDDGSGM AVDAFYLQSL ITDAFHDKGF QKIEEYFQQR EHHIPQKYNH
LLLYRLDRSI SKELDKNEFR NVSLLLKCIQ RFLIDGLRED EPLLVQQRLI PKMVSWFERT
TGFLTMADLA SDTSLVNVTE DFFDTALIIS TRSSKGKIQM LDSFIFPLGS LVTEKTVNHL
IQREALKTLN FILQAVPREE RKQLSLSEGP CLLMKDLART ILTVGDYDQQ VALSEALCRL
TTKKSRVDLV HQWFEDDVIA EAFKEIKDRE FETDSRQFLN HLNNRLGDQR RVYSFPCMAA
FADGNEMKKP ADEKLEKFWI DFNLGSQSVT FYIDNTESAL WDSIILSKEA VINFSIIETE
RMKMLVINLK PINIRNKEVM KIEIHFDLQF DISEASIKAL GEDKQMLPDQ TKFSEHFGEF
AKDDIEFPSS DKRETDQAEE STKLAELTSA GDDRCLITLP FNQSEPAQTS TPSHSHEKSK
LDDTEKVASE LENSSDLQEA SVKIQASKLN DKSREESAFE DDGKQETRMS KLDYRKHLFS
ESNPDSSTST SELPWTNDQK RKSLKPYSGR KKTRIRSRVK ILPLFPPSSG SDREKDEKNT
SRQNNATPPK VSGKKFQGSS VFLTPEDSAQ KTELQSPHPL SNLSSLEHSG VEENVSKTVN
QESLMKSTSF KHKLQNLEDR DISDDSFAKW KQSKLEEDDV PGSLSSVTEE ADLAEGISTP
SLEVVLENLN DSSIITTFEN FTRELKRQYE LRYRRSLLHS KNVKQAPDCL MKLLNQIHQC
RLNKLEQFRT FVLQELSNLE EAIQDLKHLE KDVLEFCRKQ SDDLKSFCDL QVLRLNPIQP
S
//
