ID A0A9L0T8R5_HORSE Unreviewed; 2331 AA.
AC A0A9L0T8R5;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 18-JUN-2025, entry version 11.
DE RecName: Full=Nucleoprotein TPR {ECO:0000256|ARBA:ARBA00019789};
DE AltName: Full=Megator {ECO:0000256|ARBA:ARBA00083105};
DE AltName: Full=NPC-associated intranuclear protein {ECO:0000256|ARBA:ARBA00077074};
DE AltName: Full=Translocated promoter region protein {ECO:0000256|ARBA:ARBA00079318};
GN Name=TPR {ECO:0000313|Ensembl:ENSECAP00000082964.1,
GN ECO:0000313|VGNC:VGNC:50899};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000082964.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000082964.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000082964.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000082964.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000082964.1};
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186}. Nucleus membrane
CC {ECO:0000256|ARBA:ARBA00004335}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004335}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004335}. Nucleus membrane
CC {ECO:0000256|ARBA:ARBA00004620}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004620}; Nucleoplasmic side
CC {ECO:0000256|ARBA:ARBA00004620}. Nucleus, nuclear pore complex
CC {ECO:0000256|ARBA:ARBA00004567}.
CC -!- SIMILARITY: Belongs to the TPR family. {ECO:0000256|ARBA:ARBA00005274}.
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DR Ensembl; ENSECAT00000143375.1; ENSECAP00000082964.1; ENSECAG00000020724.4.
DR VGNC; VGNC:50899; TPR.
DR GeneTree; ENSGT00730000111014; -.
DR Proteomes; UP000002281; Chromosome 5.
DR GO; GO:0034399; C:nuclear periphery; IEA:UniProtKB-ARBA.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-ARBA.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR FunFam; 1.10.287.1490:FF:000004; nucleoprotein TPR isoform X2; 1.
DR FunFam; 1.10.287.1490:FF:000005; nucleoprotein TPR isoform X2; 1.
DR Gene3D; 1.10.287.1490; -; 2.
DR InterPro; IPR012929; TPR/MLP1.
DR PANTHER; PTHR18898:SF2; NUCLEOPROTEIN TPR; 1.
DR PANTHER; PTHR18898; NUCLEOPROTEIN TPR-RELATED; 1.
DR Pfam; PF25481; Nucleoprot-TPR; 1.
DR Pfam; PF07926; TPR_MLP1_2; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW mRNA transport {ECO:0000256|ARBA:ARBA00022816};
KW Nuclear pore complex {ECO:0000256|ARBA:ARBA00023132};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Translocation {ECO:0000256|ARBA:ARBA00023010};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 1039..1166
FT /note="Nucleoprotein TPR/MLP1"
FT /evidence="ECO:0000259|Pfam:PF07926"
FT REGION 913..936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1452..1472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1619..1674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1804..2331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 29..172
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 219..281
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 321..366
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 427..513
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 543..603
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 665..801
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1221..1416
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 913..929
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1458..1472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1619..1631
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1633..1652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1804..1828
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1867..1881
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1884..1893
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1924..1936
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1947..1989
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1999..2020
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2028..2065
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2173..2212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2213..2226
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2227..2240
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2241..2251
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2253..2267
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2268..2288
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2320..2331
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2331 AA; 264157 MW; AE9CEB01AA5BD8A2 CRC64;
MAAVLQQVLE RAELNKLPKS VQNKLEKFLA DQQSEIDGLK GRHEKFKVES EQQYFEIEKR
LSHSQERLVN ETRECQNLRL ELEKLNNQLK ALTEKNKELE VAQDRNIAIQ SQFTRTKEEL
EAEKRDLIRT NERLSQELEY LTEDVKRLNE KLKESNATKG DLQLKLDELQ ASDVSVKYRE
KRLEQEKELL HNQNTWLNTE LKTKTDELLA LGREKGNEIL ELKCNLENKK EEVSRMEEQM
NGLKTSNENL QKHVEDLLTK LKEAKEQQAS MEEKFHNELN AHIKLSNLYK SAADDSEAKS
NELTRAVDEL HKLLKEAGEA NKAIQDHLLE VEKSKEQMEK EMLEKIGKLE KELENANDLL
SATKRKGAIL SEEELAAMSP TAAAVAKIVK PGMKLTELYN AYVETQDQLL LEKLENKRIN
KYLDEIVKEV EAKAPILKRQ REEYERAQKA VASLSVKLEQ AMKEIQRLQE DTDKANKHSS
VLERDNQRME IQIKDLSQQI RVLLMELEEA RGNHVIRDEE VSSADISSSS EVISQHLVSY
RNIEELQQQN QRLLVALREL GETREREEQE TTSSKITELQ LKLENALTEL EQLRESRQHQ
MQLVDSIVRQ RDMYRILLSQ ITGVNIPLQA SSLDDISLVS TPKRSSTSQT VSTPAPVPVI
ESAEAIEAKA ALKQLQEIFE NYKKEKADNE KIQNEQLEKF QEQVTDLRSQ NTKISTQLDF
ASKRYEMLQD NVEGYRREIT SLHERNQKLT ATTQKQEQII NTMTQDLRGA SEKLAVAEVR
ADNLKKEKEM LKLSEVRLSQ QRESLLAEQR GQNLLLTNLQ TIQGILERSE TETKQRLSNQ
IEKLENEISH LKKKLENEVE QRHTLTRNLD VQLLDTKRQL DTETNLHLNT KELLKNAQKE
IATLKQHLSN MEVQLASQSS QRSGKGQPNS KEDVDDLLSQ LRQTEEQVND LKERLKTSTS
NVEQYRAMVT SLEESLNKEK QVTEEVRKNI EVRLKESAEF QTQLEKKLME VEKEKQELQD
DKRKAIESME QQLSELKKTL TNVQNEVQEA LQRASTALSN EQQARRDCQE QAKIAVEAQN
KYERELMLHA ADVEALQAAK EQVSKMASVR QHLEETTQKA ESQLLECKAS WEERERMLKD
EVSKCVSRCE DLEKQNRLLH DQIEKLSDKV VASMKEGVQG PLNISLSEEG KSQEQILEIL
RFIRREKEIA ETRFEVAQVE SLRYRQRVEL LERELQELQD SLNVEREKVQ VTAKTMAQHE
ELMKKTETMN VVMETNKMLR EEKERLEQDL QQMQAKVRKL ELDILPLQEA NAELSEKSGM
LQAEKKLLEE DVKRWKARNQ HLVSQQKDPD TEEYRKLLSE KEVHTKRIQQ LTEEIGRLKA
EIARSNASLT NNQNLIQSLK EDLNKVRTEK ESIQKDLDAK IIDIQEKVKT ITQVKKIGRR
YKTQYEELKA QQDKAMETSA QSSGDHQEQH VSVQEMQELK ETLNQAETKS KSLENQVENL
QKTLSEKETE ARNLQEQTVQ LQSELSRLRQ DLQDRTTQEE QLRQQITEKE EKTRKAIVAA
KSKIAHLAGV KDQLTKENEE LKQRNGALDQ QKDELDVRMT ALKSQYEGRI SRLERELREH
QERHLEQRDE PQEPTNKVPE QQRQITLKTT PASGERGIAS TSDPPTANIK PTPVVSTPSK
VTAAAMAGNK STPRASIRPM VTPATVTNPT TTPTATVMPT TQVESQEAMQ SEGPVEHVPV
FGSTSGSVRS TSPNVQPSIP QPILTVQQQT QATAFVQPTQ QSHPQIEPAN QELSPNIVEV
VQSSPVERPS TSTAVFGTVS ATPSSSLPKR TREEEEDSTI EASDQVSDDT VEMPLPKKLK
SVTPVGTEEE VMAEESTDGE VETQVYNQDS QDSIGEGVTQ GDYTPMEDSE ETSQSLQIDL
GPLQSDQQTT TSSQDGQGKG DDVIVIDSDD EEDDDDDNDG EHEDYEEDEE EDDDDEDDTG
MGDEGEDSNE GTGSADGNDG YEADDAEGGD GTDPGTETEE SMGGGESNQR AADSQNSGEG
NTGTAESSFS QEIAREQQPS SASERQTPRA PQSPRRPPHP LPPRLTIHAP PQELGPPVQR
IQMTRRQSVG RGLQLTPGIG GMQQHFFDDE DRTVPSTPTL VVPHRTDGFA EAIHSPQVAG
VPRFRFGPPE DMPQTSSSHS DLGQLASQGV TVFTESTTSD ASEHASQSVP MVTTSTGTLS
TTNETATGDD GDEVFVEAES EGISSEAGLE IDSQQEEEPV QASDESDLPS TSQDPPSSSS
VDTSSSQPKP FRRVRLQTTL RQGVRGRQFN RQRGVSHAMG GRGGINRGNI N
//
