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Database: UniProt
Entry: A0A9L0TI43_HORSE
LinkDB: A0A9L0TI43_HORSE
Original site: A0A9L0TI43_HORSE 
ID   A0A9L0TI43_HORSE        Unreviewed;       481 AA.
AC   A0A9L0TI43;
DT   13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 1.
DT   18-JUN-2025, entry version 11.
DE   SubName: Full=Solute carrier family 28 member 1 {ECO:0000313|Ensembl:ENSECAP00000086813.1};
GN   Name=SLC28A1 {ECO:0000313|VGNC:VGNC:23135};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000086813.1, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000086813.1, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000086813.1,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000086813.1}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000086813.1};
RG   Ensembl;
RL   Submitted (MAR-2025) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC   -!- SIMILARITY: Belongs to the concentrative nucleoside transporter (CNT)
CC       (TC 2.A.41) family. {ECO:0000256|ARBA:ARBA00009033}.
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DR   Ensembl; ENSECAT00000116613.1; ENSECAP00000086813.1; ENSECAG00000007499.4.
DR   VGNC; VGNC:23135; SLC28A1.
DR   GeneTree; ENSGT00390000016025; -.
DR   Proteomes; UP000002281; Chromosome 1.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR008276; C_nuclsd_transpt.
DR   InterPro; IPR011657; CNT_C_dom.
DR   InterPro; IPR002668; CNT_N_dom.
DR   InterPro; IPR011642; Gate_dom.
DR   PANTHER; PTHR10590; SODIUM/NUCLEOSIDE COTRANSPORTER; 1.
DR   PANTHER; PTHR10590:SF16; SODIUM_NUCLEOSIDE COTRANSPORTER 1; 1.
DR   Pfam; PF07670; Gate; 1.
DR   Pfam; PF07662; Nucleos_tra2_C; 1.
DR   Pfam; PF01773; Nucleos_tra2_N; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        79..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        108..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        146..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        174..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        200..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        260..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        338..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        364..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        400..424
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          181..253
FT                   /note="Concentrative nucleoside transporter N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01773"
FT   DOMAIN          261..359
FT                   /note="Nucleoside transporter/FeoB GTPase Gate"
FT                   /evidence="ECO:0000259|Pfam:PF07670"
FT   DOMAIN          355..420
FT                   /note="Concentrative nucleoside transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF07662"
SQ   SEQUENCE   481 AA;  53115 MW;  C759D20C80FD5555 CRC64;
     MEDNASRRRE SISLRSMANG LENAGAEFLE NLEEGWTPGS DWSPAVDGRS EAGPEPSAGW
     RILQPALGVR RFCREHVRLW RWICIGLLCT AFAAFLLIAC LLDFQRALAL FVLTCVVLVF
     LAHSLLKRLL GPKLWRRVEP LGHSRLNLWL KRGLALAAFL GLVLWLALDT SRRPEQLVSF
     AGICVFIGLL FACSKHHRAV SWRAVSWGLG LQFILGLFVI RTEPGFTAFQ WLGDQIQIFL
     RYTEAGSSFV FGDTLVKDVF AFQVLPIIVF FSCIMSVLYY VGLMQWVILK IAWLMQVTMG
     TTATETLSVA GNIFVSQTEA PLLIRPYLAD MTLSEIHVVM TGGYATIAGS LLGAYISFGV
     RAEILTTFAL CGFANFSSIG IMLGGLTSMV PQRKSDFSQI VLRALCTGAC VSLVNACVAG
     ILYVPRGAEV NCTALLNTIL SSSSFEVYQC CREAFQSTSP EFSPEALDNC CRFYNHTTCA
     R
//
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